The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jameson, J. M.
Right arrow Articles by Havran, W. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jameson, J. M.
Right arrow Articles by Havran, W. L.
The Journal of Immunology, 2004, 172: 3573-3579.
Copyright © 2004 by The American Association of Immunologists

A Keratinocyte-Responsive {gamma}{delta} TCR Is Necessary for Dendritic Epidermal T Cell Activation by Damaged Keratinocytes and Maintenance in the Epidermis1

Julie M. Jameson, Gabrielle Cauvi, Deborah A. Witherden and Wendy L. Havran2

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037

A unique population of T lymphocytes, designated dendritic epidermal T cells (DETC), homes to the murine epidermis during fetal development. DETC express a canonical {gamma}{delta} TCR, V{gamma}3/V{delta}1, which recognizes Ag expressed on damaged, stressed, or transformed keratinocytes. Recently, DETC were shown to play a key role in the complex process of wound repair. To examine the role of the DETC TCR in DETC localization to the epidermis, maintenance in the skin, and activation in vivo, we analyzed DETC in the TCR{delta}-/- mouse. Unlike previous reports in which the TCR{delta}-/- skin was found to be devoid of any DETC, we discovered that TCR{delta}-/- mice have {alpha}{beta} TCR-expressing DETC with a polyclonal V{beta} chain repertoire. The {alpha}{beta} DETC are not retained over the life of the animal, suggesting that the {gamma}{delta} TCR is critical for the maintenance of DETC in the skin. Although the {alpha}{beta} DETC can be activated in response to direct stimulation, they do not respond to keratinocyte damage. Our results suggest that a keratinocyte-responsive TCR is necessary for DETC activation in response to keratinocyte damage and for DETC maintenance in the epidermis.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
R. E. Mills, K. R. Taylor, K. Podshivalova, D. B. McKay, and J. M. Jameson
Defects in Skin {gamma}{delta} T Cell Function Contribute to Delayed Wound Repair in Rapamycin-Treated Mice
J. Immunol., September 15, 2008; 181(6): 3974 - 3983.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Z. Li, A. R. Burns, R. E. Rumbaut, and C. W. Smith
{gamma}{delta} T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion
Am. J. Pathol., September 1, 2007; 171(3): 838 - 845.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. M. Wands, C. L. Roark, M. K. Aydintug, N. Jin, Y.-S. Hahn, L. Cook, X. Yin, J. Dal Porto, M. Lahn, D. M. Hyde, et al.
Distribution and leukocyte contacts of {gamma}{delta} T cells in the lung
J. Leukoc. Biol., November 1, 2005; 78(5): 1086 - 1096.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.