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The Journal of Immunology, 2004, 172: 1146-1156.
Copyright © 2004 by The American Association of Immunologists

The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization1

Donald J. Davidson2,3,*,{dagger}, Andrew J. Currie3,*, Gregor S. D. Reid*, Dawn M. E. Bowdish{dagger}, Kelly L. MacDonald*, Rebecca C. Ma*, Robert E. W. Hancock{dagger} and David P. Speert*,{dagger}

* British Columbia Research Institute for Child and Family Health, and {dagger} Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

Dendritic cells (DC) are instrumental in orchestrating an appropriately polarized Th cell response to pathogens. DC exhibit considerable phenotypic and functional plasticity, influenced by lineage, Ag engagement, and the environment in which they develop and mature. In this study, we identify the human cationic peptide LL-37, found in abundance at sites of inflammation, as a potent modifier of DC differentiation, bridging innate and adaptive immune responses. LL-37-derived DC displayed significantly up-regulated endocytic capacity, modified phagocytic receptor expression and function, up-regulated costimulatory molecule expression, enhanced secretion of Th-1 inducing cytokines, and promoted Th1 responses in vitro. LL-37 may be an attractive therapeutic candidate for manipulating T cell polarization by DC.




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