The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Abel, S.
Right arrow Articles by Ludwig, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abel, S.
Right arrow Articles by Ludwig, A.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*OMIM
*UniGene
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*12-O-TETRADECANOYLPHORBOL-13-ACETATE
The Journal of Immunology, 2004, 172: 6362-6372.
Copyright © 2004 by The American Association of Immunologists

The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-{gamma} and TNF-{alpha} and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10 1

Soeren Abel2,*, Christian Hundhausen2,*, Rolf Mentlein{dagger}, Alexander Schulte*, Theo A. Berkhout3,{ddagger}, Neil Broadway3,{ddagger}, Dieter Hartmann§, Radek Sedlacek*, Sebastian Dietrich*, Barbara Muetze*, Bjoern Schuster*, Karl-Josef Kallen*, Paul Saftig*, Stefan Rose-John* and Andreas Ludwig4,*

Institutes for * Biochemistry and {dagger} Anatomy, Christian-Albrechts-University, Kiel, Germany; {ddagger} Departments of Atherosclerosis and Gene Expression and Protein Chemistry, GlaxoSmithKline, Stevenage, United Kingdom; and § Center for Human Genetics, Leuven and Flanders Interuniversity, Leuven, Belgium

The novel CXC-chemokine ligand 16 (CXCL16) functions as transmembrane adhesion molecule on the surface of APCs and as a soluble chemoattractant for activated T cells. In this study, we elucidate the mechanism responsible for the conversion of the transmembrane molecule into a soluble chemokine and provide evidence for the expression and shedding of CXCL16 by fibroblasts and vascular cells. By transfection of human and murine CXCL16 in different cell lines, we show that soluble CXCL16 is constitutively generated by proteolytic cleavage of transmembrane CXCL16 resulting in reduced surface expression of the transmembrane molecule. Inhibition experiments with selective hydroxamate inhibitors against the disintegrin-like metalloproteinases a disintegrin and metalloproteinase domain (ADAM)10 and ADAM17 suggest that ADAM10, but not ADAM17, is involved in constitutive CXCL16 cleavage. In addition, the constitutive cleavage of transfected human CXCL16 was markedly reduced in embryonic fibroblasts generated from ADAM10-deficient mice. By induction of murine CXCL16 in ADAM10-deficient fibroblasts with IFN-{gamma} and TNF-{alpha}, we show that endogenous ADAM10 is indeed involved in the release of endogenous CXCL16. Finally, the shedding of endogenous CXCL16 could be reconstituted by retransfection of ADAM10-deficient cells with ADAM10. Analyzing the expression and release of CXCXL16 by cultured vascular cells, we found that IFN-{gamma} and TNF-{alpha} synergize to induce CXCL16 mRNA. The constitutive shedding of CXCL16 from the endothelial cell surface is blocked by inhibitors of ADAM10 and is independent of additional inhibition of ADAM17. Hence, during inflammation in the vasculature, ADAM10 may act as a CXCL16 sheddase and thereby finely control the expression and function of CXCL16 in the inflamed tissue.




This article has been cited by other articles:


Home page
J. Immunol.Home page
S. Matsumura, B. Wang, N. Kawashima, S. Braunstein, M. Badura, T. O. Cameron, J. S. Babb, R. J. Schneider, S. C. Formenti, M. L. Dustin, et al.
Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells
J. Immunol., September 1, 2008; 181(5): 3099 - 3107.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
R. M. McLoughlin, J. C. Lee, D. L. Kasper, and A. O. Tzianabos
IFN-{gamma} Regulated Chemokine Production Determines the Outcome of Staphylococcus aureus Infection
J. Immunol., July 15, 2008; 181(2): 1323 - 1332.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
C. Smith, B. Halvorsen, K. Otterdal, T. Waehre, A. Yndestad, B. Fevang, W. J. Sandberg, U. M. Breland, S. S. Froland, E. Oie, et al.
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc Res, July 1, 2008; 79(1): 195 - 203.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. S. Hebert, K. Horre, L. Nicolai, A. S. Papadopoulou, W. Mandemakers, A. N. Silahtaroglu, S. Kauppinen, A. Delacourte, and B. De Strooper
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/{beta}-secretase expression
PNAS, April 29, 2008; 105(17): 6415 - 6420.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
Y. Lu, J. Wang, Y. Xu, A. E. Koch, Z. Cai, X. Chen, D. L. Galson, R. S. Taichman, and J. Zhang
CXCL16 Functions as a Novel Chemotactic Factor for Prostate Cancer Cells In vitro
Mol. Cancer Res., April 1, 2008; 6(4): 546 - 554.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Y. Huang, X.-Y. Zhu, M.-R. Du, and D.-J. Li
Human Trophoblasts Recruited T Lymphocytes and Monocytes into Decidua by Secretion of Chemokine CXCL16 and Interaction with CXCR6 in the First-Trimester Pregnancy
J. Immunol., February 15, 2008; 180(4): 2367 - 2375.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
E. Galkina, B. L. Harry, A. Ludwig, E. A. Liehn, J. M. Sanders, A. Bruce, C. Weber, and K. Ley
CXCR6 Promotes Atherosclerosis by Supporting T-Cell Homing, Interferon-{gamma} Production, and Macrophage Accumulation in the Aortic Wall
Circulation, October 16, 2007; 116(16): 1801 - 1811.
[Abstract] [Full Text] [PDF]


Home page
Ann Rheum DisHome page
A. W T van Lieshout, J. Fransen, M. Flendrie, A. M M Eijsbouts, F. H J van den Hoogen, P. L C M van Riel, and T. R D J Radstake
Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis
Ann Rheum Dis, October 1, 2007; 66(10): 1334 - 1338.
[Abstract] [Full Text] [PDF]


Home page
Int ImmunolHome page
M. Tohyama, K. Sayama, H. Komatsuzawa, Y. Hanakawa, Y. Shirakata, X. Dai, L. Yang, S. Tokumaru, H. Nagai, S. Hirakawa, et al.
CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes
Int. Immunol., September 1, 2007; 19(9): 1095 - 1102.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
D. M. Okamura, J. M. Lopez-Guisa, K. Koelsch, S. Collins, and A. A. Eddy
Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F575 - F585.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
C. Hundhausen, A. Schulte, B. Schulz, M. G. Andrzejewski, N. Schwarz, P. von Hundelshausen, U. Winter, K. Paliga, K. Reiss, P. Saftig, et al.
Regulated Shedding of Transmembrane Chemokines by the Disintegrin and Metalloproteinase 10 Facilitates Detachment of Adherent Leukocytes
J. Immunol., June 15, 2007; 178(12): 8064 - 8072.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
X. Ju, S. Katiyar, C. Wang, M. Liu, X. Jiao, S. Li, J. Zhou, J. Turner, M. P. Lisanti, R. G. Russell, et al.
Akt1 governs breast cancer progression in vivo
PNAS, May 1, 2007; 104(18): 7438 - 7443.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
G. E. Garcia, L. D. Truong, P. Li, P. Zhang, R. J. Johnson, C. B. Wilson, and L. Feng
Inhibition of CXCL16 Attenuates Inflammatory and Progressive Phases of Anti-Glomerular Basement Membrane Antibody-Associated Glomerulonephritis
Am. J. Pathol., May 1, 2007; 170(5): 1485 - 1496.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
M. Lehrke, S. C. Millington, M. Lefterova, R. G. Cumaranatunge, P. Szapary, R. Wilensky, D. J. Rader, M. A. Lazar, and M. P. Reilly
CXCL16 Is a Marker of Inflammation, Atherosclerosis, and Acute Coronary Syndromes in Humans
J. Am. Coll. Cardiol., January 30, 2007; 49(4): 442 - 449.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
H. J. J. van der Vliet, M. G. A. van Vonderen, J. W. Molling, H. J. Bontkes, M. Reijm, P. Reiss, M. A. van Agtmael, S. A. Danner, A. J. M. van den Eertwegh, B. M. E. von Blomberg, et al.
Cutting Edge: Rapid Recovery of NKT Cells upon Institution of Highly Active Antiretroviral Therapy for HIV-1 Infection
J. Immunol., November 1, 2006; 177(9): 5775 - 5778.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
A. M. Aslanian and I. F. Charo
Targeted Disruption of the Scavenger Receptor and Chemokine CXCL16 Accelerates Atherosclerosis
Circulation, August 8, 2006; 114(6): 583 - 590.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
S. Rose-John, J. Scheller, G. Elson, and S. A. Jones
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
J. Leukoc. Biol., August 1, 2006; 80(2): 227 - 236.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. Gursel, I. Gursel, H. S. Mostowski, and D. M. Klinman
CXCL16 Influences the Nature and Specificity of CpG-Induced Immune Activation
J. Immunol., August 1, 2006; 177(3): 1575 - 1580.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
H. Ohtsu, P. J. Dempsey, and S. Eguchi
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
Am J Physiol Cell Physiol, July 1, 2006; 291(1): C1 - C10.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
K. J. Garton, P. J. Gough, and E. W. Raines
Emerging roles for ectodomain shedding in the regulation of inflammatory responses
J. Leukoc. Biol., June 1, 2006; 79(6): 1105 - 1116.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Z. Mikhak, C. M. Fleming, B. D. Medoff, S. Y. Thomas, A. M. Tager, G. S. Campanella, and A. D. Luster
STAT1 in Peripheral Tissue Differentially Regulates Homing of Antigen-Specific Th1 and Th2 Cells.
J. Immunol., April 15, 2006; 176(8): 4959 - 4967.
[Abstract] [Full Text] [PDF]


Home page
Hum ReprodHome page
Y. Huang, X.-Y. Zhu, M.-R. Du, X. Wu, M.-Y. Wang, and D.-J. Li
Chemokine CXCL16, a scavenger receptor, induces proliferation and invasion of first-trimester human trophoblast cells in an autocrine manner
Hum. Reprod., April 1, 2006; 21(4): 1083 - 1091.
[Abstract] [Full Text] [PDF]


Home page
Int ImmunolHome page
T. Hara, T. Katakai, J.-H. Lee, Y. Nambu, N. Nakajima-Nagata, H. Gonda, M. Sugai, and A. Shimizu
A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion
Int. Immunol., February 1, 2006; 18(2): 301 - 311.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. Hase, T. Murakami, H. Takatsu, T. Shimaoka, M. Iimura, K. Hamura, K. Kawano, S. Ohshima, R. Chihara, K. Itoh, et al.
The Membrane-Bound Chemokine CXCL16 Expressed on Follicle-Associated Epithelium and M Cells Mediates Lympho-Epithelial Interaction in GALT
J. Immunol., January 1, 2006; 176(1): 43 - 51.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
V. Budagian, E. Bulanova, Z. Orinska, E. Duitman, K. Brandt, A. Ludwig, D. Hartmann, G. Lemke, P. Saftig, and S. Bulfone-Paus
Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum
Mol. Cell. Biol., November 1, 2005; 25(21): 9324 - 9339.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
T. Maretzky, M. Schulte, A. Ludwig, S. Rose-John, C. Blobel, D. Hartmann, P. Altevogt, P. Saftig, and K. Reiss
L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/{gamma}-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth
Mol. Cell. Biol., October 15, 2005; 25(20): 9040 - 9053.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
B. Chandrasekar, S. Mummidi, A. J. Valente, D. N. Patel, S. R. Bailey, G. L. Freeman, M. Hatano, T. Tokuhisa, and L. E. Jensen
The Pro-atherogenic Cytokine Interleukin-18 Induces CXCL16 Expression in Rat Aortic Smooth Muscle Cells via MyD88, Interleukin-1 Receptor-associated Kinase, Tumor Necrosis Factor Receptor-associated Factor 6, c-Src, Phosphatidylinositol 3-Kinase, Akt, c-Jun N-terminal Kinase, and Activator Protein-1 Signaling
J. Biol. Chem., July 15, 2005; 280(28): 26263 - 26277.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
S. Tabata, N. Kadowaki, T. Kitawaki, T. Shimaoka, S. Yonehara, O. Yoshie, and T. Uchiyama
Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4+ T cells
J. Leukoc. Biol., May 1, 2005; 77(5): 777 - 786.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Rabie, A. Strehl, A. Ludwig, and B. Nieswandt
Evidence for a Role of ADAM17 (TACE) in the Regulation of Platelet Glycoprotein V
J. Biol. Chem., April 15, 2005; 280(15): 14462 - 14468.
[Abstract] [Full Text] [PDF]


Home page
Eur J EndocrinolHome page
G Aust, M Kamprad, P Lamesch, and E Schmucking
CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves' disease (GD)
Eur. J. Endocrinol., April 1, 2005; 152(4): 635 - 643.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
S. J. Levine
Mechanisms of Soluble Cytokine Receptor Generation
J. Immunol., November 1, 2004; 173(9): 5343 - 5348.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
C. Weber, A. Schober, and A. Zernecke
Chemokines: Key Regulators of Mononuclear Cell Recruitment in Atherosclerotic Vascular Disease
Arterioscler. Thromb. Vasc. Biol., November 1, 2004; 24(11): 1997 - 2008.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
V. Budagian, E. Bulanova, Z. Orinska, A. Ludwig, S. Rose-John, P. Saftig, E. C. Borden, and S. Bulfone-Paus
Natural Soluble Interleukin-15R{alpha} Is Generated by Cleavage That Involves the Tumor Necrosis Factor-{alpha}-converting Enzyme (TACE/ADAM17)
J. Biol. Chem., September 24, 2004; 279(39): 40368 - 40375.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.