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CUTTING EDGE |
B2 Is a Negative Regulator of Dendritic Cell Function1
* Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104; and
Medical Research Council Centre for Immune Regulation, School of Medicine, University of Birmingham, Edgbaston, Birmingham, United Kingdom
RelB, a member of the NF-
B family of transcription factors, is essential for dendritic cell (DC) maturation. Recent findings indicate that RelB is exclusively regulated through its interaction with cytoplasmic NF-B2/p100. The studies presented in this report show that DCs lacking NF-B2 have dramatically enhanced RelB activity, associated with increased MHC class II and costimulatory molecule expression and an enhanced ability to induce CD4+ T cell responses. These studies identify a novel role for NF-B2 in the negative regulation of RelB-induced DC maturation, with critical consequences for the regulation of adaptive immune responses.
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