| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Advanced Medical Discovery Institute, Ontario Cancer Institute, Toronto, Ontario, Canada;
Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada; and
University Hospital Zurich, Department of Pathology, Zurich, Switzerland
CD28 plays crucial costimulatory roles in T cell proliferation, cytokine production, and germinal center response. Mice that are deficient in the inducible costimulator (ICOS) also have defects in cytokine production and germinal center response. Because the full induction of ICOS in activated T cells depends on CD28 signal, the T cell costimulatory capacity of ICOS in the absence of CD28 has remained unclear. We have clarified this issue by comparing humoral immune responses in wild-type, CD28 knockout (CD28 KO), and CD28-ICOS double-knockout (DKO) mice. DKO mice had profound defects in Ab responses against environmental Ags, T-dependent protein Ags, and vesicular stomatitis virus that extended far beyond those observed in CD28 KO mice. However, DKO mice mounted normal Ab responses against a T-independent Ag, indicating that B cell function itself was normal. Restimulated CD4+ DKO T cells that had been primed in vivo showed decreased proliferation and reduced IL-4 and IL-10 production compared with restimulated CD4+ T cells from CD28 KO mice. Thus, in the absence of CD28, ICOS assumes the major T cell costimulatory role for humoral immune responses. Importantly, CD28-mediated ICOS up-regulation is not essential for ICOS function in vivo.
This article has been cited by other articles:
|
|
 |
|
  H. Lu, B. L. F. Kaplan, T. Ngaotepprutaram, and N. E. Kaminski Suppression of T cell costimulator ICOS by {Delta}9-tetrahydrocannabinol J. Leukoc. Biol., February 1, 2009; 85(2): 322 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Guo, C. Iclozan, W.-K. Suh, C. Anasetti, and X.-Z. Yu CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells J. Immunol., August 15, 2008; 181(4): 2285 - 2291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bergqvist, E. Gardby, A. Stensson, M. Bemark, and N. Y. Lycke Gut IgA Class Switch Recombination in the Absence of CD40 Does Not Occur in the Lamina Propria and Is Independent of Germinal Centers J. Immunol., December 1, 2006; 177(11): 7772 - 7783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H.-M. Tan, S.-C. Wong, and K.-P. Lam Regulation of Mouse Inducible Costimulator (ICOS) Expression by Fyn-NFATc2 and ERK Signaling in T Cells J. Biol. Chem., September 29, 2006; 281(39): 28666 - 28678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-K. Suh, S. Wang, G. S. Duncan, Y. Miyazaki, E. Cates, T. Walker, B. U. Gajewska, E. Deenick, W. Dawicki, H. Okada, et al. Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice. Mol. Cell. Biol., September 1, 2006; 26(17): 6403 - 6411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vidric, W.-K. Suh, U. Dianzani, T. W. Mak, and T. H. Watts Cooperation between 4-1BB and ICOS in the Immune Response to Influenza Virus Revealed by Studies of CD28/ICOS-Deficient Mice J. Immunol., December 1, 2005; 175(11): 7288 - 7296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Weiler and J. L. Bankers-Fulbright Common Variable Immunodeficiency: Test Indications and Interpretations Mayo Clin. Proc., September 1, 2005; 80(9): 1187 - 1200. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Loke, X. Zang, L. Hsuan, R. Waitz, R. M. Locksley, J. E. Allen, and J. P. Allison Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection PNAS, July 12, 2005; 102(28): 9872 - 9877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. A. T. van Berkel, E. H. R. Schrijver, F. M. A. Hofhuis, A. H. Sharpe, A. J. Coyle, C. P. Broeren, K. Tesselaar, and M. A. Oosterwegel ICOS Contributes to T Cell Expansion in CTLA-4 Deficient Mice J. Immunol., July 1, 2005; 175(1): 182 - 188. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
