The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Related articles in The JI
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Plotkin, J.
Right arrow Articles by Petrie, H. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Plotkin, J.
Right arrow Articles by Petrie, H. T.
The Journal of Immunology, 2003, 171: 4521-4527.
Copyright © 2003 by The American Association of Immunologists

Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus 1

Jason Plotkin*, Susan E. Prockop*, Ana Lepique* and Howard T. Petrie2,*,{dagger}

* Memorial Sloan-Kettering Cancer Center, New York, NY 10021; and {dagger} Joan and Sanford Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021

T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex. Here we show that CXCL12/CXCR4 signaling is absolutely required for proper localization of early progenitors into the cortex and thus for successful steady state differentiation. All early progenitors in the thymus express CXCR4, and its ligand (CXCL12) is expressed only by stromal cells in the cortex, where early progenitors are found. Early progenitors migrate in response to CXCL12 in vitro, while thymus-specific deletion of CXCR4 in vivo results in failed cortical localization and developmental arrest. These findings indicate a crucial and nonredundant role for CXCR4 in facilitating localization of early lymphoid progenitors to tissue regions of the thymus, where lineage commitment and proliferation are controlled.


Related articles in The JI:

IN THIS ISSUE

The JI 2003 171: 4471-4472. [Full Text]  



This article has been cited by other articles:


Home page
 Stem CellsHome page
Z. Galic, S. G. Kitchen, A. Subramanian, G. Bristol, M. D. Marsden, A. Balamurugan, A. Kacena, O. Yang, and J. A. Zack
Generation of T Lineage Cells from Human Embryonic Stem Cells in a Feeder Free System
Stem Cells, January 1, 2009; 27(1): 100 - 107.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y.-W. Chu, S. Schmitz, B. Choudhury, W. Telford, V. Kapoor, S. Garfield, D. Howe, and R. E. Gress
Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion
Blood, October 1, 2008; 112(7): 2836 - 2846.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M.-H. Fortier, E. Caron, M.-P. Hardy, G. Voisin, S. Lemieux, C. Perreault, and P. Thibault
The MHC class I peptide repertoire is molded by the transcriptome
J. Exp. Med., March 17, 2008; 205(3): 595 - 610.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Svensson, J. Marsal, H. Uronen-Hansson, M. Cheng, W. Jenkinson, C. Cilio, S. E. W. Jacobsen, E. Sitnicka, G. Anderson, and W. W. Agace
Involvement of CCR9 at multiple stages of adult T lymphopoiesis
J. Leukoc. Biol., January 1, 2008; 83(1): 156 - 164.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Itoi, N. Tsukamoto, H. Yoshida, and T. Amagai
Mesenchymal cells are required for functional development of thymic epithelial cells
Int. Immunol., August 1, 2007; 19(8): 953 - 964.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Tanaka, T. Era, S.-i. Nishikawa, and S. Kawamata
Forced expression of Nanog in hematopoietic stem cells results in a {gamma}{delta}T-cell disorder
Blood, July 1, 2007; 110(1): 107 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Assarsson, B. J. Chambers, K. Hogstrand, E. Berntman, C. Lundmark, L. Fedorova, S. Imreh, A. Grandien, S. Cardell, B. Rozell, et al.
Severe Defect in Thymic Development in an Insertional Mutant Mouse Model
J. Immunol., April 15, 2007; 178(8): 5018 - 5027.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. S. Perry, R. S. Welner, T. Kouro, P. W. Kincade, and X.-H. Sun
Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential.
J. Immunol., September 1, 2006; 177(5): 2880 - 2887.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. L. Scimone, I. Aifantis, I. Apostolou, H. von Boehmer, and U. H. von Andrian
A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
PNAS, May 2, 2006; 103(18): 7006 - 7011.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Uehara, S. M. Hayes, L. Li, D. El-Khoury, M. Canelles, B. J. Fowlkes, and P. E. Love
Premature Expression of Chemokine Receptor CCR9 Impairs T Cell Development
J. Immunol., January 1, 2006; 176(1): 75 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. L. Curtis
Cell-mediated Adaptive Immune Defense of the Lungs
Proceedings of the ATS, December 1, 2005; 2(5): 412 - 416.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Swainson, S. Kinet, N. Manel, J.-L. Battini, M. Sitbon, and N. Taylor
Glucose transporter 1 expression identifies a population of cycling CD4+CD8+ human thymocytes with high CXCR4-induced chemotaxis
PNAS, September 6, 2005; 102(36): 12867 - 12872.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Zubkova, H. Mostowski, and M. Zaitseva
Up-Regulation of IL-7, Stromal-Derived Factor-1{alpha}, Thymus-Expressed Chemokine, and Secondary Lymphoid Tissue Chemokine Gene Expression in the Stromal Cells in Response to Thymocyte Depletion: Implication for Thymus Reconstitution
J. Immunol., August 15, 2005; 175(4): 2321 - 2330.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Vielkind, M. Gallagher-Gambarelli, M. Gomez, H. J. Hinton, and D. A. Cantrell
Integrin Regulation by RhoA in Thymocytes
J. Immunol., July 1, 2005; 175(1): 350 - 357.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. A. Wysocki, A. Panoskaltsis-Mortari, B. R. Blazar, and J. S. Serody
Leukocyte migration and graft-versus-host disease
Blood, June 1, 2005; 105(11): 4191 - 4199.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Liu, T. Ueno, S. Kuse, F. Saito, T. Nitta, L. Piali, H. Nakano, T. Kakiuchi, M. Lipp, G. A. Hollander, et al.
The role of CCL21 in recruitment of T-precursor cells to fetal thymi
Blood, January 1, 2005; 105(1): 31 - 39.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
V. McNeil Coffield, W. S. Helms, Q. Jiang, and L. Su
G{alpha}13 Mediates a Signal That Is Essential for Proliferation and Survival of Thymocyte Progenitors
J. Exp. Med., November 15, 2004; 200(10): 1315 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Ueno, F. Saito, D. H.D. Gray, S. Kuse, K. Hieshima, H. Nakano, T. Kakiuchi, M. Lipp, R. L. Boyd, and Y. Takahama
CCR7 Signals Are Essential for Cortex-Medulla Migration of Developing Thymocytes
J. Exp. Med., August 16, 2004; 200(4): 493 - 505.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Misslitz, O. Pabst, G. Hintzen, L. Ohl, E. Kremmer, H. T. Petrie, and R. Forster
Thymic T Cell Development and Progenitor Localization Depend on CCR7
J. Exp. Med., August 16, 2004; 200(4): 481 - 491.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. M. Witt and E. A. Robey
The Ins and Outs of CCR7 in the Thymus
J. Exp. Med., August 16, 2004; 200(4): 405 - 409.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Tabrizifard, A. Olaru, J. Plotkin, M. Fallahi-Sichani, F. Livak, and H. T. Petrie
Analysis of Transcription Factor Expression during Discrete Stages of Postnatal Thymocyte Differentiation
J. Immunol., July 15, 2004; 173(2): 1094 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
W. Savino, D. A. Mendes-da-Cruz, S. Smaniotto, E. Silva-Monteiro, and D. M. S. Villa-Verde
Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrix
J. Leukoc. Biol., June 1, 2004; 75(6): 951 - 961.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Kwan and N. Killeen
CCR7 Directs the Migration of Thymocytes into the Thymic Medulla
J. Immunol., April 1, 2004; 172(7): 3999 - 4007.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.