The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Related articles in The JI
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schüler, T.
Right arrow Articles by Arnold, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schüler, T.
Right arrow Articles by Arnold, B.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
The Journal of Immunology, 2004, 172: 15-19.
Copyright © 2004 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: IL-7-Dependent Homeostatic Proliferation of CD8+ T Cells in Neonatal Mice Allows the Generation of Long-Lived Natural Memory T Cells 1

Thomas Schüler2, Günter J. Hämmerling and Bernd Arnold

German Cancer Research Center, Heidelberg, Germany

Healthy, nonimmunized C57BL/6 (B6) mice contain memory phenotype CD8+ T cells, which are assumed to be generated in response to environmental Ags. Since neonatal mice are functionally lymphopenic within the first days after birth, we investigated the alternative possibility that the memory CD8+ T cells of untreated B6 mice are the result of lymphopenia-induced proliferation during neonatal life. We show here that adoptively transferred CD8+ T cells proliferate in neonatal B6 mice, rapidly produce IFN-{gamma}, and develop into memory cells which are maintained until adulthood. In contrast to CD4+ T cells, neonatal lymphopenia-induced proliferation of CD8+ T cells was IL-7 dependent. Thus, neonatal lymphopenia seems to allow CD8+ thymic emigrants to undergo lymphopenia-induced proliferation during early neonatal life to equip the immune system with a set of preactivated CD8+ T cells before any infection, which might contribute to the rapid initiation of immune responses in the adult.


Related articles in The JI:

IN THIS ISSUE

The JI 2004 172: 1-2. [Full Text]  



This article has been cited by other articles:


Home page
 JEMHome page
M. Guerau-de-Arellano, M. Martinic, C. Benoist, and D. Mathis
Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
J. Exp. Med., June 8, 2009; 206(6): 1245 - 1252.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. Haluszczak, A. D. Akue, S. E. Hamilton, L. D.S. Johnson, L. Pujanauski, L. Teodorovic, S. C. Jameson, and R. M. Kedl
The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion
J. Exp. Med., February 16, 2009; 206(2): 435 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. E. Hamilton and S. C. Jameson
The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells
PNAS, November 25, 2008; 105(47): 18484 - 18489.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Posevitz, B. Arndt, T. Krieger, N. Warnecke, B. Schraven, and L. Simeoni
Regulation of T Cell Homeostasis by the Transmembrane Adaptor Protein SIT
J. Immunol., February 1, 2008; 180(3): 1634 - 1642.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Xiao, D.-m. Su, and N. R. Manley
Atypical Memory Phenotype T Cells with Low Homeostatic Potential and Impaired TCR Signaling and Regulatory T Cell Function in Foxn1{Delta}/{Delta} Mutant Mice
J. Immunol., December 15, 2007; 179(12): 8153 - 8163.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Sato, H. J. Patel, T. A. Waldmann, and Y. Tagaya
The IL-15/IL-15R{alpha} on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells
PNAS, January 9, 2007; 104(2): 588 - 593.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Burchill, J. Yang, C. Vogtenhuber, B. R. Blazar, and M. A. Farrar
IL-2 Receptor beta-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells
J. Immunol., January 1, 2007; 178(1): 280 - 290.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Bourgeois and B. Stockinger
CD25+CD4+ Regulatory T Cells and Memory T Cells Prevent Lymphopenia-Induced Proliferation of Naive T Cells in Transient States of Lymphopenia
J. Immunol., October 1, 2006; 177(7): 4558 - 4566.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. S. Warren, P. M. Rana, D. T. Rieger, K. A. Hewitt, J. E. Dahlstrom, and A. L. Kent
CD8 T cells expressing killer Ig-like receptors and NKG2A are present in cord blood and express a more naive phenotype than their counterparts in adult blood
J. Leukoc. Biol., June 1, 2006; 79(6): 1252 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Michaelsson, J. E. Mold, J. M. McCune, and D. F. Nixon
Regulation of T Cell Responses in the Developing Human Fetus
J. Immunol., May 15, 2006; 176(10): 5741 - 5748.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. M Strutt, J. Uzonna, K. K McKinstry, and P. A Bretscher
Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC
Int. Immunol., May 1, 2006; 18(5): 719 - 728.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Zaft, A. Sapoznikov, R. Krauthgamer, D. R. Littman, and S. Jung
CD11chigh Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8+ T Cells
J. Immunol., November 15, 2005; 175(10): 6428 - 6435.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L.-X. Wang, S. Shu, and G. E. Plautz
Host Lymphodepletion Augments T Cell Adoptive Immunotherapy through Enhanced Intratumoral Proliferation of Effector Cells
Cancer Res., October 15, 2005; 65(20): 9547 - 9554.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. M. Marleau and N. Sarvetnick
T cell homeostasis in tolerance and immunity
J. Leukoc. Biol., September 1, 2005; 78(3): 575 - 584.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. DeRyckere and J. DeGregori
E2F1 and E2F2 Are Differentially Required for Homeostasis-Driven and Antigen-Induced T Cell Proliferation In Vivo
J. Immunol., July 15, 2005; 175(2): 647 - 655.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. J. Fry and C. L. Mackall
The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance
J. Immunol., June 1, 2005; 174(11): 6571 - 6576.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Min, H. Yamane, J. Hu-Li, and W. E. Paul
Spontaneous and Homeostatic Proliferation of CD4 T Cells Are Regulated by Different Mechanisms
J. Immunol., May 15, 2005; 174(10): 6039 - 6044.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Bourgeois, G. Kassiotis, and B. Stockinger
A Major Role for Memory CD4 T Cells in the Control of Lymphopenia-Induced Proliferation of Naive CD4 T Cells
J. Immunol., May 1, 2005; 174(9): 5316 - 5323.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. L. Bayer, A. Yu, D. Adeegbe, and T. R. Malek
Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period
J. Exp. Med., March 7, 2005; 201(5): 769 - 777.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. G. Zheng, J. H. Wang, J. D. Gray, H. Soucier, and D. A. Horwitz
Natural and Induced CD4+CD25+ Cells Educate CD4+CD25- Cells to Develop Suppressive Activity: The Role of IL-2, TGF-{beta}, and IL-10
J. Immunol., May 1, 2004; 172(9): 5213 - 5221.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.