The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hamerman, J. A.
Right arrow Articles by Lanier, L. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hamerman, J. A.
Right arrow Articles by Lanier, L. L.
The Journal of Immunology, 2004, 172: 2001-2005.
Copyright © 2004 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor 1

Jessica A. Hamerman, Kouetsu Ogasawara and Lewis L. Lanier2

Department of Microbiology and Immunology, and Cancer Research Institute, University of California, San Francisco, CA 94143

Macrophages recognize the presence of infection by using the Toll-like receptor (TLR) family of proteins that detect ligands on bacterial, viral, and fungal pathogens. We show that murine macrophages stimulated with pathogen products known to signal through TLRs express ligands for the NKG2D receptor, found on NK cells, activated CD8+ T cells and activated macrophages. TLR signaling, through the MyD88 adaptor, up-regulates transcription of the retinoic acid early inducible-1 (RAE-1) family of NKG2D ligands, but not H-60 or murine UL16-binding protein-like transcript-1. RAE-1 proteins are found on the surface of activated, but not resting, macrophages and can be detected by NKG2D on NK cells resulting in down-regulation of this receptor both in vitro and in vivo. RAE-1-NKG2D interactions provide a mechanism by which NK cells and infected macrophages communicate directly during an innate immune response to infection.




This article has been cited by other articles:


Home page
 JEMHome page
W. Cao, L. Bover, M. Cho, X. Wen, S. Hanabuchi, M. Bao, D. B. Rosen, Y.-H. Wang, J. L. Shaw, Q. Du, et al.
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
J. Exp. Med., July 6, 2009; 206(7): 1603 - 1614.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Hedlund, A.-C. Stenqvist, O. Nagaeva, L. Kjellberg, M. Wulff, V. Baranov, and L. Mincheva-Nilsson
Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function
J. Immunol., July 1, 2009; 183(1): 340 - 351.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. E. Butler, M. B. Moore, S. R. Presnell, H.-W. Chan, N. J. Chalupny, and C. T. Lutz
Proteasome Regulation of ULBP1 Transcription
J. Immunol., May 15, 2009; 182(10): 6600 - 6609.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
T. Vaisar, S. Y. Kassim, I. G. Gomez, P. S. Green, S. Hargarten, P. J. Gough, W. C. Parks, C. L. Wilson, E. W. Raines, and J. W. Heinecke
MMP-9 Sheds the {beta}2 Integrin Subunit (CD18) from Macrophages
Mol. Cell. Proteomics, May 1, 2009; 8(5): 1044 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Lapaque, T. Walzer, S. Meresse, E. Vivier, and J. Trowsdale
Interactions between Human NK Cells and Macrophages in Response to Salmonella Infection
J. Immunol., April 1, 2009; 182(7): 4339 - 4348.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Cerwenka
New twist on the regulation of NKG2D ligand expression
J. Exp. Med., February 16, 2009; 206(2): 265 - 268.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kloss, P. Decker, K. M. Baltz, T. Baessler, G. Jung, H.-G. Rammensee, A. Steinle, M. Krusch, and H. R. Salih
Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA
J. Immunol., November 15, 2008; 181(10): 6711 - 6719.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Lunemann, J. D. Lunemann, S. Roberts, B. Messmer, R. B. da Silva, C. S. Raine, and C. Munz
Human NK Cells Kill Resting but Not Activated Microglia via NKG2D- and NKp46-Mediated Recognition
J. Immunol., November 1, 2008; 181(9): 6170 - 6177.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. C. Wesselkamper, B. L. Eppert, G. T. Motz, G. W. Lau, D. J. Hassett, and M. T. Borchers
NKG2D Is Critical for NK Cell Activation in Host Defense against Pseudomonas aeruginosa Respiratory Infection
J. Immunol., October 15, 2008; 181(8): 5481 - 5489.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad
Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS
J. Leukoc. Biol., July 1, 2008; 84(1): 1 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. B. Walsh, M. B. Lodoen, R. A. Edwards, L. L. Lanier, and T. E. Lane
Evidence for Differential Roles for NKG2D Receptor Signaling in Innate Host Defense against Coronavirus-Induced Neurological and Liver Disease
J. Virol., March 15, 2008; 82(6): 3021 - 3030.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. B. Walsh, L. L. Lanier, and T. E. Lane
NKG2D Receptor Signaling Enhances Cytolytic Activity by Virus-Specific CD8+ T Cells: Evidence for a Protective Role in Virus-Induced Encephalitis
J. Virol., March 15, 2008; 82(6): 3031 - 3044.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Vales-Gomez, S. E. Chisholm, R. L. Cassady-Cain, P. Roda-Navarro, and H. T. Reyburn
Selective Induction of Expression of a Ligand for the NKG2D Receptor by Proteasome Inhibitors
Cancer Res., March 1, 2008; 68(5): 1546 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Takada, S. Yoshida, M. Kajikawa, Y. Miyatake, U. Tomaru, M. Sakai, H. Chiba, K. Maenaka, D. Kohda, K. Fugo, et al.
Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D
J. Immunol., February 1, 2008; 180(3): 1678 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Brief Funct Genomic ProteomicHome page
G. B. Scott, J. L. Meade, and G. P. Cook
Profiling killers; unravelling the pathways of human natural killer cell function
Brief Funct Genomic Proteomic, January 21, 2008; (2008) elm037v1.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. Ebihara, H. Masuda, T. Akazawa, M. Shingai, H. Kikuta, T. Ariga, M. Matsumoto, and T. Seya
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection
Int. Immunol., October 1, 2007; 19(10): 1145 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips
DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma
J. Immunol., September 15, 2007; 179(6): 3763 - 3771.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Babu, C. P. Blauvelt, and T. B. Nutman
Filarial Parasites Induce NK Cell Activation, Type 1 and Type 2 Cytokine Secretion, and Subsequent Apoptotic Cell Death
J. Immunol., August 15, 2007; 179(4): 2445 - 2456.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Cerboni, A. Zingoni, M. Cippitelli, M. Piccoli, L. Frati, and A. Santoni
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis
Blood, July 15, 2007; 110(2): 606 - 615.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Guan, M. Moretto, D. J. Bzik, J. Gigley, and I. A. Khan
NK Cells Enhance Dendritic Cell Response against Parasite Antigens via NKG2D Pathway
J. Immunol., July 1, 2007; 179(1): 590 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Zhou, H. Wei, R. Sun, J. Zhang, and Z. Tian
NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice
PNAS, May 1, 2007; 104(18): 7512 - 7515.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Nedvetzki, S. Sowinski, R. A. Eagle, J. Harris, F. Vely, D. Pende, J. Trowsdale, E. Vivier, S. Gordon, and D. M. Davis
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
Blood, May 1, 2007; 109(9): 3776 - 3785.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. E. McCann, P. Eissmann, B. Onfelt, R. Leung, and D. M. Davis
The Activating NKG2D Ligand MHC Class I-Related Chain A Transfers from Target Cells to NK Cells in a Manner That Allows Functional Consequences
J. Immunol., March 15, 2007; 178(6): 3418 - 3426.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Akazawa, T. Ebihara, M. Okuno, Y. Okuda, M. Shingai, K. Tsujimura, T. Takahashi, M. Ikawa, M. Okabe, N. Inoue, et al.
Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells
PNAS, January 2, 2007; 104(1): 252 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, M. Vitucci, and D. Cosman
NKG2D ligands are expressed on stressed human airway epithelial cells
Am J Physiol Lung Cell Mol Physiol, August 1, 2006; 291(2): L222 - L231.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Dhanji, M. T. Chow, and H.-S. Teh
Self-Antigen Maintains the Innate Antibacterial Function of Self-Specific CD8 T Cells In Vivo
J. Immunol., July 1, 2006; 177(1): 138 - 146.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, S. Zhang, Y. Chen, L. Young, and G. W. Lau
The NKG2D-Activating Receptor Mediates Pulmonary Clearance of Pseudomonas aeruginosa.
Infect. Immun., May 1, 2006; 74(5): 2578 - 2586.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. D. Bui, L. N. Carayannopoulos, L. L. Lanier, W. M. Yokoyama, and R. D. Schreiber
IFN-Dependent Down-Regulation of the NKG2D Ligand H60 on Tumors
J. Immunol., January 15, 2006; 176(2): 905 - 913.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Nausch, L. Florin, B. Hartenstein, P. Angel, M. Schorpp-Kistner, and A. Cerwenka
Cutting Edge: The AP-1 Subunit JunB Determines NK Cell-Mediated Target Cell Killing by Regulation of the NKG2D-Ligand RAE-1{epsilon}
J. Immunol., January 1, 2006; 176(1): 7 - 11.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. M. Routes, S. Ryan, K. Morris, R. Takaki, A. Cerwenka, and L. L. Lanier
Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection
J. Exp. Med., December 5, 2005; 202(11): 1477 - 1482.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
Y. Lin, Y. Zeng, J. Di, and S. Zeng
Murine CD200+CK7+ trophoblasts in a poly (I:C)-induced embryo resorption model
Reproduction, October 1, 2005; 130(4): 529 - 537.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Vankayalapati, A. Garg, A. Porgador, D. E. Griffith, P. Klucar, H. Safi, W. M. Girard, D. Cosman, T. Spies, and P. F. Barnes
Role of NK Cell-Activating Receptors and Their Ligands in the Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium
J. Immunol., October 1, 2005; 175(7): 4611 - 4617.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. J. Smyth, J. Swann, E. Cretney, N. Zerafa, W. M. Yokoyama, and Y. Hayakawa
NKG2D function protects the host from tumor initiation
J. Exp. Med., September 6, 2005; 202(5): 583 - 588.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. D. Coudert, J. Zimmer, E. Tomasello, M. Cebecauer, M. Colonna, E. Vivier, and W. Held
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
Blood, September 1, 2005; 106(5): 1711 - 1717.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. K. Kriegeskorte, F. E. Gebhardt, S. Porcellini, M. Schiemann, C. Stemberger, T. J. Franz, K. M. Huster, L. N. Carayannopoulos, W. M. Yokoyama, M. Colonna, et al.
NKG2D-independent suppression of T cell proliferation by H60 and MICA
PNAS, August 16, 2005; 102(33): 11805 - 11810.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Rincon-Orozco, V. Kunzmann, P. Wrobel, D. Kabelitz, A. Steinle, and T. Herrmann
Activation of V{gamma}9V{delta}2 T Cells by NKG2D
J. Immunol., August 15, 2005; 175(4): 2144 - 2151.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. A. Dandekar, K. O'Malley, and S. Perlman
Important Roles for Gamma Interferon and NKG2D in {gamma}{delta} T-Cell-Induced Demyelination in T-Cell Receptor {beta}-Deficient Mice Infected with a Coronavirus
J. Virol., August 1, 2005; 79(15): 9388 - 9396.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Wiemann, H.-W. Mittrucker, U. Feger, S. A. Welte, W. M. Yokoyama, T. Spies, H.-G. Rammensee, and A. Steinle
Systemic NKG2D Down-Regulation Impairs NK and CD8 T Cell Responses In Vivo
J. Immunol., July 15, 2005; 175(2): 720 - 729.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Hasan, A. Krmpotic, Z. Ruzsics, I. Bubic, T. Lenac, A. Halenius, A. Loewendorf, M. Messerle, H. Hengel, S. Jonjic, et al.
Selective Down-Regulation of the NKG2D Ligand H60 by Mouse Cytomegalovirus m155 Glycoprotein
J. Virol., March 1, 2005; 79(5): 2920 - 2930.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J.-F. Bach, A. Bendelac, M. B. Brenner, H. Cantor, G. De Libero, M. Kronenberg, L. L. Lanier, D. H. Raulet, M. J. Shlomchik, and M. G. von Herrath
The Role of Innate Immunity in Autoimmunity
J. Exp. Med., December 20, 2004; 200(12): 1527 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. J. Smyth, J. Swann, J. M. Kelly, E. Cretney, W. M. Yokoyama, A. Diefenbach, T. J. Sayers, and Y. Hayakawa
NKG2D Recognition and Perforin Effector Function Mediate Effective Cytokine Immunotherapy of Cancer
J. Exp. Med., November 15, 2004; 200(10): 1325 - 1335.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.