HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) A correction has been published Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Das, H. Articles by Brenner, M. B. Search for Related Content PubMed PubMed Citation Articles by Das, H. Articles by Brenner, M. B.

Mechanisms of V1 T Cell Activation by Microbial Components¹

Hiranmoy Das^*, Masahiko Sugita and Michael B. Brenner^2,*

^* Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115; and Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan

There are two major subsets of T cell in humans. V2V2 T cells predominate in the circulation and significantly expand in vivo during a variety of infectious diseases. Ags identified for the V2 T cells are nonpeptide phosphate, amine, and aminobisphosphonate compounds. In contrast, V1-encoded TCRs account for the vast majority of T cells in tissues such as intestine and spleen. Some of these T cells recognize CD1c and MHC class I-related chain B molecules. These T cells are cytotoxic and use both perforin- and Fas-mediated cytotoxicity. A fundamental question is how these T cells are activated during microbial exposure to carry out effector functions. In this study, we provide evidence for a mechanism by which V1 T cells are activated by inflammatory cytokines in the context of the V1 TCR. Dendritic cells are necessary as accessory cells for microbial Ag-mediated V1 T cell activation. Cytokine (IL-12), adhesion (LFA3/CD2, LFA1/ICAM1) and costimulatory (MHC class I-related chain B molecule/NK-activating receptor G2D) molecules play a significant role along with V1 TCR in this activation.

This article has been cited by other articles:

				C.-H. Kim, D. A. Witherden, and W. L. Havran Characterization and TCR variable region gene use of mouse resident nasal {gamma}{delta} T lymphocytes J. Leukoc. Biol., November 1, 2008; 84(5): 1259 - 1263. [Abstract] [Full Text] [PDF]

				H. Das, A. Kumar, Z. Lin, W. D. Patino, P. M. Hwang, M. W. Feinberg, P. K. Majumder, and M. K. Jain Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes PNAS, April 25, 2006; 103(17): 6653 - 6658. [Abstract] [Full Text] [PDF]

				O. Zachariadis, J. P. Cassidy, J. Brady, and B. P. Mahon {gamma}{delta} T Cells Regulate the Early Inflammatory Response to Bordetella pertussis Infection in the Murine Respiratory Tract Infect. Immun., March 1, 2006; 74(3): 1837 - 1845. [Abstract] [Full Text] [PDF]

				J. F. Hedges, K. J. Lubick, and M. A. Jutila {gamma}{delta} T Cells Respond Directly to Pathogen-Associated Molecular Patterns J. Immunol., May 15, 2005; 174(10): 6045 - 6053. [Abstract] [Full Text] [PDF]

				A. N. Rogers, D. G. VanBuren, E. E. Hedblom, M. E. Tilahun, J. C. Telfer, and C. L. Baldwin {gamma}{delta} T Cell Function Varies with the Expressed WC1 Coreceptor J. Immunol., March 15, 2005; 174(6): 3386 - 3393. [Abstract] [Full Text] [PDF]

				K. K. Lahmers, J. Norimine, M. S. Abrahamsen, G. H. Palmer, and W. C. Brown The CD4+ T cell immunodominant Anaplasma marginale major surface protein 2 stimulates {gamma}{delta} T cell clones that express unique T cell receptors J. Leukoc. Biol., February 1, 2005; 77(2): 199 - 208. [Abstract] [Full Text] [PDF]