| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cytos Biotechnology, AG, Zürich, Switzerland
The MHC class I pathway is usually fueled by endogenous Ags, while exogenous Ags reach the MHC class II pathway. Although exogenous epitopes may also enter the MHC class I pathway, quantification of the efficiency of the process has remained a difficult task. In an attempt of such a quantification, we directly compared the amount of exogenous virus-like particles required for induction of cytotoxic T cell responses by cross-priming with the amount of virus-like particles required for induction of Th cell responses by the conventional route of MHC class II loading as an internal standard. Surprisingly, we found that cross-presentation of peptides derived from exogenous Ags on MHC class I molecules is of only marginally lower efficiency (
1- to 10-fold) than the classical MHC class II pathway in vitro and in vivo. Thus, Ag quantities required for cross-presentation and cross-priming are similar to those required for fueling the MHC class II pathway.
This article has been cited by other articles:
|
|
 |
|
  S. A. Keller, C. E. von Allmen, H. J. Hinton, M. Bauer, S. Muntwiler, K. Dietmeier, P. Saudan, and M. F. Bachmann Follicular and Marginal Zone B Cells Fail to Cross-Present MHC Class I-Restricted Epitopes Derived from Viral Particles J. Immunol., May 15, 2009; 182(10): 6261 - 6266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Coppieters, A. M. Barral, A. Juedes, T. Wolfe, E. Rodrigo, C. Thery, S. Amigorena, and M. G. von Herrath No Significant CTL Cross-Priming by Dendritic Cell-Derived Exosomes during Murine Lymphocytic Choriomeningitis Virus Infection J. Immunol., February 15, 2009; 182(4): 2213 - 2220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kuffova, M. Netukova, L. Duncan, A. Porter, B. Stockinger, and J. V. Forrester Cross Presentation of Antigen on MHC Class II via the Draining Lymph Node after Corneal Transplantation in Mice J. Immunol., February 1, 2008; 180(3): 1353 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Leclerc, D. Beauseigle, J. Denis, H. Morin, C. Pare, A. Lamarre, and R. Lapointe Proteasome-Independent Major Histocompatibility Complex Class I Cross-Presentation Mediated by Papaya Mosaic Virus-Like Particles Leads to Expansion of Specific Human T Cells J. Virol., February 1, 2007; 81(3): 1319 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cooper and Y. Shaul Clathrin-mediated Endocytosis and Lysosomal Cleavage of Hepatitis B Virus Capsid-like Core Particles J. Biol. Chem., June 16, 2006; 281(24): 16563 - 16569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nembrini, B. Abel, M. Kopf, and B. J. Marsland Strong TCR Signaling, TLR Ligands, and Cytokine Redundancies Ensure Robust Development of Type 1 Effector T Cells. J. Immunol., June 15, 2006; 176(12): 7180 - 7188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Mwangi, W. C. Brown, G. A. Splitter, Y. Zhuang, K. Kegerreis, and G. H. Palmer Enhancement of antigen acquisition by dendritic cells and MHC class II-restricted epitope presentation to CD4+ T cells using VP22 DNA vaccine vectors that promote intercellular spreading following initial transfection J. Leukoc. Biol., August 1, 2005; 78(2): 401 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ruedl, K. Schwarz, A. Jegerlehner, T. Storni, V. Manolova, and M. F. Bachmann Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies J. Virol., January 15, 2005; 79(2): 717 - 724. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
