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*Substance via MeSH
Medline Plus Health Information
*Dietary Proteins
The Journal of Immunology, 2004, 172: 1515-1523.
Copyright © 2004 by The American Association of Immunologists

Expression of Dual TCR on DO11.10 T Cells Allows for Ovalbumin-Induced Oral Tolerance to Prevent T Cell-Mediated Colitis Directed against Unrelated Enteric Bacterial Antigens1

Pengfei Zhou*, Rajka Borojevic*, Cathy Streutker*, Denis Snider*,{dagger}, Hong Liang*,{dagger} and Kenneth Croitoru2,*

* Intestinal Disease Research Program, Department of Medicine, and {dagger} Department of Molecular Medicine and Pathology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada

The triggering Ag for inflammatory bowel disease and animal models of colitis is not known, but may include gut flora. Feeding OVA to DO11.10 mice with OVA-specific transgenic (Tg) TCR generates Ag-specific immunoregulatory CD4+ T cells (Treg) cells. We examined the ability of oral Ag-induced Treg cells to suppress T cell-mediated colitis in mice. SCID-bg mice given DO11.10 CD4+CD45RBhigh T cells developed colitis, and cotransferring DO11.10 CD45RBlowCD4+ T cells prevented CD4+CD45RBhigh T cell-induced colitis in the absence of OVA. The induction and prevention of disease by DO11.10 CD4+ T cell subsets were associated with an increase in endogenous TCR{alpha} chain expression on Tg T cells. Feeding OVA to SCID-bg mice reconstituted with DO11.10 CD4+CD45RBhigh attenuated the colitis in association with increased TGF-{beta} and IL-10 secretion, and decreased proliferative responses to both OVA and cecal bacteria Ag. OVA feeding also attenuated colitis in SCID-bg mice reconstituted with a mix of BALB/c and DO11.10 CD45RBhigh T cells, suggesting that OVA-induced Treg cells suppressed BALB/c effector cells. The expression of endogenous non-Tg TCR allowed for DO11.10-derived T cells to respond to enteric flora Ag. Furthermore, feeding OVA-induced Treg cells prevented colitis by inducing tolerance in both OVA-reactive and non-OVA-reactive T cells and by inducing Ag-nonspecific Treg cells. Such a mechanism might allow for Ag-nonspecific modulation of intestinal inflammation in inflammatory bowel disease.




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