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Initial Antigen Encounter Programs CD8⁺ T Cells Competent to Develop into Memory Cells That Are Activated in an Antigen-Free, IL-7- and IL-15-Rich Environment¹

Roberto Carrio^*, Oliver F. Bathe and Thomas R. Malek^2,*

^* Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101; and Department of Surgery and Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, Canada

Although much is known concerning the immunobiology of CD8⁺ T memory cells, the initial events favoring the generation of CD8⁺ T memory cells remain poorly defined. Using a culture system that yields memory-like CD8⁺ T cells, we show that 1 day after Ag encounter, Ag-activated T cells developed into memory-like T cells, but this optimally occurred 3 days after Ag encounter. Key phenotypic, functional, and molecular properties that typify central memory T cells were expressed within 48 h when the activated CD8⁺ T cells were cultured with IL-7 or IL-15 in the absence of Ag or following transfer into normal mice. These data support a model whereby Ag activation of naive CD8⁺ T cells not only programs effector cell expansion and contraction but the potential to develop into a memory cell which ensues in an Ag-free environment containing IL-7 or IL-15.

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The JI 2004 172: 7227-7228. [Full Text]  

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