| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Dermatology, University of Leipzig, Leipzig, Germany;
Department of Medicine I, University of Heidelberg, Heidelberg, Germany;
Institute for Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany; and
Saxon Academy of Science, Leipzig, Germany
Leukocyte recruitment in response to inflammatory signals is in part governed by interactions between endothelial cell receptors belonging to the Ig superfamily and leukocyte integrins. In our previous work, the human Ig superfamily glycoprotein Thy-1 (CD90) was identified as an activation-associated cell adhesion molecule on human dermal microvascular endothelial cells. Furthermore, the interaction of Thy-1 with a corresponding ligand on monocytes and polymorphonuclear cells was shown to be involved in the adhesion of these leukocytes to activated Thy-1-expressing endothelial cells. In this study, we have identified the specific interaction between human Thy-1 and the leukocyte integrin Mac-1 (CD11b/CD18; 
M
2) both in cellular systems and in purified form. Monocytes and polymorphonuclear cells were shown to adhere to transfectants expressing human Thy-1 as well as to primary Thy-1-expressing human dermal microvascular endothelial cells. Furthermore, leukocyte adhesion to activated endothelium as well as the subsequent transendothelial migration was mediated by the interaction between Thy-1 and Mac-1. This additional pathway in leukocyte-endothelium interaction may play an important role in the regulation of leukocyte recruitment to sites of inflammation.
This article has been cited by other articles:
|
|
 |
|
  Y. Zhou, K. Koli, J. S. Hagood, M. Miao, M. Mavalli, D. B. Rifkin, and J. E. Murphy-Ullrich Latent Transforming Growth Factor-{beta}-Binding Protein-4 Regulates Transforming Growth Factor-{beta}1 Bioavailability for Activation by Fibrogenic Lung Fibroblasts in Response to Bleomycin Am. J. Pathol., January 1, 2009; 174(1): 21 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Saalbach, C. Klein, J. Sleeman, U. Sack, F. Kauer, C. Gebhardt, M. Averbeck, U. Anderegg, and J. C. Simon Dermal Fibroblasts Induce Maturation of Dendritic Cells J. Immunol., April 15, 2007; 178(8): 4966 - 4974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zirlik, C. Maier, N. Gerdes, L. MacFarlane, J. Soosairajah, U. Bavendiek, I. Ahrens, S. Ernst, N. Bassler, A. Missiou, et al. CD40 Ligand Mediates Inflammation Independently of CD40 by Interaction With Mac-1 Circulation, March 27, 2007; 115(12): 1571 - 1580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Rege and J. S. Hagood Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis FASEB J, June 1, 2006; 20(8): 1045 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tzima Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Shear Stress Response Circ. Res., February 3, 2006; 98(2): 176 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. M. Haeryfar and D. W. Hoskin Thy-1: More than a Mouse Pan-T Cell Marker J. Immunol., September 15, 2004; 173(6): 3581 - 3588. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
