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The Journal of Immunology, 2004, 172: 4245-4252.
Copyright © 2004 by The American Association of Immunologists

IFN-{gamma} Stimulates the Expression of a Novel Secretoglobin That Regulates Chemotactic Cell Migration and Invasion

Moonsuk S. Choi, Rabindranath Ray, Zhongjian Zhang and Anil B. Mukherjee1

Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892

IFNs are a family of cytokines that alert the immune system against viral infections of host cells. The IFNs (IFN-{alpha}, IFN-{beta}, and IFN-{gamma}) interact with specific cellular receptors and stimulate the production of second messengers, leading to the expression of antiviral and immunomodulatory proteins. We report in this study that IFN-{gamma} stimulates the expression of a novel gene that encodes a protein with 30% amino acid sequence identity with uteroglobin, the founding member of the newly formed Secretoglobin (SCGB) superfamily. We named this protein IFN-{gamma}-inducible SCGB (IIS), because its expression in lymphoblast cells is augmented by IFN-{gamma} treatment. IIS is expressed in virtually all tissues, and the highest level of expression is detectable in lymph nodes, tonsil, cultured lymphoblasts, and the ovary. Interestingly, although the expression of IIS mRNA is not significantly different in resting lymphoid cells, it is markedly elevated in activated CD8+ and CD19+ cells. Furthermore, treatment of lymphoblast cells with IIS antisense phosphorothioate (S)-oligonucleotides prevents chemotactic migration and invasion. Taken together, these results raise the possibility that this novel SCGB has immunological functions.


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The JI 2004 172: 3981-3982. [Full Text]  





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