| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Tokyo, Japan;
Second Department of Internal Medicine, Nara Medical University, Nara, Japan; and
Department of Anatomy and Developmental Biology, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan
We previously reported that B lymphocyte chemoattractant (BLC; CXCL13) was highly and ectopically expressed in aged (NZB x NZW)F1 (BWF1) mice developing lupus nephritis, and that B1 cells were preferentially chemoattracted toward BLC. We demonstrate in this study that B1 cells fail to home to the peritoneal cavity in aged BWF1 mice developing lupus nephritis, and that they are preferentially recruited to the target organs including the kidney, lung, and thymus when injected i.v. In contrast, B1 cells homed to the peritoneal cavity in aged BALB/c mice as effectively as in young mice. Accumulation of B1 cells to the omentum milky spots was also impaired in aged BWF1 mice compared with young mice. CD11bhighF4/80high cells with macrophage morphology were confirmed to be a major cell source for BLC in the peritoneal cavity both in young and aged BWF1 mice. However, the number of BLC-producing peritoneal macrophages was markedly decreased in aged BWF1 mice. These results suggest that the decreased number of BLC-producing peritoneal macrophages together with ectopic high expression of BLC in aged BWF1 mice result in abnormal B1 cell trafficking during the development of murine lupus.
This article has been cited by other articles:
|
|
 |
|
  A. L. Fletcher, N. Seach, J. J. Reiseger, T. E. Lowen, M. V. Hammett, H. S. Scott, and R. L. Boyd Reduced Thymic Aire Expression and Abnormal NF-{kappa}B2 Signaling in a Model of Systemic Autoimmunity J. Immunol., March 1, 2009; 182(5): 2690 - 2699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lee, W. Chen, K. Su, C. Chou, and C. Tsai Myasthenia gravis associated with lupus nephritis Lupus, September 1, 2008; 17(9): 860 - 861. [PDF]
|
|
|
|
|
|
S. Berberich, S. Dahne, A. Schippers, T. Peters, W. Muller, E. Kremmer, R. Forster, and O. Pabst Differential Molecular and Anatomical Basis for B Cell Migration into the Peritoneal Cavity and Omental Milky Spots J. Immunol., February 15, 2008; 180(4): 2196 - 2203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Burkle, M. Niedermeier, A. Schmitt-Graff, W. G. Wierda, M. J. Keating, and J. A. Burger Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia Blood, November 1, 2007; 110(9): 3316 - 3325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Smith-Berdan, D. Gille, I. L. Weissman, and J. L. Christensen Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells Blood, August 15, 2007; 110(4): 1370 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Berberich, R. Forster, and O. Pabst The peritoneal micromilieu commits B cells to home to body cavities and the small intestine Blood, June 1, 2007; 109(11): 4627 - 4634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. V. Bagaeva, P. Rao, J. M. Powers, and B. M. Segal CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis. J. Immunol., June 15, 2006; 176(12): 7676 - 7685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O. Orlova, K. B. Majorov, I. V. Lyadova, E. B. Eruslanov, C. E. M'lan, C. M. T. Greenwood, E. Schurr, and A. S. Apt Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice. Infect. Immun., June 1, 2006; 74(6): 3668 - 3672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xu, B. Duan, B. P. Croker, E. K. Wakeland, and L. Morel Genetic Dissection of the Murine Lupus Susceptibility Locus Sle2: Contributions to Increased Peritoneal B-1a Cells and Lupus Nephritis Map to Different Loci J. Immunol., July 15, 2005; 175(2): 936 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Akadegawa, S. Ishikawa, T. Sato, J. Suzuki, H. Yurino, M. Kitabatake, T. Ito, T. Kuriyama, and K. Matsushima Breakdown of Mucosal Immunity in the Gut and Resultant Systemic Sensitization by Oral Antigens in a Murine Model for Systemic Lupus Erythematosus J. Immunol., May 1, 2005; 174(9): 5499 - 5506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Stuart, K. Takahashi, L. Shi, J. Savill, and R. A. B. Ezekowitz Mannose-Binding Lectin-Deficient Mice Display Defective Apoptotic Cell Clearance but No Autoimmune Phenotype J. Immunol., March 15, 2005; 174(6): 3220 - 3226. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
