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1 and E7 Integrins Define a Subset of Dendritic Cells in Peripheral Lymph Nodes with Unique Adhesive and Antigen Uptake Properties 1
Departments of
*
Laboratory Medicine and Pathology and
Microbiology, Center for Immunology, Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455
Dendritic cells (DCs) are a heterogeneous population of APCs with critical roles in T cell activation and immune regulation. We report in this study the identification and characterization of a novel subset of DCs resident in skin-draining peripheral lymph nodes of normal mice. This subset of CD11chighCD40highCD8
intermediate (int) DCs expresses the collagen-binding integrin, 1
1, and the E-cadherin-binding integrin, E7. Although 11 and E7 are also expressed on CD11chighCD40intCD8high lymphoid DCs, CD11chighCD40highCD8int DCs demonstrate preferential integrin-mediated adhesion to collagen and fibronectin. This DC subset most likely acquires expression of these integrins in peripheral lymph node, as this subset is not found in the spleen or mesenteric lymph node, and recent DC migrants from the skin lack expression of 11 and E7 integrins. Resident CD40high DCs express 11 integrin and colocalize with collagen in lymph nodes. When compared with CD11chighCD40highCD8int DCs lacking expression of these integrins, the 11+E7+ DC subset exhibits more efficient formation of Ag-independent conjugates with T cells, and a decreased ability to acquire soluble Ag. Thus, the 11 and E7 integrins define a unique population of peripheral lymph node-derived DCs with altered functional properties and adhesive potential that localizes these cells to sites in lymph nodes where Ag presentation to T cells occurs.
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