The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thornton, A. M.
Right arrow Articles by Shevach, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thornton, A. M.
Right arrow Articles by Shevach, E. M.
The Journal of Immunology, 2004, 172: 6519-6523.
Copyright © 2004 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

Angela M. Thornton1, Erin E. Donovan, Ciriaco A. Piccirillo2 and Ethan M. Shevach

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

CD4+CD25+ T cells are potent immunoregulatory cells that suppress TCR-induced proliferation of CD4 and CD8 T cells in vitro by a cell contact-dependent mechanism. Addition of IL-2 or anti-CD28 abrogates CD4+CD25+-mediated suppression of proliferation and has been assumed to "break suppression." We examined IL-2 mRNA by quantitative PCR in cocultures of mouse CD4+CD25+ and CD4+CD25– T cells. Although IL-2 gene transcription was inhibited in the presence or absence of exogenous IL-2, the addition of anti-CD28 stimulated endogenous IL-2 production. Surprisingly, transcription of IL-2 mRNA was also restored in the cocultures in the presence of anti-IL-2. These results are most compatible with a model in which CD4+CD25+ T cells do not suppress the initial activation of CD4+CD25– T cells, but mediate their suppressive effects following production of IL-2 by the responder cells resulting in both the expansion of the CD4+CD25+ T cells and the induction of their suppressor function.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
H. Inaba, M. Steeves, P. Nguyen, and T. L. Geiger
In Vivo Suppression of Naive CD4 T Cell Responses by IL-2- and Antigen-Stimulated T Lymphocytes in the Absence of APC Competition
J. Immunol., September 1, 2008; 181(5): 3323 - 3335.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Sehrawat, S. Suvas, P. P. Sarangi, A. Suryawanshi, and B. T. Rouse
In Vitro-Generated Antigen-Specific CD4+ CD25+ Foxp3+ Regulatory T Cells Control the Severity of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions
J. Virol., July 15, 2008; 82(14): 6838 - 6851.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A.-S. Dugast, T. Haudebourg, F. Coulon, M. Heslan, F. Haspot, N. Poirier, R. Vuillefroy de Silly, C. Usal, H. Smit, B. Martinet, et al.
Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion
J. Immunol., June 15, 2008; 180(12): 7898 - 7906.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Ouabed, F.-X. Hubert, D. Chabannes, L. Gautreau, M. Heslan, and R. Josien
Differential Control of T Regulatory Cell Proliferation and Suppressive Activity by Mature Plasmacytoid versus Conventional Spleen Dendritic Cells
J. Immunol., May 1, 2008; 180(9): 5862 - 5870.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. Passerini, S. E. Allan, M. Battaglia, S. Di Nunzio, A. N. Alstad, M. K. Levings, M. G. Roncarolo, and R. Bacchetta
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells
Int. Immunol., March 1, 2008; 20(3): 421 - 431.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kashyap, A. M. Thornton, S. K. Norton, B. Barnstein, M. Macey, J. Brenzovich, E. Shevach, W. J. Leonard, and J. J. Ryan
Cutting Edge: CD4 T Cell-Mast Cell Interactions Alter IgE Receptor Expression and Signaling
J. Immunol., February 15, 2008; 180(4): 2039 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. C. Ruzek, J. S. Waire, D. Hopkins, G. LaCorcia, J. Sullivan, B. L. Roberts, S. M. Richards, S. R. Nahill, J. M. Williams, A. Scaria, et al.
Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo
Blood, February 1, 2008; 111(3): 1726 - 1734.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Li, E. J. Gowans, C. Chougnet, M. Plebanski, and U. Dittmer
Natural Regulatory T Cells and Persistent Viral Infection
J. Virol., January 1, 2008; 82(1): 21 - 30.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
K. G. Elpek, E. S. Yolcu, D. D. H. Franke, C. Lacelle, R.-H. Schabowsky, and H. Shirwan
Ex Vivo Expansion of CD4+CD25+FoxP3+ T Regulatory Cells Based on Synergy between IL-2 and 4-1BB Signaling
J. Immunol., December 1, 2007; 179(11): 7295 - 7304.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Giroux, E. Yurchenko, J. St.-Pierre, C. A. Piccirillo, and C. Perreault
T Regulatory Cells Control Numbers of NK Cells and CD8{alpha}+ Immature Dendritic Cells in the Lymph Node Paracortex
J. Immunol., October 1, 2007; 179(7): 4492 - 4502.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Oberle, N. Eberhardt, C. S. Falk, P. H. Krammer, and E. Suri-Payer
Rapid Suppression of Cytokine Transcription in Human CD4+CD25 T Cells by CD4+Foxp3+ Regulatory T Cells: Independence of IL-2 Consumption, TGF-beta, and Various Inhibitors of TCR Signaling
J. Immunol., September 15, 2007; 179(6): 3578 - 3587.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips
DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma
J. Immunol., September 15, 2007; 179(6): 3763 - 3771.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Wei, I. Kryczek, R. P. Edwards, L. Zou, W. Szeliga, M. Banerjee, M. Cost, P. Cheng, A. Chang, B. Redman, et al.
Interleukin-2 Administration Alters the CD4+FOXP3+ T-Cell Pool and Tumor Trafficking in Patients with Ovarian Carcinoma
Cancer Res., August 1, 2007; 67(15): 7487 - 7494.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
T. Bopp, C. Becker, M. Klein, S. Klein-Hessling, A. Palmetshofer, E. Serfling, V. Heib, M. Becker, J. Kubach, S. Schmitt, et al.
Cyclic adenosine monophosphate is a key component of regulatory T cell mediated suppression
J. Exp. Med., June 11, 2007; 204(6): 1303 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. G. Chan, M. Mayer, E. M. Davis, S. A. Halperin, T.-J. Lin, and S. F. Lee
Role of D-Alanylation of Streptococcus gordonii Lipoteichoic Acid in Innate and Adaptive Immunity
Infect. Immun., June 1, 2007; 75(6): 3033 - 3042.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. Yates, F. Rovis, P. Mitchell, B. Afzali, J.-S Tsang, M. Garin, R. Lechler, G. Lombardi, and O. Garden
The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro
Int. Immunol., June 1, 2007; 19(6): 785 - 799.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Xu, A. Kitani, I. Fuss, and W. Strober
Cutting Edge: Regulatory T Cells Induce CD4+CD25-Foxp3- T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-beta
J. Immunol., June 1, 2007; 178(11): 6725 - 6729.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Kryczek, S. Wei, L. Zou, S. Altuwaijri, W. Szeliga, J. Kolls, A. Chang, and W. Zou
Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment
J. Immunol., June 1, 2007; 178(11): 6730 - 6733.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. Andersson, I. Stefanova, G. L. Stephens, and E. M. Shevach
CD4+CD25+ regulatory T cells are activated in vivo by recognition of self
Int. Immunol., April 1, 2007; 19(4): 557 - 566.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. S. Davidson, R. J. DiPaolo, J. Andersson, and E. M. Shevach
Cutting Edge: IL-2 Is Essential for TGF-beta-Mediated Induction of Foxp3+ T Regulatory Cells
J. Immunol., April 1, 2007; 178(7): 4022 - 4026.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. L. Bayer, A. Yu, and T. R. Malek
Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells
J. Immunol., April 1, 2007; 178(7): 4062 - 4071.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Dai, B. Liu, S. M. Ngoi, S. Sun, A. T. Vella, and Z. Li
TLR4 Hyperresponsiveness via Cell Surface Expression of Heat Shock Protein gp96 Potentiates Suppressive Function of Regulatory T Cells
J. Immunol., March 1, 2007; 178(5): 3219 - 3225.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
F. Marangoni, S. Trifari, S. Scaramuzza, C. Panaroni, S. Martino, L. D. Notarangelo, Z. Baz, A. Metin, F. Cattaneo, A. Villa, et al.
WASP regulates suppressor activity of human and murine CD4+CD25+FOXP3+ natural regulatory T cells
J. Exp. Med., February 19, 2007; 204(2): 369 - 380.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. H. Maillard, V. Cotta-de-Almeida, F. Takeshima, D. D. Nguyen, P. Michetti, C. Nagler, A. K. Bhan, and S. B. Snapper
The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells
J. Exp. Med., February 19, 2007; 204(2): 381 - 391.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. G. Zheng, J. Wang, P. Wang, J. D. Gray, and D. A. Horwitz
IL-2 Is Essential for TGF-beta to Convert Naive CD4+CD25- Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells
J. Immunol., February 15, 2007; 178(4): 2018 - 2027.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. Bodor, Z. Fehervari, B. Diamond, and S. Sakaguchi
Regulatory T cell-mediated suppression: potential role of ICER
J. Leukoc. Biol., January 1, 2007; 81(1): 161 - 167.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Carrier, J. Yuan, V. K. Kuchroo, and H. L. Weiner
Th3 Cells in Peripheral Tolerance. II. TGF-beta-Transgenic Th3 Cells Rescue IL-2-Deficient Mice from Autoimmunity
J. Immunol., January 1, 2007; 178(1): 172 - 178.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Burchill, J. Yang, C. Vogtenhuber, B. R. Blazar, and M. A. Farrar
IL-2 Receptor beta-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells
J. Immunol., January 1, 2007; 178(1): 280 - 290.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Hoffmann, R. Eder, T. J. Boeld, K. Doser, B. Piseshka, R. Andreesen, and M. Edinger
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
Blood, December 15, 2006; 108(13): 4260 - 4267.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. L. Sukiennicki and D. J. Fowell
Distinct Molecular Program Imposed on CD4+ T Cell Targets by CD4+CD25+ Regulatory T Cells
J. Immunol., November 15, 2006; 177(10): 6952 - 6961.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. A. Cavassani, A. P. Campanelli, A. P. Moreira, J. O. Vancim, L. H. Vitali, R. C. Mamede, R. Martinez, and J. S. Silva
Systemic and Local Characterization of Regulatory T Cells in a Chronic Fungal Infection in Humans
J. Immunol., November 1, 2006; 177(9): 5811 - 5818.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Yu and T. R. Malek
Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells
J. Immunol., October 15, 2006; 177(8): 5115 - 5121.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Grimbert, S. Bouguermouh, N. Baba, T. Nakajima, Z. Allakhverdi, D. Braun, H. Saito, M. Rubio, G. Delespesse, and M. Sarfati
Thrombospondin/CD47 Interaction: A Pathway to Generate Regulatory T Cells from Human CD4+CD25- T Cells in Response to Inflammation
J. Immunol., September 15, 2006; 177(6): 3534 - 3541.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Toda and C. A. Piccirillo
Development and function of naturally occurring CD4+CD25+ regulatory T cells
J. Leukoc. Biol., September 1, 2006; 80(3): 458 - 470.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Zorn, E. A. Nelson, M. Mohseni, F. Porcheray, H. Kim, D. Litsa, R. Bellucci, E. Raderschall, C. Canning, R. J. Soiffer, et al.
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
Blood, September 1, 2006; 108(5): 1571 - 1579.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Rezvani, S. Mielke, M. Ahmadzadeh, Y. Kilical, B. N. Savani, J. Zeilah, K. Keyvanfar, A. Montero, N. Hensel, R. Kurlander, et al.
High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT
Blood, August 15, 2006; 108(4): 1291 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Wei, I. Kryczek, and W. Zou
Regulatory T-cell compartmentalization and trafficking
Blood, July 15, 2006; 108(2): 426 - 431.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Zeiser, V. H. Nguyen, A. Beilhack, M. Buess, S. Schulz, J. Baker, C. H. Contag, and R. S. Negrin
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
Blood, July 1, 2006; 108(1): 390 - 399.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Beyer, M. Kochanek, T. Giese, E. Endl, M. R. Weihrauch, P. A. Knolle, S. Classen, and J. L. Schultze
In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma
Blood, May 15, 2006; 107(10): 3940 - 3949.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D.-M. Zhao, A. M. Thornton, R. J. DiPaolo, and E. M. Shevach
Activated CD4+CD25+ T cells selectively kill B lymphocytes
Blood, May 15, 2006; 107(10): 3925 - 3932.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Liu, M. Komai-Koma, D. Xu, and F. Y. Liew
Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells
PNAS, May 2, 2006; 103(18): 7048 - 7053.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
R Duchmann and M Zeitz
T regulatory cell suppression of colitis: the role of TGF-{beta}
Gut, May 1, 2006; 55(5): 604 - 606.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
P. A. Antony, C. M. Paulos, M. Ahmadzadeh, A. Akpinarli, D. C. Palmer, N. Sato, A. Kaiser, C. Heinrichs, C. A. Klebanoff, Y. Tagaya, et al.
Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo
J. Immunol., May 1, 2006; 176(9): 5255 - 5266.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Pace, S. Rizzo, C. Palombi, F. Brombacher, and G. Doria
Cutting Edge: IL-4-Induced Protection of CD4+CD25- Th Cells from CD4+CD25+ Regulatory T Cell-Mediated Suppression
J. Immunol., April 1, 2006; 176(7): 3900 - 3904.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Ebata, Y. Shimizu, Y. Nakayama, M. Minemura, J. Murakami, T. Kato, S. Yasumura, T. Takahara, T. Sugiyama, and S. Saito
Immature NK Cells Suppress Dendritic Cell Functions during the Development of Leukemia in a Mouse Model
J. Immunol., April 1, 2006; 176(7): 4113 - 4124.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. P. Kohm, J. S. McMahon, J. R. Podojil, W. S. Begolka, M. DeGutes, D. J. Kasprowicz, S. F. Ziegler, and S. D. Miller
Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells
J. Immunol., March 15, 2006; 176(6): 3301 - 3305.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Lyddane, B. U. Gajewska, E. Santos, P. D. King, G. C. Furtado, and M. Sadelain
Cutting Edge: CD28 Controls Dominant Regulatory T Cell Activity during Active Immunization
J. Immunol., March 15, 2006; 176(6): 3306 - 3310.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Ahmadzadeh and S. A. Rosenberg
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients
Blood, March 15, 2006; 107(6): 2409 - 2414.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
I. P. Lewkowich, N. S. Herman, K. W. Schleifer, M. P. Dance, B. L. Chen, K. M. Dienger, A. A. Sproles, J. S. Shah, J. Kohl, Y. Belkaid, et al.
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
J. Exp. Med., December 5, 2005; 202(11): 1549 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. J. DiPaolo, D. D. Glass, K. E. Bijwaard, and E. M. Shevach
CD4+CD25+ T Cells Prevent the Development of Organ-Specific Autoimmune Disease by Inhibiting the Differentiation of Autoreactive Effector T Cells
J. Immunol., December 1, 2005; 175(11): 7135 - 7142.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. K. Sojka, A. Hughson, T. L. Sukiennicki, and D. J. Fowell
Early Kinetic Window of Target T Cell Susceptibility to CD25+ Regulatory T Cell Activity
J. Immunol., December 1, 2005; 175(11): 7274 - 7280.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Brinster and E. M. Shevach
Bone Marrow-Derived Dendritic Cells Reverse the Anergic State of CD4+CD25+ T Cells without Reversing Their Suppressive Function
J. Immunol., December 1, 2005; 175(11): 7332 - 7340.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. S. Krupnick, A. E. Gelman, W. Barchet, S. Richardson, F. H. Kreisel, L. A. Turka, M. Colonna, G. A. Patterson, and D. Kreisel
Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells
J. Immunol., November 15, 2005; 175(10): 6265 - 6270.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Li, W. R. Godfrey, S. B. Porter, Y. Ge, C. H. June, B. R. Blazar, and V. A. Boussiotis
CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy
Blood, November 1, 2005; 106(9): 3068 - 3073.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L.-X. Wang, S. Shu, and G. E. Plautz
Host Lymphodepletion Augments T Cell Adoptive Immunotherapy through Enhanced Intratumoral Proliferation of Effector Cells
Cancer Res., October 15, 2005; 65(20): 9547 - 9554.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
N. Beyersdorf, S. Gaupp, K. Balbach, J. Schmidt, K. V. Toyka, C.-H. Lin, T. Hanke, T. Hunig, T. Kerkau, and R. Gold
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
J. Exp. Med., August 1, 2005; 202(3): 445 - 455.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. L. King and B. M. Segal
Cutting Edge: IL-12 Induces CD4+CD25- T Cell Activation in the Presence of T Regulatory Cells
J. Immunol., July 15, 2005; 175(2): 641 - 645.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Bienvenu, B. Martin, C. Auffray, C. Cordier, C. Becourt, and B. Lucas
Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity
J. Immunol., July 1, 2005; 175(1): 246 - 253.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. M. Freeman and H. K. Ziegler
Simultaneous Th1-Type Cytokine Expression Is a Signature of Peritoneal CD4+ Lymphocytes Responding to Infection with Listeria monocytogenes
J. Immunol., July 1, 2005; 175(1): 394 - 403.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
C. R. Ruprecht, M. Gattorno, F. Ferlito, A. Gregorio, A. Martini, A. Lanzavecchia, and F. Sallusto
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
J. Exp. Med., June 6, 2005; 201(11): 1793 - 1803.
[Abstract] [Full Text] [PDF]

Home page