HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bryson, J. S. Articles by Kaplan, A. M. Search for Related Content PubMed PubMed Citation Articles by Bryson, J. S. Articles by Kaplan, A. M.

CD4⁺ T Cells Mediate Murine Syngeneic Graft-versus-Host Disease-Associated Colitis¹

J. Scott Bryson^2,*,,¶, Lining Zhang^,||, Sarah W. Goes, C. Darrell Jennings^,¶, Betty E. Caywood^*, Sonia L. Carlson and Alan M. Kaplan^,¶

Departments of ^* Internal Medicine, Microbiology, Immunology, and Molecular Biology, Pathology, and Anatomy and Neurobiology, and ^¶ Markey Cancer Center, Chandler Medical Center, University of Kentucky, Lexington, KY 40536; and ^|| Immunology Institute of Medical College, Shandong University, Shandong, People’s Republic of China

Syngeneic graft-vs-host disease (SGVHD) develops following lethal irradiation, reconstitution with syngeneic bone marrow, and treatment with a 21-day course of the immunosuppressive agent cyclosporin A (CsA). Following cessation of CsA, this inducible disease is characterized by weight loss, diarrhea, and development of inflammation in the colon and liver. Although nonspecific effector cells and Th1 cytokines have been shown to participate in disease induction, the role of T cells has not been fully elucidated. Initial studies demonstrated significant increases in CD4⁺ T cells, but not other T cell populations in the colons of diseased animals relative to transplant control animals. To demonstrate a functional linkage between increases in colonic CD4⁺ T cells and disease induction, in vivo T cell depletion studies were performed. Beginning on the day of bone marrow transplantation, groups of control and CsA-treated animals were treated with mAb against either CD4 or CD8 for 21 days. Treatment with anti-CD4, but not anti-CD8, eliminated clinical symptoms and colon pathology. Interestingly, neither anti-CD4 nor anti-CD8 therapy affected the development of liver pathology associated with SGVHD. These findings demonstrated that CD4⁺ T cells initiate development of the intestinal inflammation associated with murine SGVHD.

This article has been cited by other articles:

				J. S. Bryson, C. D. Jennings, J. A. Brandon, J. Perez, B. E. Caywood, and A. M. Kaplan Adoptive transfer of murine syngeneic graft-vs.-host disease by CD4+ T cells J. Leukoc. Biol., December 1, 2007; 82(6): 1393 - 1400. [Abstract] [Full Text] [PDF]

				J. Chen, F. M. Ellison, M. A. Eckhaus, A. L. Smith, K. Keyvanfar, R. T. Calado, and N. S. Young Minor Antigen H60-Mediated Aplastic Anemia Is Ameliorated by Immunosuppression and the Infusion of Regulatory T Cells J. Immunol., April 1, 2007; 178(7): 4159 - 4168. [Abstract] [Full Text] [PDF]