| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Unité d’Immunologie, ERM0208 Institut National de la Santé et de la Recherche Médicale, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France;
Centre Jean Godinot, Reims, France;
Unité d’Immunologie Cellulaire Antivirale, Institut Pasteur, Paris, France;
Service de Dermatologie 2, AP-HP Saint Louis, Paris, France;
¶ Stanford University, Stanford Blood Center, Stanford, CA 04304;
|| Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy;
# Department of Tumor Immunology, University Hospital Nijmegen, Nijmegen, The Netherlands;
** Department of Medical Oncology, Velindre Hospital NHS Trust, Cardiff, United Kingdom; and
Service de Neurologie, AP-HP Pitié Salpétrière, Paris, France
Ideal vaccines should be stable, safe, molecularly defined, and out-of-shelf reagents efficient at triggering effector and memory Ag-specific T cell-based immune responses. Dendritic cell-derived exosomes could be considered as novel peptide-based vaccines because exosomes harbor a discrete set of proteins, bear functional MHC class I and II molecules that can be loaded with synthetic peptides of choice, and are stable reagents that were safely used in pioneering phase I studies. However, we showed in part I that exosomes are efficient to promote primary MHC class I-restricted effector CD8+ T cell responses only when transferred onto mature DC in vivo. In this work, we bring evidence that among the clinically available reagents, Toll-like receptor 3 and 9 ligands are elective adjuvants capable of triggering efficient MHC-restricted CD8+ T cell responses when combined to exosomes. Exosome immunogenicity across species allowed to verify the efficacy of good manufactory procedures-manufactured human exosomes admixed with CpG oligonucleotides in prophylactic and therapeutic settings of melanoma in HLA-A2 transgenic mice. CpG adjuvants appear to be ideal adjuvants for exosome-based cancer vaccines.
This article has been cited by other articles:
|
|
 |
|
  M. Terme, G. Mignot, E. Ullrich, M. Bonmort, V. Minard-Colin, A. Jacquet, J. L. Schultze, G. Kroemer, C. Leclerc, N. Chaput, et al. The Dendritic Cell-like Functions of IFN-Producing Killer Dendritic Cells Reside in the CD11b+ Subset and Are Licensed by Tumor Cells Cancer Res., August 15, 2009; 69(16): 6590 - 6597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Coppieters, A. M. Barral, A. Juedes, T. Wolfe, E. Rodrigo, C. Thery, S. Amigorena, and M. G. von Herrath No Significant CTL Cross-Priming by Dendritic Cell-Derived Exosomes during Murine Lymphocytic Choriomeningitis Virus Infection J. Immunol., February 15, 2009; 182(4): 2213 - 2220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nagahara, T. Arikawa, S. Oomizu, K. Kontani, A. Nobumoto, H. Tateno, K. Watanabe, T. Niki, S. Katoh, M. Miyake, et al. Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions J. Immunol., December 1, 2008; 181(11): 7660 - 7669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Clayton, J. P. Mitchell, J. Court, S. Linnane, M. D. Mason, and Z. Tabi Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression J. Immunol., June 1, 2008; 180(11): 7249 - 7258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Terme, N. Chaput, B. Combadiere, A. Ma, T. Ohteki, and L. Zitvogel Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells J. Immunol., April 1, 2008; 180(7): 4679 - 4686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Montecalvo, W. J. Shufesky, D. Beer Stolz, M. G. Sullivan, Z. Wang, S. J. Divito, G. D. Papworth, S. C. Watkins, P. D. Robbins, A. T. Larregina, et al. Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition J. Immunol., March 1, 2008; 180(5): 3081 - 3090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hao, J. Yuan, and J. Xiang Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory J. Leukoc. Biol., October 1, 2007; 82(4): 829 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hao, Y. Liu, J. Yuan, X. Zhang, T. He, X. Wu, Y. Wei, D. Sun, and J. Xiang Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses J. Immunol., September 1, 2007; 179(5): 2731 - 2740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Kim, N. R. Bianco, W. J. Shufesky, A. E. Morelli, and P. D. Robbins MHC Class II+ Exosomes in Plasma Suppress Inflammation in an Antigen-Specific and Fas Ligand/Fas-Dependent Manner J. Immunol., August 15, 2007; 179(4): 2235 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Clayton, J. P. Mitchell, J. Court, M. D. Mason, and Z. Tabi Human Tumor-Derived Exosomes Selectively Impair Lymphocyte Responses to Interleukin-2 Cancer Res., August 1, 2007; 67(15): 7458 - 7466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Segura, C. Guerin, N. Hogg, S. Amigorena, and C. Thery CD8+ Dendritic Cells Use LFA-1 to Capture MHC-Peptide Complexes from Exosomes In Vivo J. Immunol., August 1, 2007; 179(3): 1489 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Colino and C. M. Snapper Dendritic Cell-Derived Exosomes Express a Streptococcus pneumoniae Capsular Polysaccharide Type 14 Cross-Reactive Antigen That Induces Protective Immunoglobulin Responses against Pneumococcal Infection in Mice Infect. Immun., January 1, 2007; 75(1): 220 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tabiasco, E. Devevre, N. Rufer, B. Salaun, J.-C. Cerottini, D. Speiser, and P. Romero Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor J. Immunol., December 15, 2006; 177(12): 8708 - 8713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Dolan, K. D. Gibbs Jr, and S. Ostrand-Rosenberg Dendritic Cells Cross-Dressed with Peptide MHC Class I Complexes Prime CD8+ T Cells J. Immunol., November 1, 2006; 177(9): 6018 - 6024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Colino and C. M. Snapper Exosomes from Bone Marrow Dendritic Cells Pulsed with Diphtheria Toxoid Preferentially Induce Type 1 Antigen-Specific IgG Responses in Naive Recipients in the Absence of Free Antigen J. Immunol., September 15, 2006; 177(6): 3757 - 3762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Chaput, C. Flament, S. Viaud, J. Taieb, S. Roux, A. Spatz, F. Andre, J.-B. LePecq, M. Boussac, J. Garin, et al. Dendritic cell derived-exosomes: biology and clinical implementations J. Leukoc. Biol., September 1, 2006; 80(3): 471 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kovar, O. Boyman, X. Shen, I. Hwang, R. Kohler, and J. Sprent Direct stimulation of T cells by membrane vesicles from antigen-presenting cells PNAS, August 1, 2006; 103(31): 11671 - 11676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Taieb, N. Chaput, N. Schartz, S. Roux, S. Novault, C. Menard, F. Ghiringhelli, M. Terme, A. F. Carpentier, G. Darrasse-Jese, et al. Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines. J. Immunol., March 1, 2006; 176(5): 2722 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Errington, A. Bateman, T. Kottke, J. Thompson, K. Harrington, A. Merrick, P. Hatfield, P. Selby, R. Vile, and A. Melcher Allogeneic Tumor Cells Expressing Fusogenic Membrane Glycoproteins as a Platform for Clinical Cancer Immunotherapy Clin. Cancer Res., February 15, 2006; 12(4): 1333 - 1341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dai, T. Wan, B. Wang, X. Zhou, F. Xiu, T. Chen, Y. Wu, and X. Cao More Efficient Induction of HLA-A*0201-Restricted and Carcinoembryonic Antigen (CEA)-Specific CTL Response by Immunization with Exosomes Prepared from Heat-Stressed CEA-Positive Tumor Cells Clin. Cancer Res., October 15, 2005; 11(20): 7554 - 7563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Bausero, R. Gastpar, G. Multhoff, and A. Asea Alternative Mechanism by which IFN-{gamma} Enhances Tumor Recognition: Active Release of Heat Shock Protein 72 J. Immunol., September 1, 2005; 175(5): 2900 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Clayton, A. Turkes, H. Navabi, M. D. Mason, and Z. Tabi Induction of heat shock proteins in B-cell exosomes J. Cell Sci., August 15, 2005; 118(16): 3631 - 3638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Segura, C. Nicco, B. Lombard, P. Veron, G. Raposo, F. Batteux, S. Amigorena, and C. Thery ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming Blood, July 1, 2005; 106(1): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. J. J. Hegmans, A. Hemmes, J. G. Aerts, H. C. Hoogsteden, and B. N. Lambrecht Immunotherapy of Murine Malignant Mesothelioma Using Tumor Lysate-pulsed Dendritic Cells Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1168 - 1177. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
