The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Skerrett, S. J.
Right arrow Articles by Wilson, C. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Skerrett, S. J.
Right arrow Articles by Wilson, C. B.
The Journal of Immunology, 2004, 172: 3377-3381.
Copyright © 2004 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Myeloid Differentiation Factor 88 Is Essential for Pulmonary Host Defense against Pseudomonas aeruginosa but Not Staphylococcus aureus1

Shawn J. Skerrett2,*, H. Denny Liggitt{dagger}, Adeline M. Hajjar{ddagger} and Christopher B. Wilson{ddagger}

Departments of * Medicine, {dagger} Comparative Medicine, and {ddagger} Immunology, University of Washington, School of Medicine, Seattle, WA 98195

Myeloid differentiation factor 88 (MyD88) is an adapter molecule required for signal transduction via Toll-like receptors (TLRs) and receptors of the IL-1 family. Consequently, MyD88-deficient mice are highly susceptible to bacterial infections, including systemic infection with Staphylococcus aureus. To determine the role of MyD88 in innate immunity to bacterial pneumonia, we exposed MyD88-deficient and wild-type mice to aerosolized Pseudomonas aeruginosa or S. aureus. As predicted, MyD88-deficient mice failed to mount an early cytokine or inflammatory response or to control bacterial replication after infection with P. aeruginosa, which resulted in necrotizing pneumonia and death. By contrast, MyD88-deficient mice controlled S. aureus infection despite blunted local cytokine and inflammatory responses. Thus, whereas MyD88-dependent signaling is integral to the initiation of cytokine and inflammatory responses to both pathogens following infection of the lower respiratory tract, MyD88 is essential for innate immunity to P. aeruginosa but not S. aureus.




This article has been cited by other articles:


Home page
 Infect. Immun.Home page
A. Craig, J. Mai, S. Cai, and S. Jeyaseelan
Neutrophil Recruitment to the Lungs during Bacterial Pneumonia
Infect. Immun., February 1, 2009; 77(2): 568 - 575.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. L. Ventura, R. Higdon, L. Hohmann, D. Martin, E. Kolker, H. D. Liggitt, S. J. Skerrett, and C. E. Rubens
Staphylococcus aureus Elicits Marked Alterations in the Airway Proteome during Early Pneumonia
Infect. Immun., December 1, 2008; 76(12): 5862 - 5872.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Koller, M. Kappler, P. Latzin, A. Gaggar, M. Schreiner, S. Takyar, M. Kormann, M. Kabesch, D. Roos, M. Griese, et al.
TLR Expression on Neutrophils at the Pulmonary Site of Infection: TLR1/TLR2-Mediated Up-Regulation of TLR5 Expression in Cystic Fibrosis Lung Disease
J. Immunol., August 15, 2008; 181(4): 2753 - 2763.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. von Bernuth, C. Picard, Z. Jin, R. Pankla, H. Xiao, C.-L. Ku, M. Chrabieh, I. B. Mustapha, P. Ghandil, Y. Camcioglu, et al.
Pyogenic Bacterial Infections in Humans with MyD88 Deficiency
Science, August 1, 2008; 321(5889): 691 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. R. Martin
Interactions between Mechanical and Biological Processes in Acute Lung Injury
Proceedings of the ATS, April 15, 2008; 5(3): 291 - 296.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Leendertse, R. J. L. Willems, I. A. J. Giebelen, P. S. van den Pangaart, W. J. Wiersinga, A. F. de Vos, S. Florquin, M. J. M. Bonten, and T. van der Poll
TLR2-Dependent MyD88 Signaling Contributes to Early Host Defense in Murine Enterococcus faecium Peritonitis
J. Immunol., April 1, 2008; 180(7): 4865 - 4874.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. L. Ventura, R. Higdon, E. Kolker, S. J. Skerrett, and C. E. Rubens
Host Airway Proteins Interact with Staphylococcus aureus during Early Pneumonia
Infect. Immun., March 1, 2008; 76(3): 888 - 898.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. P. Mizgerd
Acute Lower Respiratory Tract Infection
N. Engl. J. Med., February 14, 2008; 358(7): 716 - 727.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
T. R. Hawn, W. R. Berrington, I. A. Smith, S. Uematsu, S. Akira, A. Aderem, K. D. Smith, and S. J. Skerrett
Altered Inflammatory Responses in TLR5-Deficient Mice Infected with Legionella pneumophila
J. Immunol., November 15, 2007; 179(10): 6981 - 6987.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C.-L. Ku, H. von Bernuth, C. Picard, S.-Y. Zhang, H.-H. Chang, K. Yang, M. Chrabieh, A. C. Issekutz, C. K. Cunningham, J. Gallin, et al.
Selective predisposition to bacterial infections in IRAK-4 deficient children: IRAK-4 dependent TLRs are otherwise redundant in protective immunity
J. Exp. Med., October 1, 2007; 204(10): 2407 - 2422.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. Bhan, N. W. Lukacs, J. J. Osterholzer, M. W. Newstead, X. Zeng, T. A. Moore, T. R. McMillan, A. M. Krieg, S. Akira, and T. J. Standiford
TLR9 Is Required for Protective Innate Immunity in Gram-Negative Bacterial Pneumonia: Role of Dendritic Cells
J. Immunol., September 15, 2007; 179(6): 3937 - 3946.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Reiniger, M. M. Lee, F. T. Coleman, C. Ray, D. E. Golan, and G. B. Pier
Resistance to Pseudomonas aeruginosa Chronic Lung Infection Requires Cystic Fibrosis Transmembrane Conductance Regulator-Modulated Interleukin-1 (IL-1) Release and Signaling through the IL-1 Receptor
Infect. Immun., April 1, 2007; 75(4): 1598 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Jeyaseelan, S. K. Young, M. B. Fessler, Y. Liu, K. C. Malcolm, M. Yamamoto, S. Akira, and G. S. Worthen
Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-beta (TRIF)-Mediated Signaling Contributes to Innate Immune Responses in the Lung during Escherichia coli Pneumonia
J. Immunol., March 1, 2007; 178(5): 3153 - 3160.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. R. Power, B. Li, M. Yamamoto, S. Akira, and T.-J. Lin
A Role of Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-beta in the Host Response to Pseudomonas aeruginosa Lung Infection in Mice
J. Immunol., March 1, 2007; 178(5): 3170 - 3176.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Kapetanovic, M.-A. Nahori, V. Balloy, C. Fitting, D. J. Philpott, J.-M. Cavaillon, and M. Adib-Conquy
Contribution of Phagocytosis and Intracellular Sensing for Cytokine Production by Staphylococcus aureus-Activated Macrophages
Infect. Immun., February 1, 2007; 75(2): 830 - 837.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. J. Skerrett, C. B. Wilson, H. D. Liggitt, and A. M. Hajjar
Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa
Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L312 - L322.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. M. Hajjar, M. D. Harvey, S. A. Shaffer, D. R. Goodlett, A. Sjostedt, H. Edebro, M. Forsman, M. Bystrom, M. Pelletier, C. B. Wilson, et al.
Lack of In Vitro and In Vivo Recognition of Francisella tularensis Subspecies Lipopolysaccharide by Toll-Like Receptors
Infect. Immun., December 1, 2006; 74(12): 6730 - 6738.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Jeyaseelan, S. K. Young, M. Yamamoto, P. G. Arndt, S. Akira, J. K. Kolls, and G. S. Worthen
Toll/IL-1R Domain-Containing Adaptor Protein (TIRAP) Is a Critical Mediator of Antibacterial Defense in the Lung against Klebsiella pneumoniae but Not Pseudomonas aeruginosa
J. Immunol., July 1, 2006; 177(1): 538 - 547.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. A. Delgado, J. F. Poschet, and V. Deretic
Nonclassical Pathway of Pseudomonas aeruginosa DNA-Induced Interleukin-8 Secretion in Cystic Fibrosis Airway Epithelial Cells.
Infect. Immun., May 1, 2006; 74(5): 2975 - 2984.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. T. Sadikot, H. Zeng, M. Joo, M. B. Everhart, T. P. Sherrill, B. Li, D.-s. Cheng, F. E. Yull, J. W. Christman, and T. S. Blackwell
Targeted Immunomodulation of the NF-{kappa}B Pathway in Airway Epithelium Impacts Host Defense against Pseudomonas aeruginosa.
J. Immunol., April 15, 2006; 176(8): 4923 - 4930.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. M. van der Sar, O. W. Stockhammer, C. van der Laan, H. P. Spaink, W. Bitter, and A. H. Meijer
MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model
Infect. Immun., April 1, 2006; 74(4): 2436 - 2441.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. K. Behera, E. Hildebrand, R. T. Bronson, G. Perides, S. Uematsu, S. Akira, and L. T. Hu
MyD88 Deficiency Results in Tissue-Specific Changes in Cytokine Induction and Inflammation in Interleukin-18-Independent Mice Infected with Borrelia burgdorferi
Infect. Immun., March 1, 2006; 74(3): 1462 - 1470.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Knapp, C. W. Wieland, S. Florquin, R. Pantophlet, L. Dijkshoorn, N. Tshimbalanga, S. Akira, and T. van der Poll
Differential Roles of CD14 and Toll-like Receptors 4and 2 in Murine Acinetobacter Pneumonia
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 122 - 129.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. R. Martin and C. W. Frevert
Innate Immunity in the Lungs
Proceedings of the ATS, December 1, 2005; 2(5): 403 - 411.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Jeyaseelan, R. Manzer, S. K. Young, M. Yamamoto, S. Akira, R. J. Mason, and G. S. Worthen
Toll-IL-1 Receptor Domain-Containing Adaptor Protein Is Critical for Early Lung Immune Responses against Escherichia coli Lipopolysaccharide and Viable Escherichia coli
J. Immunol., December 1, 2005; 175(11): 7484 - 7495.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y. Sang, B. Ramanathan, C. R. Ross, and F. Blecha
Gene Silencing and Overexpression of Porcine Peptidoglycan Recognition Protein Long Isoforms: Involvement in {beta}-Defensin-1 Expression
Infect. Immun., November 1, 2005; 73(11): 7133 - 7141.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. M. Hajjar, H. Harowicz, H. D. Liggitt, P. J. Fink, C. B. Wilson, and S. J. Skerrett
An Essential Role for Non-Bone Marrow-Derived Cells in Control of Pseudomonas aeruginosa Pneumonia
Am. J. Respir. Cell Mol. Biol., November 1, 2005; 33(5): 470 - 475.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. W. Wieland, S. Florquin, N. A. Maris, K. Hoebe, B. Beutler, K. Takeda, S. Akira, and T. van der Poll
The MyD88-Dependent, but Not the MyD88-Independent, Pathway of TLR4 Signaling Is Important in Clearing Nontypeable Haemophilus influenzae from the Mouse Lung
J. Immunol., November 1, 2005; 175(9): 6042 - 6049.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Ramphal, V. Balloy, M. Huerre, M. Si-Tahar, and M. Chignard
TLRs 2 and 4 Are Not Involved in Hypersusceptibility to Acute Pseudomonas aeruginosa Lung Infections
J. Immunol., September 15, 2005; 175(6): 3927 - 3934.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Naiki, K. S. Michelsen, N. W. J. Schroder, R. Alsabeh, A. Slepenkin, W. Zhang, S. Chen, B. Wei, Y. Bulut, M. H. Wong, et al.
MyD88 Is Pivotal for the Early Inflammatory Response and Subsequent Bacterial Clearance and Survival in a Mouse Model of Chlamydia pneumoniae Pneumonia
J. Biol. Chem., August 12, 2005; 280(32): 29242 - 29249.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
B. Fournier and D. J. Philpott
Recognition of Staphylococcus aureus by the Innate Immune System
Clin. Microbiol. Rev., July 1, 2005; 18(3): 521 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Yang, F. M. Murillo, M. J. Delannoy, R. L. Blosser, W. H. Yutzy IV, S. Uematsu, K. Takeda, S. Akira, R. P. Viscidi, and R. B. S. Roden
B Lymphocyte Activation by Human Papillomavirus-Like Particles Directly Induces Ig Class Switch Recombination via TLR4-MyD88
J. Immunol., June 15, 2005; 174(12): 7912 - 7919.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. T. Sadikot, T. S. Blackwell, J. W. Christman, and A. S. Prince
Pathogen-Host Interactions in Pseudomonas aeruginosa Pneumonia
Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1209 - 1223.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
H. Bjorkbacka, K. A. Fitzgerald, F. Huet, X. Li, J. A. Gregory, M. A. Lee, C. M. Ordija, N. E. Dowley, D. T. Golenbock, and M. W. Freeman
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades
Physiol Genomics, February 7, 2005; 19(3): 319 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. R. Schurr, E. Young, P. Byrne, C. Steele, J. E. Shellito, and J. K. Kolls
Central Role of Toll-Like Receptor 4 Signaling and Host Defense in Experimental Pneumonia Caused by Gram-Negative Bacteria
Infect. Immun., January 1, 2005; 73(1): 532 - 545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. R. Power, Y. Peng, E. Maydanski, J. S. Marshall, and T.-J. Lin
The Development of Early Host Response to Pseudomonas aeruginosa Lung Infection Is Critically Dependent on Myeloid Differentiation Factor 88 in Mice
J. Biol. Chem., November 19, 2004; 279(47): 49315 - 49322.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Kumar, J. Zhang, and F.-S. X. Yu
Innate Immune Response of Corneal Epithelial Cells to Staphylococcus aureus Infection: Role of Peptidoglycan in Stimulating Proinflammatory Cytokine Secretion
Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3513 - 3522.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. E. Yauch, M. K. Mansour, S. Shoham, J. B. Rottman, and S. M. Levitz
Involvement of CD14, Toll-Like Receptors 2 and 4, and MyD88 in the Host Response to the Fungal Pathogen Cryptococcus neoformans In Vivo
Infect. Immun., September 1, 2004; 72(9): 5373 - 5382.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.