| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202; and
Departments of Microbiology, Immunology and Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Aberrant activation of autoreactive T cells is one of the major causes of autoimmune disease. Autoantigens are sequestered and in many cases weak immunogens. For example, in experimental autoimmune uveitis, immunization of naive rats with autologous interphotoreceptor retinoid-binding protein (IRBP) fails to induce intraocular inflammation or a strong T cell response, whereas bovine IRBP is a strong inducer of experimental autoimmune uveitis. Such observations challenge the view that the autoantigen alone is responsible for the development of autoimmunity. Here, we demonstrate that autologous rat IRBP is converted to a strong immunogen in the presence of a small dose of CpG-containing oligodeoxynucleotides. Our results indicate that specific CpG-containing oligodeoxynucleotides may play an important role in the activation and expansion of autoreactive T cells in vivo, leading to autoimmune disease.
This article has been cited by other articles:
|
|
 |
|
  Y. Ke, D. Sun, P. Zhang, G. Jiang, H. J. Kaplan, and H. Shao Suppression of Established Experimental Autoimmune Uveitis by Anti-LFA-1{alpha} Ab Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2667 - 2675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Peng, H. Shao, Y. Ke, P. Zhang, G. Han, H. J. Kaplan, and D. Sun Minimally Activated CD8 Autoreactive T Cells Specific for IRBP Express a High Level of Foxp3 and Are Functionally Suppressive Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2178 - 2184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Peng, H. Shao, Y. Ke, P. Zhang, J. Xiang, H. J. Kaplan, and D. Sun In Vitro Activation of CD8 Interphotoreceptor Retinoid-Binding Protein-Specific T Cells Requires not only Antigenic Stimulation but also Exogenous Growth Factors. J. Immunol., April 15, 2006; 176(8): 5006 - 5014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Liao, Y. Ke, W.-H. Shao, B. Haribabu, H. J. Kaplan, D. Sun, and H. Shao Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1543 - 1549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ito, J. Pedras-Vasconcelos, and D. M. Klinman CpG Oligodeoxynucleotides Increase the Susceptibility of Normal Mice to Infection by Candida albicans Infect. Immun., September 1, 2005; 73(9): 6154 - 6156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shao, Y. Peng, T. Liao, M. Wang, M. Song, H. J. Kaplan, and D. Sun A Shared Epitope of the Interphotoreceptor Retinoid-Binding Protein Recognized by the CD4+ and CD8+ Autoreactive T Cells J. Immunol., August 1, 2005; 175(3): 1851 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shao, Y. Fu, T. Liao, Y. Peng, L. Chen, H. J. Kaplan, and D. Sun Anti-CD137 mAb Treatment Inhibits Experimental Autoimmune Uveitis by Limiting Expansion and Increasing Apoptotic Death of Uveitogenic T Cells Invest. Ophthalmol. Vis. Sci., February 1, 2005; 46(2): 596 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shao, Z. Huang, S. L. Sun, H. J. Kaplan, and D. Sun Myelin/Oligodendrocyte Glycoprotein-Specific T-Cells Induce Severe Optic Neuritis in the C57Bl/6 Mouse Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 4060 - 4065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shao, S. L. Sun, H. J. Kaplan, and D. Sun Characterization of Rat CD8+ Uveitogenic T Cells Specific for Interphotoreceptor Retinal-Binding Protein 1177-1191 J. Immunol., August 15, 2004; 173(4): 2849 - 2854. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
