| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Production in Human T Cells and NK Cells1
* Cedars-Sinai Inflammatory Bowel Disease Center, Los Angeles, CA 90048; and
Human Genome Sciences, Rockville, MD 20850
TL1A, a recently described TNF-like cytokine that interacts with DR3, costimulates T cells and augments anti-CD3 plus anti-CD28 IFN-
production. In the current study we show that TL1A or an agonistic anti-DR3 mAb synergize with IL-12/IL-18 to augment IFN- production in human peripheral blood T cells and NK cells. TL1A also enhanced IFN- production by IL-12/IL-18 stimulated CD56+ T cells. When expressed as fold change, the synergistic effect of TL1A on cytokine-induced IFN- production was more pronounced on CD4+ and CD8+ T cells than on CD56+ T cells or NK cells. Intracellular cytokine staining showed that TL1A significantly enhanced both the percentage and the mean fluorescence intensity of IFN--producing T cells in response to IL-12/IL-18. The combination of IL-12 and IL-18 markedly up-regulated DR3 expression in NK cells, whereas it had minimal effect in T cells. Our data suggest that TL1A/DR3 pathway plays an important role in the augmentation of cytokine-induced IFN- production in T cells and that DR3 expression is differentially regulated by IL-12/IL-18 in T cells and NK cells.
This article has been cited by other articles:
|
|
 |
|
  J. Zhang, X. Wang, H. Fahmi, S. Wojcik, J. Fikes, Y. Yu, J. Wu, and H. Luo Role of TL1A in the Pathogenesis of Rheumatoid Arthritis J. Immunol., October 15, 2009; 183(8): 5350 - 5357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Tian, P. H. Liang, and L.-Y. Li Inhibition of endothelial progenitor cell differentiation by VEGI Blood, May 21, 2009; 113(21): 5352 - 5360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sattler, U. Wagner, M. Rossol, J. Sieper, P. Wu, A. Krause, W. A. Schmidt, S. Radmer, S. Kohler, C. Romagnani, et al. Cytokine-induced human IFN-{gamma}-secreting effector-memory Th cells in chronic autoimmune inflammation Blood, February 26, 2009; 113(9): 1948 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Pappu, A. Borodovsky, T. S. Zheng, X. Yang, P. Wu, X. Dong, S. Weng, B. Browning, M. L. Scott, L. Ma, et al. TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease J. Exp. Med., May 12, 2008; 205(5): 1049 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fang, B. Adkins, V. Deyev, and E. R. Podack Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation J. Exp. Med., May 12, 2008; 205(5): 1037 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Cohavy and S. R. Targan CD56 Marks an Effector T Cell Subset in the Human Intestine J. Immunol., May 1, 2007; 178(9): 5524 - 5532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Prehn, L. S. Thomas, C. J. Landers, Q. T. Yu, K. S. Michelsen, and S. R. Targan The T Cell Costimulator TL1A Is Induced by Fc{gamma}R Signaling in Human Monocytes and Dendritic Cells J. Immunol., April 1, 2007; 178(7): 4033 - 4038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saruta, Q. T. Yu, A. Avanesyan, P. R. Fleshner, S. R. Targan, and K. A. Papadakis Phenotype and Effector Function of CC Chemokine Receptor 9-Expressing Lymphocytes in Small Intestinal Crohn's Disease J. Immunol., March 1, 2007; 178(5): 3293 - 3300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bamias, M. Mishina, M. Nyce, W. G. Ross, G. Kollias, J. Rivera-Nieves, T. T. Pizarro, and F. Cominelli From the Cover: Role of TL1A and its receptor DR3 in two models of chronic murine ileitis PNAS, May 30, 2006; 103(22): 8441 - 8446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Young and M. G. Tovey TL1A: A mediator of gut inflammation PNAS, May 30, 2006; 103(22): 8303 - 8304. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Hou, D. Medynski, S. Wu, X. Lin, and L.-Y. Li VEGI-192, a New Isoform of TNFSF15, Specifically Eliminates Tumor Vascular Endothelial Cells and Suppresses Tumor Growth Clin. Cancer Res., August 1, 2005; 11(15): 5595 - 5602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Papadakis, D. Zhu, J. L. Prehn, C. Landers, A. Avanesyan, G. Lafkas, and S. R. Targan Dominant Role for TL1A/DR3 Pathway in IL-12 plus IL-18-Induced IFN-{gamma} Production by Peripheral Blood and Mucosal CCR9+ T Lymphocytes J. Immunol., April 15, 2005; 174(8): 4985 - 4990. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
