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The Journal of Immunology, 2004, 172: 2827-2833.
Copyright © 2004 by The American Association of Immunologists

Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice1

Nico Ghilardi2,*, Noelyn Kljavin*, Qi Chen{dagger}, Sophie Lucas*, Austin L. Gurney*,{ddagger} and Frederic J. de Sauvage*

Departments of * Molecular Biology, {dagger} Process Sciences, and {ddagger} Immunology, Genentech, South San Francisco, CA 94080

The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12. Previously reported IL-12p40-deficient mice have profound immune defects resulting from combined deficiency in both IL-12 and IL-23. To address the effects of specific IL-23 deficiency, we generated mice lacking p19 by gene targeting. These mice display no overt abnormalities but mount severely compromised T-dependent humoral immune responses. IL-23p19-/- mice produce strongly reduced levels of Ag-specific Igs of all isotypes, but mount normal T-independent B cell responses. In addition, delayed type hypersensitivity responses are strongly impaired in the absence of IL-23, indicating a defect at the level of memory T cells. T cells stimulated with IL-23-deficient APCs secrete significantly reduced amounts of the proinflammatory cytokine IL-17, and IL-23-deficient mice phenotypically resemble IL-17-deficient animals. Thus, IL-23 plays a critical role in T cell-dependent immune responses, and our data provide further support for the existence of an IL-23/IL-17 axis of communication between the adaptive and innate parts of the immune system.


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