The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chang, J.
Right arrow Articles by Braciale, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chang, J.
Right arrow Articles by Braciale, T. J.
The Journal of Immunology, 2004, 172: 503-508.
Copyright © 2004 by The American Association of Immunologists

Improved Effector Activity and Memory CD8 T Cell Development by IL-2 Expression during Experimental Respiratory Syncytial Virus Infection 1

Jun Chang2,*, So Young Choi*, Hyun Tak Jin*, Young Chul Sung* and Thomas J. Braciale{dagger}

* Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea; and {dagger} Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908

Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. Studies of mice suggest that RSV suppresses the effector activity of CD8 T cells and the development of pulmonary CD8 T cell memory, in which the impaired effector activity could be recovered by in vitro IL-2 treatment. To investigate the effect of in vivo IL-2 expression on RSV immunity, mice were infected with RSV followed by administration of replication-defective adenovirus expressing IL-2. The effector activity of RSV M2-specific CD8 T cells and the development of CD8 T cell memory in the lung was significantly increased by IL-2 expression. Furthermore, the Ab responses against RSV were augmented by IL-2. Interestingly, weight loss and illness caused by RSV challenge were substantially reduced by IL-2 priming, suggesting that the pathogenesis of RSV-related disease could be prevented by IL-2-mediated enhancement of beneficial immune responses. Thus, our results show that IL-2 has potential to be used as a vaccine adjuvant against RSV infection.




This article has been cited by other articles:


Home page
J. Immunol.Home page
D. K. Meyerholz, M. Edsen-Moore, J. McGill, R. A. Coleman, R. T. Cook, and K. L. Legge
Chronic Alcohol Consumption Increases the Severity of Murine Influenza Virus Infections
J. Immunol., July 1, 2008; 181(1): 641 - 648.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. R. Olson and S. M. Varga
CD8 T Cells Inhibit Respiratory Syncytial Virus (RSV) Vaccine-Enhanced Disease
J. Immunol., October 15, 2007; 179(8): 5415 - 5424.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. Boxus, M. Tignon, S. Roels, J.-F. Toussaint, K. Walravens, M.-A. Benoit, P. Coppe, J.-J. Letesson, C. Letellier, and P. Kerkhofs
DNA Immunization with Plasmids Encoding Fusion and Nucleocapsid Proteins of Bovine Respiratory Syncytial Virus Induces a Strong Cell-Mediated Immunity and Protects Calves against Challenge
J. Virol., July 1, 2007; 81(13): 6879 - 6889.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
N. W. Lukacs, M. L. Moore, B. D. Rudd, A. A. Berlin, R. D. Collins, S. J. Olson, S. B. Ho, and R. S. Peebles Jr
Differential Immune Responses and Pulmonary Pathophysiology Are Induced by Two Different Strains of Respiratory Syncytial Virus
Am. J. Pathol., September 1, 2006; 169(3): 977 - 986.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
J. Harcourt, R. Alvarez, L. P. Jones, C. Henderson, L. J. Anderson, and R. A. Tripp
Respiratory Syncytial Virus G Protein and G Protein CX3C Motif Adversely Affect CX3CR1+ T Cell Responses
J. Immunol., February 1, 2006; 176(3): 1600 - 1608.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
E. A. W. Claassen, P. A. A. van der Kant, Z. S. Rychnavska, G. M. van Bleek, A. J. Easton, and R. G. van der Most
Activation and Inactivation of Antiviral CD8 T Cell Responses during Murine Pneumovirus Infection
J. Immunol., November 15, 2005; 175(10): 6597 - 6604.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.