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The Journal of Immunology, 2003, 171: 4630-4638.
Copyright © 2003 by The American Association of Immunologists

Ly49D Receptor Expressed on Immature B Cells Regulates Their IFN-{gamma} Secretion, Actin Polymerization, and Homing1

Gili Hart, Liat Flaishon, Shirly Becker-Herman and Idit Shachar2

Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

Low levels of IFN-{gamma} secreted by immature B cells prevent their own migration and homing to the lymph nodes and premature encounter with Ag. In this study we followed the mechanism regulating IFN-{gamma} secretion by immature B cells. We show that the MHC class I receptor, Ly49D, is expressed on immature B cells and is down-regulated during maturation. Activation of this receptor leads to increase in IFN-{gamma} transcription and translation and results in the altered ability of B cells to polymerize actin in response to chemokine stimulation. Moreover, we show that H2-D blockage inhibits the ability of immature B cells to transcribe the IFN-{gamma} gene and results in rescue of cytoskeletal rearrangement. Thus, Ly49D that is expressed on immature B cells recognizes MHC class I on the peripheral tissues, inducing the secretion of low levels of IFN-{gamma} and thereby down-regulating immature B cell homing to the lymph nodes or to sites of inflammation.




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