| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses 1
* Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;
The Cooperative Research Centre for Vaccine Technology at The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;
John Curtin School of Medical Research, Australian National University, Canberra, Australia; and
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia
Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8
+ DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC subset priming CTL immunity is restricted to HSV infection or is a more general property of anti-viral immunity was examined. Here, we show that the CD8+ DCs are the principal DC subset that initiates CTL immunity to s.c. infection by influenza virus, HSV, and vaccinia virus. This same subset also dominated immunity after i.v. infection with all three viruses, suggesting a similar involvement in other routes of infection. These data highlight the general role played by CD8+ DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity.
This article has been cited by other articles:
|
|
 |
|
  J. McGill, J. W. Heusel, and K. L. Legge Innate immune control and regulation of influenza virus infections J. Leukoc. Biol., October 1, 2009; 86(4): 803 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chaudhri, B. J. Quah, Y. Wang, A. H. Y. Tan, J. Zhou, G. Karupiah, and C. R. Parish T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control PNAS, September 1, 2009; 106(35): 14984 - 14989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, M. R. G. O'Gorman, H.-F. Bu, V. Koti, X.-L. Zuo, and X.-D. Tan Probiotic Preparation VSL#3 Alters the Distribution and Phenotypes of Dendritic Cells within the Intestinal Mucosa in C57BL/10J Mice J. Nutr., August 1, 2009; 139(8): 1595 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Lukens, D. Kruijsen, F. E. J. Coenjaerts, J. L. L. Kimpen, and G. M. van Bleek Respiratory Syncytial Virus-Induced Activation and Migration of Respiratory Dendritic Cells and Subsequent Antigen Presentation in the Lung-Draining Lymph Node J. Virol., July 15, 2009; 83(14): 7235 - 7243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Wong, L. F. M. Tang, F. C. Lew, H. S. K. Wong, Y. L. Chua, P. A. MacAry, and D. M. Kemeny CD44high Memory CD8 T Cells Synergize with CpG DNA to Activate Dendritic Cell IL-12p70 Production J. Immunol., July 1, 2009; 183(1): 41 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao, C. De Trez, R. Flynn, C. F. Ware, M. Croft, and S. Salek-Ardakani The Adaptor Molecule MyD88 Directly Promotes CD8 T Cell Responses to Vaccinia Virus J. Immunol., May 15, 2009; 182(10): 6278 - 6286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bedoui, S. Prato, J. Mintern, T. Gebhardt, Y. Zhan, A. M. Lew, W. R. Heath, J. A. Villadangos, and E. Segura Characterization of an Immediate Splenic Precursor of CD8+ Dendritic Cells Capable of Inducing Antiviral T Cell Responses J. Immunol., April 1, 2009; 182(7): 4200 - 4207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Qu, V. A. Nguyen, M. Merad, and G. J. Randolph MHC Class I/Peptide Transfer between Dendritic Cells Overcomes Poor Cross-Presentation by Monocyte-Derived APCs That Engulf Dying Cells J. Immunol., March 15, 2009; 182(6): 3650 - 3659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Frleta, C. I. Yu, E. Klechevsky, A.-L. Flamar, G. Zurawski, J. Banchereau, and A. K. Palucka Influenza Virus and Poly(I:C) Inhibit MHC Class I-Restricted Presentation of Cell-Associated Antigens Derived from Infected Dead Cells Captured by Human Dendritic Cells J. Immunol., March 1, 2009; 182(5): 2766 - 2776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Salek-Ardakani, R. Arens, R. Flynn, A. Sette, S. P. Schoenberger, and M. Croft Preferential Use of B7.2 and Not B7.1 in Priming of Vaccinia Virus-Specific CD8 T Cells J. Immunol., March 1, 2009; 182(5): 2909 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Lee, M. Zamora, M. M. Linehan, N. Iijima, D. Gonzalez, A. Haberman, and A. Iwasaki Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection J. Exp. Med., February 16, 2009; 206(2): 359 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Ko, C. Cheng, W.-P. Kong, L. Wang, M. Kanekiyo, D. Einfeld, C. R. King, J. G. D. Gall, and G. J. Nabel Enhanced Induction of Intestinal Cellular Immunity by Oral Priming with Enteric Adenovirus 41 Vectors J. Virol., January 15, 2009; 83(2): 748 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Wolf, D. Buehler, S. E. Hensley, L. L. Cavanagh, E. J. Wherry, P. Kastner, S. Chan, and W. Weninger Plasmacytoid Dendritic Cells Are Dispensable during Primary Influenza Virus Infection J. Immunol., January 15, 2009; 182(2): 871 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ingulli, C. Funatake, E. L. Jacovetty, and M. Zanetti Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection J. Immunol., January 1, 2009; 182(1): 29 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Jirmo, C.-H. Nagel, C. Bohnen, B. Sodeik, and G. M. N. Behrens Contribution of Direct and Cross-Presentation to CTL Immunity against Herpes Simplex Virus 1 J. Immunol., January 1, 2009; 182(1): 283 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bohm, C. O. Simon, J. Podlech, C. K. Seckert, D. Gendig, P. Deegen, D. Gillert-Marien, N. A. W. Lemmermann, R. Holtappels, and M. J. Reddehase The Immune Evasion Paradox: Immunoevasins of Murine Cytomegalovirus Enhance Priming of CD8 T Cells by Preventing Negative Feedback Regulation J. Virol., December 1, 2008; 82(23): 11637 - 11650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hildner, B. T. Edelson, W. E. Purtha, M. Diamond, H. Matsushita, M. Kohyama, B. Calderon, B. U. Schraml, E. R. Unanue, M. S. Diamond, et al. Batf3 Deficiency Reveals a Critical Role for CD8{alpha}+ Dendritic Cells in Cytotoxic T Cell Immunity Science, November 14, 2008; 322(5904): 1097 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Smyth, N. Harker, W. Turnbull, H. El-Doueik, L. Klavinskis, D. Kioussis, G. Lombardi, and R. Lechler The Relative Efficiency of Acquisition of MHC:Peptide Complexes and Cross-Presentation Depends on Dendritic Cell Type J. Immunol., September 1, 2008; 181(5): 3212 - 3220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pulecio, E. Tagliani, A. Scholer, F. Prete, L. Fetler, O. R. Burrone, and F. Benvenuti Expression of Wiskott-Aldrich Syndrome Protein in Dendritic Cells Regulates Synapse Formation and Activation of Naive CD8+ T Cells J. Immunol., July 15, 2008; 181(2): 1135 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Pascual, X. Wang, I. Kochetkova, G. Callis, and C. Riccardi The Absence of Lymphoid CD8+ Dendritic Cell Maturation in L-Selectin-/- Respiratory Compartment Attenuates Antiviral Immunity J. Immunol., July 15, 2008; 181(2): 1345 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. McGill, N. Van Rooijen, and K. L. Legge Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs J. Exp. Med., July 7, 2008; 205(7): 1635 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cook, N. Miyahara, N. Jin, J. M. Wands, C. Taube, C. L. Roark, T. A. Potter, E. W. Gelfand, R. L. O'Brien, and W. K. Born Evidence That CD8+ Dendritic Cells Enable the Development of {gamma}{delta} T Cells That Modulate Airway Hyperresponsiveness J. Immunol., July 1, 2008; 181(1): 309 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tagliani, P. Guermonprez, J. Sepulveda, M. Lopez-Bravo, C. Ardavin, S. Amigorena, F. Benvenuti, and O. R. Burrone Selection of an Antibody Library Identifies a Pathway to Induce Immunity by Targeting CD36 on Steady-State CD8{alpha}+ Dendritic Cells J. Immunol., March 1, 2008; 180(5): 3201 - 3209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Lin, Y. Zhan, A. I. Proietto, S. Prato, L. Wu, W. R. Heath, J. A. Villadangos, and A. M. Lew Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset PNAS, February 26, 2008; 105(8): 3029 - 3034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lopes, M. Dewannieux, U. Gileadi, R. Bailey, Y. Ikeda, C. Whittaker, M. P. Collin, V. Cerundolo, M. Tomihari, K. Ariizumi, et al. Immunization with a Lentivector That Targets Tumor Antigen Expression to Dendritic Cells Induces Potent CD8+ and CD4+ T-Cell Responses J. Virol., January 1, 2008; 82(1): 86 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Basu, S. Bhaumik, A. K. Haldar, K. Naskar, T. De, S. K. Dana, P. Walden, and S. Roy Hybrid Cell Vaccination Resolves Leishmania donovani Infection by Eliciting a Strong CD8+ Cytotoxic T-Lymphocyte Response with Concomitant Suppression of Interleukin-10 (IL-10) but Not IL-4 or IL-13 Infect. Immun., December 1, 2007; 75(12): 5956 - 5966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kupresanin, J. Chow, A. Mount, C. M. Smith, P. G. Stevenson, and G. T. Belz Dendritic Cells Present Lytic Antigens and Maintain Function throughout Persistent {gamma}-Herpesvirus Infection J. Immunol., December 1, 2007; 179(11): 7506 - 7513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Czeloth, A. Schippers, N. Wagner, W. Muller, B. Kuster, G. Bernhardt, and R. Forster Sphingosine-1 Phosphate Signaling Regulates Positioning of Dendritic Cells within the Spleen J. Immunol., November 1, 2007; 179(9): 5855 - 5863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Waithman, R. S. Allan, H. Kosaka, H. Azukizawa, K. Shortman, M. B. Lutz, W. R. Heath, F. R. Carbone, and G. T. Belz Skin-Derived Dendritic Cells Can Mediate Deletional Tolerance of Class I-Restricted Self-Reactive T Cells J. Immunol., October 1, 2007; 179(7): 4535 - 4541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Mathers, O. A. Tckacheva, B. M. Janelsins, W. J. Shufesky, A. E. Morelli, and A. T. Larregina In Vivo Signaling through the Neurokinin 1 Receptor Favors Transgene Expression by Langerhans Cells and Promotes the Generation of Th1- and Tc1-Biased Immune Responses J. Immunol., June 1, 2007; 178(11): 7006 - 7017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Stober, U. G. Lange, M. T. M. Roberts, A. Alcami, and J. M. Blackwell Heterologous Priming-Boosting with DNA and Modified Vaccinia Virus Ankara Expressing Tryparedoxin Peroxidase Promotes Long-Term Memory against Leishmania major in Susceptible BALB/c Mice Infect. Immun., February 1, 2007; 75(2): 852 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Pang, M. T. Sanders, J. J. Monaco, P. C. Doherty, S. J. Turner, and W. Chen Immunoproteasome Subunit Deficiencies Impact Differentially on Two Immunodominant Influenza Virus-Specific CD8+ T Cell Responses J. Immunol., December 1, 2006; 177(11): 7680 - 7688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Bahjat, W. Liu, E. E. Lemmens, S. P. Schoenberger, D. A. Portnoy, T. W. Dubensky Jr., and D. G. Brockstedt Cytosolic Entry Controls CD8+-T-Cell Potency during Bacterial Infection Infect. Immun., November 1, 2006; 74(11): 6387 - 6397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Kornbluth and G. W. Stone Immunostimulatory combinations: designing the next generation of vaccine adjuvants J. Leukoc. Biol., November 1, 2006; 80(5): 1084 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Dolan, K. D. Gibbs Jr, and S. Ostrand-Rosenberg Dendritic Cells Cross-Dressed with Peptide MHC Class I Complexes Prime CD8+ T Cells J. Immunol., November 1, 2006; 177(9): 6018 - 6024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Carter, C. Thompson, D. M. Reid, S. Y. C. Wong, and D. F. Tough Preferential Induction of CD4+ T Cell Responses through In Vivo Targeting of Antigen to Dendritic Cell-Associated C-Type Lectin-1 J. Immunol., August 15, 2006; 177(4): 2276 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Reinhardt, S. Hong, S.-J. Kang, Z.-e. Wang, and R. M. Locksley Visualization of IL-12/23p40 In Vivo Reveals Immunostimulatory Dendritic Cell Migrants that Promote Th1 Differentiation J. Immunol., August 1, 2006; 177(3): 1618 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Munks, M. C. Gold, A. L. Zajac, C. M. Doom, C. S. Morello, D. H. Spector, and A. B. Hill Genome-Wide Analysis Reveals a Highly Diverse CD8 T Cell Response to Murine Cytomegalovirus J. Immunol., March 15, 2006; 176(6): 3760 - 3766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tahara-Hanaoka, K. Shibuya, H. Kai, A. Miyamoto, Y. Morikawa, N. Ohkochi, S.-i. Honda, and A. Shibuya Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor Blood, February 15, 2006; 107(4): 1491 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. van Lint, L. Kleinert, S. R. M. Clarke, A. Stock, W. R. Heath, and F. R. Carbone Latent Infection with Herpes Simplex Virus Is Associated with Ongoing CD8+ T-Cell Stimulation by Parenchymal Cells within Sensory Ganglia J. Virol., December 1, 2005; 79(23): 14843 - 14851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. H. Tan and H. C. O'Neill Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity J. Leukoc. Biol., August 1, 2005; 78(2): 319 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Gordon, F. Li, A. Nayyar, J. Xiang, and X. Zhang CD8{alpha}+, but Not CD8{alpha}-, Dendritic Cells Tolerize Th2 Responses via Contact-Dependent and -Independent Mechanisms, and Reverse Airway Hyperresponsiveness, Th2, and Eosinophil Responses in a Mouse Model of Asthma J. Immunol., August 1, 2005; 175(3): 1516 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Belz, K. Shortman, M. J. Bevan, and W. R. Heath CD8{alpha}+ Dendritic Cells Selectively Present MHC Class I-Restricted Noncytolytic Viral and Intracellular Bacterial Antigens In Vivo J. Immunol., July 1, 2005; 175(1): 196 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chung, J.-H. Chang, M.-N. Kweon, P. D. Rennert, and C.-Y. Kang CD8{alpha}-11b+ dendritic cells but not CD8{alpha}+ dendritic cells mediate cross-tolerance toward intestinal antigens Blood, July 1, 2005; 106(1): 201 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Galibert, G. S. Diemer, Z. Liu, R. S. Johnson, J. L. Smith, T. Walzer, M. R. Comeau, C. T. Rauch, M. F. Wolfson, R. A. Sorensen, et al. Nectin-like Protein 2 Defines a Subset of T-cell Zone Dendritic Cells and Is a Ligand for Class-I-restricted T-cell-associated Molecule J. Biol. Chem., June 10, 2005; 280(23): 21955 - 21964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Heit, F. Schmitz, M. O'Keeffe, C. Staib, D. H. Busch, H. Wagner, and K. M. Huster Protective CD8 T Cell Immunity Triggered by CpG-Protein Conjugates Competes with the Efficacy of Live Vaccines J. Immunol., April 1, 2005; 174(7): 4373 - 4380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lang and J. Nikolich-Zugich Development and Migration of Protective CD8+ T Cells into the Nervous System following Ocular Herpes Simplex Virus-1 Infection J. Immunol., March 1, 2005; 174(5): 2919 - 2925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bondanza, V. S. Zimmermann, P. Rovere-Querini, J. Turnay, I. E. Dumitriu, C. M. Stach, R. E. Voll, U. S. Gaipl, W. Bertling, E. Poschl, et al. Inhibition of Phosphatidylserine Recognition Heightens the Immunogenicity of Irradiated Lymphoma Cells In Vivo J. Exp. Med., November 1, 2004; 200(9): 1157 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, J. Svaren, J. Grayson, and M. Suresh CD8 T Cell Responses to Lymphocytic Choriomeningitis Virus in Early Growth Response Gene 1-Deficient Mice J. Immunol., September 15, 2004; 173(6): 3855 - 3862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Belz, C. M. Smith, L. Kleinert, P. Reading, A. Brooks, K. Shortman, F. R. Carbone, and W. R. Heath Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus PNAS, June 8, 2004; 101(23): 8670 - 8675. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
