| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305; and
Departments of Medicine and Microbiology, University of Alabama, Birmingham, AL 35294
Tetraspanins have been hypothesized to facilitate the organization of functional multimolecular membrane complexes. In B cells the tetraspanin CD81 is a component of the CD19/CD21 complex. When coligated to the B cell Ag receptor (BCR), the CD19/CD21 complex significantly enhances BCR signaling in part by prolonging the association of the BCR with signaling-active lipid rafts. In this study CD81 is shown to associate with lipid rafts upon coligation of the BCR and the CD19/CD21 complex. Using B cells from CD81-deficient mice we demonstrate that in the absence of CD81, coligated BCR and CD19/CD21 complexes fail to partition into lipid rafts and enhance BCR signaling from rafts. Furthermore, a chimeric CD19 protein that associates only weakly if at all with CD81 fails to promote the association of coligated BCR with lipid rafts. The requirement for CD81 to promote lipid raft association may define a novel mechanism by which tetraspanins function as molecular facilitators of signaling receptors.
This article has been cited by other articles:
|
|
 |
|
  O. Barreiro, M. Zamai, M. Yanez-Mo, E. Tejera, P. Lopez-Romero, P. N. Monk, E. Gratton, V. R. Caiolfa, and F. Sanchez-Madrid Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms J. Cell Biol., November 3, 2008; 183(3): 527 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Serra, S. Nuti, S. Tavarini, C. Sammicheli, D. Rosa, G. Saletti, E. Soldaini, S. Abrignani, and A. Wack Coligation of the Hepatitis C Virus Receptor CD81 with CD28 Primes Naive T Lymphocytes to Acquire Type 2 Effector Function J. Immunol., July 1, 2008; 181(1): 174 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Wolf, M. G. Jobling, D. E. Saslowsky, E. Kern, K. R. Drake, A. K. Kenworthy, R. K. Holmes, and W. I. Lencer Attenuated Endocytosis and Toxicity of a Mutant Cholera Toxin with Decreased Ability To Cluster Ganglioside GM1 Molecules Infect. Immun., April 1, 2008; 76(4): 1476 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Griffiths, K. J. Heesom, and D. J. Anstee Normal prion protein trafficking in cultured human erythroblasts Blood, December 15, 2007; 110(13): 4518 - 4525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Heikens, T. M. Cao, C. Morita, S. L. DeHart, and S. Tsai Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis Blood, April 15, 2007; 109(8): 3244 - 3252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Kapadia, H. Barth, T. Baumert, J. A. McKeating, and F. V. Chisari Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I J. Virol., January 1, 2007; 81(1): 374 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Resh Palmitoylation of Ligands, Receptors, and Intracellular Signaling Molecules Sci. Signal., October 31, 2006; 2006(359): re14 - re14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bertaux and T. Dragic Different domains of CD81 mediate distinct stages of hepatitis C virus pseudoparticle entry. J. Virol., May 1, 2006; 80(10): 4940 - 4948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shoham, R. Rajapaksa, C.-C. Kuo, J. Haimovich, and S. Levy Building of the Tetraspanin Web: Distinct Structural Domains of CD81 Function in Different Cellular Compartments Mol. Cell. Biol., February 15, 2006; 26(4): 1373 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Levy and T. Shoham Protein-Protein Interactions in the Tetraspanin Web Physiology, August 1, 2005; 20(4): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shogomori, A. T. Hammond, A. G. Ostermeyer-Fay, D. J. Barr, G. W. Feigenson, E. London, and D. A. Brown Palmitoylation and Intracellular Domain Interactions Both Contribute to Raft Targeting of Linker for Activation of T Cells J. Biol. Chem., May 13, 2005; 280(19): 18931 - 18942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lyubchenko, J. Dal Porto, J. C. Cambier, and V. M. Holers Coligation of the B Cell Receptor with Complement Receptor Type 2 (CR2/CD21) Using Its Natural Ligand C3dg: Activation without Engagement of an Inhibitory Signaling Pathway J. Immunol., March 15, 2005; 174(6): 3264 - 3272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhou, L. Liu, M. Reddivari, and X. A. Zhang The Palmitoylation of Metastasis Suppressor KAI1/CD82 Is Important for Its Motility- and Invasiveness-Inhibitory Activity Cancer Res., October 15, 2004; 64(20): 7455 - 7463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Karacsonyi, R. Knorr, A. Fulbier, and R. Lindner Association of Major Histocompatibility Complex II with Cholesterol- and Sphingolipid-rich Membranes Precedes Peptide Loading J. Biol. Chem., August 13, 2004; 279(33): 34818 - 34826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cherukuri, R. H. Carter, S. Brooks, W. Bornmann, R. Finn, C. S. Dowd, and S. K. Pierce B Cell Signaling Is Regulated by Induced Palmitoylation of CD81 J. Biol. Chem., July 23, 2004; 279(30): 31973 - 31982. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
