The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cervi, L.
Right arrow Articles by Pearce, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cervi, L.
Right arrow Articles by Pearce, E. J.
The Journal of Immunology, 2004, 172: 2016-2020.
Copyright © 2004 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses 1

Laura Cervi*, Andrew S. MacDonald2,*, Colleen Kane*, Florence Dzierszinski{dagger} and Edward J. Pearce3,*

Departments of * Pathobiology and {dagger} Biology, University of Pennsylvania, Philadelphia, PA 19104

To examine the ability of dendritic cells (DC) to discriminate between helminth and microbial Ag and induce appropriately polarized Th responses, mouse DC were copulsed with the helminth Ag, schistosome egg Ag (SEA), along with the bacterium Proprionebacterium acnes, Pa, and transferred into wild-type mice. Strikingly, SEA/Pa-copulsed DC induced concurrent Pa-specific Th1 (but not Th2) responses and SEA-specific Th2 (but not Th1) responses. Although DC exposed to both Ag undergo many of the maturation-associated changes that accompany exposure to Pa alone, Pa-induced IL-12 production was inhibited by SEA. Examination of Ag uptake revealed that SEA and Pa are acquired via discrete pathways and enter nonoverlapping intracellular compartments. Data suggest that segregation of SEA and Pa into distinct compartments, coupled with SEA-induced modifications of the DC maturation pathway, are significant components of the ability of DC to interpret signals inherent to SEA and Pa and induce appropriately polarized Th responses.




This article has been cited by other articles:


Home page
 LupusHome page
G. Zandman-Goddard and Y. Shoenfeld
Parasitic infection and autoimmunity
Lupus, November 1, 2009; 18(13): 1144 - 1148.
[Abstract] [PDF]

Home page
 JEMHome page
B. Everts, G. Perona-Wright, H. H. Smits, C. H. Hokke, A. J. van der Ham, C. M. Fitzsimmons, M. J. Doenhoff, J. van der Bosch, K. Mohrs, H. Haas, et al.
Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
J. Exp. Med., August 3, 2009; 206(8): 1673 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Hamilton, D. J. Dowling, C. E. Loscher, R. M. Morphew, P. M. Brophy, and S. M. O'Neill
The Fasciola hepatica Tegumental Antigen Suppresses Dendritic Cell Maturation and Function
Infect. Immun., June 1, 2009; 77(6): 2488 - 2498.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. D. Kamda and S. M. Singer
Phosphoinositide 3-Kinase-Dependent Inhibition of Dendritic Cell Interleukin-12 Production by Giardia lamblia
Infect. Immun., February 1, 2009; 77(2): 685 - 693.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. G. Shainheit, P. M. Smith, L. E. Bazzone, A. C. Wang, L. I. Rutitzky, and M. J. Stadecker
Dendritic Cell IL-23 and IL-1 Production in Response to Schistosome Eggs Induces Th17 Cells in a Mouse Strain Prone to Severe Immunopathology
J. Immunol., December 15, 2008; 181(12): 8559 - 8567.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Kane, E. Jung, and E. J. Pearce
Schistosoma mansoni Egg Antigen-Mediated Modulation of Toll-Like Receptor (TLR)-Induced Activation Occurs Independently of TLR2, TLR4, and MyD88
Infect. Immun., December 1, 2008; 76(12): 5754 - 5759.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. A. Marshall and E. J. Pearce
Uncoupling of Induced Protein Processing from Maturation in Dendritic Cells Exposed to a Highly Antigenic Preparation from a Helminth Parasite
J. Immunol., December 1, 2008; 181(11): 7562 - 7570.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. S. MacDonald and R. M. Maizels
Alarming dendritic cells for Th2 induction
J. Exp. Med., January 21, 2008; 205(1): 13 - 17.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. L. Graham
Ecological rules governing helminth microparasite coinfection
PNAS, January 15, 2008; 105(2): 566 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. J. Jenkins, G. Perona-Wright, A. G. F. Worsley, N. Ishii, and A. S. MacDonald
Dendritic Cell Expression of OX40 Ligand Acts as a Costimulatory, Not Polarizing, Signal for Optimal Th2 Priming and Memory Induction In Vivo
J. Immunol., September 15, 2007; 179(6): 3515 - 3523.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. J. Ekkens, D. J. Shedlock, E. Jung, A. Troy, E. L. Pearce, H. Shen, and E. J. Pearce
Th1 and Th2 Cells Help CD8 T-Cell Responses
Infect. Immun., May 1, 2007; 75(5): 2291 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Rigano, B. Buttari, E. Profumo, E. Ortona, F. Delunardo, P. Margutti, V. Mattei, A. Teggi, M. Sorice, and A. Siracusano
Echinococcus granulosus Antigen B Impairs Human Dendritic Cell Differentiation and Polarizes Immature Dendritic Cell Maturation towards a Th2 Cell Response
Infect. Immun., April 1, 2007; 75(4): 1667 - 1678.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Balic, Y. M. Harcus, M. D. Taylor, F. Brombacher, and R. M. Maizels
IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance
Int. Immunol., October 1, 2006; 18(10): 1421 - 1431.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. E. Kean, H. S. Goodridge, S. McGuinness, M. M. Harnett, M. J. C. Alcocer, and W. Harnett
Differential Polarization of Immune Responses by Plant 2S Seed Albumins, Ber e 1, and SFA8
J. Immunol., August 1, 2006; 177(3): 1561 - 1566.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A.-M. Sponaas, E. T. Cadman, C. Voisine, V. Harrison, A. Boonstra, A. O'Garra, and J. Langhorne
Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells
J. Exp. Med., June 12, 2006; 203(6): 1427 - 1433.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-C. Chen, S. Louie, B. A. McCormick, W. A. Walker, and H. N. Shi
Helminth-Primed Dendritic Cells Alter the Host Response to Enteric Bacterial Infection
J. Immunol., January 1, 2006; 176(1): 472 - 483.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
N. Y. A. Hemdan, F. Emmrich, K. Adham, G. Wichmann, I. Lehmann, A. El-Massry, H. Ghoneim, J. Lehmann, and U. Sack
Dose-Dependent Modulation of the In Vitro Cytokine Production of Human Immune Competent Cells by Lead Salts
Toxicol. Sci., July 1, 2005; 86(1): 75 - 83.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Z. Su, M. Segura, K. Morgan, J. C. Loredo-Osti, and M. M. Stevenson
Impairment of Protective Immunity to Blood-Stage Malaria by Concurrent Nematode Infection
Infect. Immun., June 1, 2005; 73(6): 3531 - 3539.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Lindstedt, A. Schiott, A. Bengtsson, K. Larsson, M. Korsgren, L. Greiff, and C. A. K. Borrebaeck
Genomic and functional delineation of dendritic cells and memory T cells derived from grass pollen-allergic patients and healthy individuals
Int. Immunol., April 1, 2005; 17(4): 401 - 409.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Kleindienst, C. Wiethe, M. B. Lutz, and T. Brocker
Simultaneous Induction of CD4 T Cell Tolerance and CD8 T Cell Immunity by Semimature Dendritic Cells
J. Immunol., April 1, 2005; 174(7): 3941 - 3947.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Sun, M. Walsh, A. V. Villarino, L. Cervi, C. A. Hunter, Y. Choi, and E. J. Pearce
TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development
J. Immunol., January 15, 2005; 174(2): 742 - 751.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Aksoy, C. S. Zouain, F. Vanhoutte, J. Fontaine, N. Pavelka, N. Thieblemont, F. Willems, P. Ricciardi-Castagnoli, M. Goldman, M. Capron, et al.
Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells
J. Biol. Chem., January 7, 2005; 280(1): 277 - 283.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Kane, L. Cervi, J. Sun, A. S. McKee, K. S. Masek, S. Shapira, C. A. Hunter, and E. J. Pearce
Helminth Antigens Modulate TLR-Initiated Dendritic Cell Activation
J. Immunol., December 15, 2004; 173(12): 7454 - 7461.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.