The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Manser, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Manser, T.
The Journal of Immunology, 2004, 172: 3369-3375.
Copyright © 2004 by The American Association of Immunologists

BRIEF REVIEWS

Textbook Germinal Centers?1

Tim Manser2

Kimmel Cancer Center and Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107

Models for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny. Indeed, recent studies have called several of their principal assumptions into question. In addition, the term germinal center has been applied to a diverse assortment of focal processes of B cell proliferation and differentiation. This variability might be explained by alterations in the progression of a single textbook GC process. Alternatively, distinct developmental pathways may create unique classes of GCs with specialized functions.




This article has been cited by other articles:


Home page
 J Mol Cell BiolHome page
E. Bi and B. H. Ye
An Expanding Job Description for Bcl6
J Mol Cell Biol, September 30, 2009; (2009) mjp032v1.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S.-i. Honda, N. Kurita, A. Miyamoto, Y. Cho, K. Usui, K. Takeshita, S. Takahashi, T. Yasui, H. Kikutani, T. Kinoshita, et al.
Enhanced humoral immune responses against T-independent antigens in Fc{alpha}/{micro}R-deficient mice
PNAS, July 7, 2009; 106(27): 11230 - 11235.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. H. Achtman, U. E. Hopken, C. Bernert, and M. Lipp
CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens
J. Leukoc. Biol., March 1, 2009; 85(3): 409 - 417.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. T. Figge, A. Garin, M. Gunzer, M. Kosco-Vilbois, K.-M. Toellner, and M. Meyer-Hermann
Deriving a germinal center lymphocyte migration model from two-photon data
J. Exp. Med., December 22, 2008; 205(13): 3019 - 3029.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Murray, N. Darzentas, A. Hadzidimitriou, G. Tobin, M. Boudjogra, C. Scielzo, N. Laoutaris, K. Karlsson, F. Baran-Marzsak, A. Tsaftaris, et al.
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
Blood, February 1, 2008; 111(3): 1524 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Bombardieri, F. Barone, F. Humby, S. Kelly, M. McGurk, P. Morgan, S. Challacombe, S. De Vita, G. Valesini, J. Spencer, et al.
Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjogren's Syndrome
J. Immunol., October 1, 2007; 179(7): 4929 - 4938.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Al-Alwan, Q. Du, S. Hou, B. Nashed, Y. Fan, X. Yang, and A. J. Marshall
Follicular Dendritic Cell Secreted Protein (FDC-SP) Regulates Germinal Center and Antibody Responses
J. Immunol., June 15, 2007; 178(12): 7859 - 7867.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. I. Kuraishy, S. W. French, M. Sherman, M. Herling, D. Jones, R. Wall, and M. A. Teitell
TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation
PNAS, June 12, 2007; 104(24): 10175 - 10180.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. J. Maglione, J. Xu, and J. Chan
B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis
J. Immunol., June 1, 2007; 178(11): 7222 - 7234.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. M. Radcliffe, J. N. Arnold, D. M. Suter, M. R. Wormald, D. J. Harvey, L. Royle, Y. Mimura, Y. Kimura, R. B. Sim, S. Inoges, et al.
Human Follicular Lymphoma Cells Contain Oligomannose Glycans in the Antigen-binding Site of the B-cell Receptor
J. Biol. Chem., March 9, 2007; 282(10): 7405 - 7415.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. D. C. Allen, T. Okada, H. L. Tang, and J. G. Cyster
Imaging of Germinal Center Selection Events During Affinity Maturation
Science, January 26, 2007; 315(5811): 528 - 531.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-M. Hogerkorp and C. A. K. Borrebaeck
The Human CD77- B Cell Population Represents a Heterogeneous Subset of Cells Comprising Centroblasts, Centrocytes, and Plasmablasts, Prompting Phenotypical Revision
J. Immunol., October 1, 2006; 177(7): 4341 - 4349.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. F. Fecteau, G. Cote, and S. Neron
A New Memory CD27-IgG+ B Cell Population in Peripheral Blood Expressing VH Genes with Low Frequency of Somatic Mutation
J. Immunol., September 15, 2006; 177(6): 3728 - 3736.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Larousserie, P. Charlot, E. Bardel, J. Froger, R. A. Kastelein, and O. Devergne
Differential Effects of IL-27 on Human B Cell Subsets
J. Immunol., May 15, 2006; 176(10): 5890 - 5897.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
K. J. Tinckam and A. Chandraker
Mechanisms and Role of HLA and non-HLA Alloantibodies
Clin. J. Am. Soc. Nephrol., May 1, 2006; 1(3): 404 - 414.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Yang, G. C. Waldbieser, and C. J. Lobb
The Nucleotide Targets of Somatic Mutation and the Role of Selection in Immunoglobulin Heavy Chains of a Teleost Fish
J. Immunol., February 1, 2006; 176(3): 1655 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. P. M. Tjin, R. J. Bende, P. W. B. Derksen, A.-P. van Huijstee, H. Kataoka, M. Spaargaren, and S. T. Pals
Follicular Dendritic Cells Catalyze Hepatocyte Growth Factor (HGF) Activation in the Germinal Center Microenvironment by Secreting the Serine Protease HGF Activator
J. Immunol., September 1, 2005; 175(5): 2807 - 2813.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. Meyer-Hermann and P. K. Maini
Cutting Edge: Back to "One-Way" Germinal Centers
J. Immunol., March 1, 2005; 174(5): 2489 - 2493.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-S. Park, S.-O. Yoon, R. J. Armitage, and Y. S. Choi
Follicular Dendritic Cells Produce IL-15 That Enhances Germinal Center B Cell Proliferation in Membrane-Bound Form
J. Immunol., December 1, 2004; 173(11): 6676 - 6683.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. D. Hron, L. Caplan, A. J. Gerth, P. L. Schwartzberg, and S. L. Peng
SH2D1A Regulates T-dependent Humoral Autoimmunity
J. Exp. Med., July 19, 2004; 200(2): 261 - 266.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.