| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice
* Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
In previous studies, we have shown that murine CD4+CD25+ regulatory T cells produce high levels of TGF-
1 in a cell surface and/or secreted form, and blockade of such TGF-1 by anti-TGF- curtails the ability of these cells to suppress CD25- T cell proliferation and B cell Ig production in in vitro suppressor assays. In further support for the role of TGF-1 in suppression by CD4+CD25+ T cells, we show in this study that another TGF-1-blocking molecule, recombinant latency-associated peptide of TGF-1 (rLAP), also reverses suppression by mouse CD4+CD25+ T cells as well as their human counterparts, CD4+CD25high T cells. In addition, we show that CD25- T cells exposed to CD4+CD25+ T cells in vitro manifest activation of Smad-2 and induction of CD103, the latter a TGF--inducible surface integrin. In further studies, we show that while CD4+CD25+ T cells from TGF-1-deficient mice can suppress CD25- T cell proliferation in vitro, these cells do not protect recipient mice from colitis in the SCID transfer model in vivo, and, in addition, CD4+LAP+, but not CD4+LAP- T cells from normal mice protect recipient mice from colitis in this model. Together, these studies demonstrate that TGF-1 produced by CD4+CD25+ T cells is involved in the suppressor activity of these cells, particularly in their ability to regulate intestinal inflammation.
This article has been cited by other articles:
|
|
 |
|
  J. Andersson, D. Q. Tran, M. Pesu, T. S. Davidson, H. Ramsey, J. J. O'Shea, and E. M. Shevach CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-{beta}-dependent manner J. Exp. Med., September 1, 2008; 205(9): 1975 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. L. Savage, T. de Boer, K. V. Walburg, S. A. Joosten, K. van Meijgaarden, A. Geluk, and T. H. M. Ottenhoff Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGF{beta}-1 J. Immunol., August 1, 2008; 181(3): 2220 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Cardoso, G. P. Garlet, A. P. Moreira, W. M. Junior, M. A. Rossi, and J. S. Silva Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis J. Leukoc. Biol., July 1, 2008; 84(1): 311 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gil-Guerrero, J. Dotor, I. L. Huibregtse, N. Casares, A. B. Lopez-Vazquez, F. Rudilla, J. I. Riezu-Boj, J. Lopez-Sagaseta, J. Hermida, S. Van Deventer, et al. In Vitro and In Vivo Down-Regulation of Regulatory T Cell Activity with a Peptide Inhibitor of TGF-{beta}1 J. Immunol., July 1, 2008; 181(1): 126 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Chen, B.-S. Yan, Y. Bando, V. K. Kuchroo, and H. L. Weiner Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF{beta}-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis J. Immunol., June 1, 2008; 180(11): 7327 - 7337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Perez, S. Karumuthil-Melethil, R. Li, B. S. Prabhakar, M. J. Holterman, and C. Vasu Preferential Costimulation by CD80 Results in IL-10-Dependent TGF-{beta}1+-Adaptive Regulatory T Cell Generation J. Immunol., May 15, 2008; 180(10): 6566 - 6576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Larmonier, J. Cantrell, C. LaCasse, G. Li, N. Janikashvili, E. Situ, M. Sepassi, S. Andreansky, and E. Katsanis Chaperone-rich tumor cell lysate-mediated activation of antigen-presenting cells resists regulatory T cell suppression J. Leukoc. Biol., April 1, 2008; 83(4): 1049 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Sumpter, K. K. Payne, and D. S. Wilkes Regulation of the NFAT pathway discriminates CD4+CD25+ regulatory T cells from CD4+CD25- helper T cells J. Leukoc. Biol., March 1, 2008; 83(3): 708 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Asano, T. Watanabe, A. Kitani, I. J. Fuss, and W. Strober Notch1 Signaling and Regulatory T Cell Function J. Immunol., March 1, 2008; 180(5): 2796 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Singh, A. La Cava, and B. H. Hahn pConsensus Peptide Induces Tolerogenic CD8+ T Cells in Lupus-Prone (NZB x NZW)F1 Mice by Differentially Regulating Foxp3 and PD1 Molecules J. Immunol., February 15, 2008; 180(4): 2069 - 2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Das and A. D. Levine TGF-{beta} Inhibits IL-2 Production and Promotes Cell Cycle Arrest in TCR-Activated Effector/Memory T Cells in the Presence of Sustained TCR Signal Transduction J. Immunol., February 1, 2008; 180(3): 1490 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Singh, H. H. Zhang, J. F. Foley, M. N. Hedrick, and J. M. Farber Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6 J. Immunol., January 1, 2008; 180(1): 214 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Reynolds, R. Banerjee, J. Liu, H. E. Gendelman, and R. L. Mosley Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease J. Leukoc. Biol., November 1, 2007; 82(5): 1083 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Derks, E. Jankowska-Gan, Q. Xu, and W. J. Burlingham Dendritic Cell Type Determines the Mechanism of Bystander Suppression by Adaptive T Regulatory Cells Specific for the Minor Antigen HA-1 J. Immunol., September 15, 2007; 179(6): 3443 - 3451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Oberle, N. Eberhardt, C. S. Falk, P. H. Krammer, and E. Suri-Payer Rapid Suppression of Cytokine Transcription in Human CD4+CD25 T Cells by CD4+Foxp3+ Regulatory T Cells: Independence of IL-2 Consumption, TGF-beta, and Various Inhibitors of TCR Signaling J. Immunol., September 15, 2007; 179(6): 3578 - 3587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Kapp, K. Honjo, L. M. Kapp, K. Goldsmith, and R. P. Bucy Antigen, in the Presence of TGF-beta, Induces Up-Regulation of FoxP3gfp+ in CD4+ TCR Transgenic T Cells That Mediate Linked Suppression of CD8+ T Cell Responses J. Immunol., August 15, 2007; 179(4): 2105 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Clayton, J. P. Mitchell, J. Court, M. D. Mason, and Z. Tabi Human Tumor-Derived Exosomes Selectively Impair Lymphocyte Responses to Interleukin-2 Cancer Res., August 1, 2007; 67(15): 7458 - 7466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pyzik and C. A. Piccirillo TGF-{beta}1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets J. Leukoc. Biol., August 1, 2007; 82(2): 335 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Strauss, C. Bergmann, M. Szczepanski, W. Gooding, J. T. Johnson, and T. L. Whiteside A Unique Subset of CD4+CD25highFoxp3+ T Cells Secreting Interleukin-10 and Transforming Growth Factor-{beta}1 Mediates Suppression in the Tumor Microenvironment Clin. Cancer Res., August 1, 2007; 13(15): 4345 - 4354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Yates, A. M. Paterson, K. F. Nolan, S. P. Cobbold, N. J. Saunders, H. Waldmann, and P. J. Fairchild Induction of Regulatory T Cells and Dominant Tolerance by Dendritic Cells Incapable of Full Activation J. Immunol., July 15, 2007; 179(2): 967 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Stephens, J. Andersson, and E. M. Shevach Distinct Subsets of FoxP3+ Regulatory T Cells Participate in the Control of Immune Responses J. Immunol., June 1, 2007; 178(11): 6901 - 6911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Pop, C. P. Wong, Q. He, Y. Wang, M. A. Wallet, K. S. Goudy, and R. Tisch The Type and Frequency of Immunoregulatory CD4+ T-Cells Govern the Efficacy of Antigen-Specific Immunotherapy in Nonobese Diabetic Mice Diabetes, May 1, 2007; 56(5): 1395 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. You, B. Leforban, C. Garcia, J.-F. Bach, J. A. Bluestone, and L. Chatenoud Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment PNAS, April 10, 2007; 104(15): 6335 - 6340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gandhi, D. E. Anderson, and H. L. Weiner Cutting Edge: Immature Human Dendritic Cells Express Latency-Associated Peptide and Inhibit T Cell Activation in a TGF-beta-Dependent Manner J. Immunol., April 1, 2007; 178(7): 4017 - 4021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Hilchey, A. De, L. M. Rimsza, R. B. Bankert, and S. H. Bernstein Follicular Lymphoma Intratumoral CD4+CD25+GITR+ Regulatory T Cells Potently Suppress CD3/CD28-Costimulated Autologous and Allogeneic CD8+CD25- and CD4+CD25- T Cells J. Immunol., April 1, 2007; 178(7): 4051 - 4061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. MacKenzie, J. Schartner, J. Lin, A. Timmel, M. Jennens-Clough, C. G. Fathman, and C. M. Seroogy GRAIL Is Up-regulated in CD4+ CD25+ T Regulatory Cells and Is Sufficient for Conversion of T Cells to a Regulatory Phenotype J. Biol. Chem., March 30, 2007; 282(13): 9696 - 9702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Berhanu, J. Huang, S. C. Watkins, H. Okada, and W. J. Storkus Treatment-Enhanced CD4+Foxp3+ Glucocorticoid-Induced TNF Receptor Family RelatedHigh Regulatory Tumor-Infiltrating T Cells Limit the Effectiveness of Cytokine-Based Immunotherapy J. Immunol., March 15, 2007; 178(6): 3400 - 3408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Xu, J. Lee, E. Jankowska-Gan, J. Schultz, D. A. Roennburg, L. D. Haynes, S. Kusaka, H. W. Sollinger, S. J. Knechtle, A. M. VanBuskirk, et al. Human CD4+CD25low Adaptive T Regulatory Cells Suppress Delayed-Type Hypersensitivity during Transplant Tolerance J. Immunol., March 15, 2007; 178(6): 3983 - 3995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stein-Streilein and A. W. Taylor An eye's view of T regulatory cells J. Leukoc. Biol., March 1, 2007; 81(3): 593 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Elrefaei, F. L. Ventura, C. A. R. Baker, R. Clark, D. R. Bangsberg, and H. Cao HIV-Specific IL-10-Positive CD8+ T Cells Suppress Cytolysis and IL-2 Production by CD8+ T Cells J. Immunol., March 1, 2007; 178(5): 3265 - 3271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Beiting, L. F. Gagliardo, M. Hesse, S. K. Bliss, D. Meskill, and J. A. Appleton Coordinated Control of Immunity to Muscle Stage Trichinella spiralis by IL-10, Regulatory T Cells, and TGF-beta J. Immunol., January 15, 2007; 178(2): 1039 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Golshayan, S. Jiang, J. Tsang, M. I. Garin, C. Mottet, and R. I. Lechler In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance Blood, January 15, 2007; 109(2): 827 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bodor, Z. Fehervari, B. Diamond, and S. Sakaguchi Regulatory T cell-mediated suppression: potential role of ICER J. Leukoc. Biol., January 1, 2007; 81(1): 161 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Sukiennicki and D. J. Fowell Distinct Molecular Program Imposed on CD4+ T Cell Targets by CD4+CD25+ Regulatory T Cells J. Immunol., November 15, 2006; 177(10): 6952 - 6961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lewkowicz, N. Lewkowicz, A. Sasiak, and H. Tchorzewski Lipopolysaccharide-Activated CD4+CD25+ T Regulatory Cells Inhibit Neutrophil Function and Promote Their Apoptosis and Death J. Immunol., November 15, 2006; 177(10): 7155 - 7163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Cavassani, A. P. Campanelli, A. P. Moreira, J. O. Vancim, L. H. Vitali, R. C. Mamede, R. Martinez, and J. S. Silva Systemic and Local Characterization of Regulatory T Cells in a Chronic Fungal Infection in Humans J. Immunol., November 1, 2006; 177(9): 5811 - 5818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-W. Xia, W.-W. Zhong, L.-Q. Xu, J.-L. Sun, Q.-X. Shen, J.-G. Wang, J. Shao, Y.-Z. Li, and S.-C. Yu Heme Oxygenase-1-Mediated CD4+CD25high Regulatory T Cells Suppress Allergic Airway Inflammation J. Immunol., November 1, 2006; 177(9): 5936 - 5945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Leeto, D. R. Herbert, R. Marillier, A. Schwegmann, L. Fick, and F. Brombacher TH1-Dominant Granulomatous Pathology Does Not Inhibit Fibrosis or Cause Lethality during Murine Schistosomiasis Am. J. Pathol., November 1, 2006; 169(5): 1701 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Kapp, K. Honjo, L. M. Kapp, X. y. Xu, A. Cozier, and R. P. Bucy TCR transgenic CD8+ T cells activated in the presence of TGF{beta} express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection Int. Immunol., November 1, 2006; 18(11): 1549 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Melencio, R. J. McKallip, H. Guan, R. Ramakrishnan, R. Jain, P. S. Nagarkatti, and M. Nagarkatti Role of CD4+CD25+ T regulatory cells in IL-2-induced vascular leak Int. Immunol., October 1, 2006; 18(10): 1461 - 1471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lopez, M. R. Clarkson, M. Albin, M. H. Sayegh, and N. Najafian A Novel Mechanism of Action for Anti-Thymocyte Globulin: Induction of CD4+CD25+Foxp3+ Regulatory T Cells J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2844 - 2853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gianfrani, M. K. Levings, C. Sartirana, G. Mazzarella, G. Barba, D. Zanzi, A. Camarca, G. Iaquinto, N. Giardullo, S. Auricchio, et al. Gliadin-Specific Type 1 Regulatory T Cells from the Intestinal Mucosa of Treated Celiac Patients Inhibit Pathogenic T Cells J. Immunol., September 15, 2006; 177(6): 4178 - 4186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Toda and C. A. Piccirillo Development and function of naturally occurring CD4+CD25+ regulatory T cells J. Leukoc. Biol., September 1, 2006; 80(3): 458 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oida, L. Xu, H. L. Weiner, A. Kitani, and W. Strober TGF-beta-Mediated Suppression by CD4+CD25+ T Cells Is Facilitated by CTLA-4 Signaling J. Immunol., August 15, 2006; 177(4): 2331 - 2339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tang, Z. Guo, M. Zhang, J. Wang, G. Chen, and X. Cao Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10 Blood, August 15, 2006; 108(4): 1189 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rezvani, S. Mielke, M. Ahmadzadeh, Y. Kilical, B. N. Savani, J. Zeilah, K. Keyvanfar, A. Montero, N. Hensel, R. Kurlander, et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT Blood, August 15, 2006; 108(4): 1291 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Metwali, T. Setiawan, A. M. Blum, J. Urban, D. E. Elliott, L. Hang, and J. V. Weinstock Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G253 - G259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Moos, D. Kunkel, T. Marth, G. E. Feurle, B. LaScola, R. Ignatius, M. Zeitz, and T. Schneider Reduced Peripheral and Mucosal Tropheryma whipplei-Specific Th1 Response in Patients with Whipple's Disease J. Immunol., August 1, 2006; 177(3): 2015 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Li, A. Rosendahl, G. Brodin, A. M. Cheng, A. Ahgren, C. Sundquist, S. Kulkarni, T. Pawson, C.-H. Heldin, and R. L. Heuchel Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses. J. Immunol., June 1, 2006; 176(11): 6777 - 6784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Duchmann and M Zeitz T regulatory cell suppression of colitis: the role of TGF-{beta} Gut, May 1, 2006; 55(5): 604 - 606. [Full Text] [PDF]
|
|
|
|
|
|
Z.-Z. Yang, A. J. Novak, M. J. Stenson, T. E. Witzig, and S. M. Ansell Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma Blood, May 1, 2006; 107(9): 3639 - 3646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, J. Reddy, H. Ochi, D. Frenkel, V. K. Kuchroo, and H. L. Weiner Recovery from experimental allergic encephalomyelitis is TGF-{beta} dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells Int. Immunol., April 1, 2006; 18(4): 495 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Longhi, M. J. Hussain, R. R. Mitry, S. K. Arora, G. Mieli-Vergani, D. Vergani, and Y. Ma Functional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis J. Immunol., April 1, 2006; 176(7): 4484 - 4491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chen, W.-h. Lee, L. Zhong, and C.-P. Liu Regulatory T Cells Can Mediate Their Function through the Stimulation of APCs to Produce Immunosuppressive Nitric Oxide J. Immunol., March 15, 2006; 176(6): 3449 - 3460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Suvas, A. K. Azkur, and B. T. Rouse Qa-1b and CD94-NKG2a Interaction Regulate Cytolytic Activity of Herpes Simplex Virus-Specific Memory CD8+ T Cells in the Latently Infected Trigeminal Ganglia J. Immunol., February 1, 2006; 176(3): 1703 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-A. Alyanakian, F. Grela, A. Aumeunier, C. Chiavaroli, C. Gouarin, E. Bardel, G. Normier, L. Chatenoud, N. Thieblemont, and J.-F. Bach Transforming Growth Factor-{beta} and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes Diabetes, January 1, 2006; 55(1): 179 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. C. Rogner, F. Lepault, M.-C. Gagnerault, D. Vallois, J. Morin, P. Avner, and C. Boitard The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells Diabetes, January 1, 2006; 55(1): 186 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sugita, T. F. Ng, P. J. Lucas, R. E. Gress, and J. W. Streilein B7+ Iris Pigment Epithelium Induce CD8+ T Regulatory Cells; Both Suppress CTLA-4+ T Cells J. Immunol., January 1, 2006; 176(1): 118 - 127. [Abstract] [Full Text] [PDF]
|
|
