| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Gastroenterology and Hepatology,
Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan;
Department of Surgery, Yokohama City Hospital, Yokohama, Japan;
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan; and
¶
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905
A newly identified costimulatory molecule, programmed death-1 (PD-1), provides a negative signal that is essential for immune homeostasis. However, it has been suggested that its ligands, B7-H1 (PD-L1) and B7-dendritic cells (B7-DC; PD-L2), could also costimulate T cell proliferation and cytokine secretion. Here we demonstrate the involvement of PD-1/B7-H1 and B7-DC interaction in the development of colitis. We first examined the expression profiles of PD-1 and its ligands in both human inflammatory bowel disease and a murine chronic colitis model induced by adoptive transfer of CD4+CD45RBhigh T cells to SCID mice. Second, we assessed the therapeutic potential of neutralizing anti-B7-H1 and/or B7-DC mAbs using this colitis model. We found significantly increased expression of PD-1 on T cells and of B7-H1 on T, B, and macrophage/DCs in inflamed colon from both inflammatory bowel disease patients and colitic mice. Unexpectedly, the administration of anti-B7-H1, but not anti-B7-DC, mAb after transfer of CD4+CD45RBhigh T cells suppressed wasting disease with colitis, abrogated leukocyte infiltration, and reduced the production of IFN-
, IL-2, and TNF-
, but not IL-4 or IL-10, by lamina propria CD4+ T cells. These data suggest that the interaction of PD-1/B7-H1, but not PD-1/B7-DC, might be involved in intestinal mucosal inflammation and also show a possible role of interaction between B7-H1 and an as yet unidentified receptor for B7-H1 in inducing T cell activation.
This article has been cited by other articles:
|
|
 |
|
  T. W. Phares, C. Ramakrishna, G. I. Parra, A. Epstein, L. Chen, R. Atkinson, S. A. Stohlman, and C. C. Bergmann Target-Dependent B7-H1 Regulation Contributes to Clearance of Central Nervous Sysyem Infection and Dampens Morbidity J. Immunol., May 1, 2009; 182(9): 5430 - 5438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Onizawa, T. Nagaishi, T. Kanai, K.-i. Nagano, S. Oshima, Y. Nemoto, A. Yoshioka, T. Totsuka, R. Okamoto, T. Nakamura, et al. Signaling pathway via TNF-{alpha}/NF-{kappa}B in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Am J Physiol Gastrointest Liver Physiol, April 1, 2009; 296(4): G850 - G859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Finnefrock, A. Tang, F. Li, D. C. Freed, M. Feng, K. S. Cox, K. J. Sykes, J. P. Guare, M. D. Miller, D. B. Olsen, et al. PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination J. Immunol., January 15, 2009; 182(2): 980 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Gotsman, A. H. Sharpe, and A. H. Lichtman T-Cell Costimulation and Coinhibition in Atherosclerosis Circ. Res., November 21, 2008; 103(11): 1220 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Kim, G. B. Park, H.-K. Lee, H. Song, I.-H. Choi, W. J. Lee, and D. Y. Hur Cross-Linking of B7-H1 on EBV-Transformed B Cells Induces Apoptosis through Reactive Oxygen Species Production, JNK Signaling Activation, and fasL Expression J. Immunol., November 1, 2008; 181(9): 6158 - 6169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Rowe, T. M. Johanns, J. M. Ertelt, and S. S. Way PDL-1 Blockade Impedes T Cell Expansion and Protective Immunity Primed by Attenuated Listeria monocytogenes J. Immunol., June 1, 2008; 180(11): 7553 - 7557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, A. Hamrouni, D. Wolowiec, V. Coiteux, K. Kuliczkowski, D. Hetuin, A. Saudemont, and B. Quesnel Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway Blood, July 1, 2007; 110(1): 296 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Smith, N. E. Mangan, C. M. Walsh, R. E. Fallon, A. N. J. McKenzie, N. van Rooijen, and P. G. Fallon Infection with a Helminth Parasite Prevents Experimental Colitis via a Macrophage-Mediated Mechanism J. Immunol., April 1, 2007; 178(7): 4557 - 4566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hori, M. Wang, M. Miyashita, K. Tanemoto, H. Takahashi, T. Takemori, K. Okumura, H. Yagita, and M. Azuma B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts J. Immunol., November 1, 2006; 177(9): 5928 - 5935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fujii, T. Kanai, Y. Nemoto, S. Makita, S. Oshima, R. Okamoto, K. Tsuchiya, T. Totsuka, and M. Watanabe FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G267 - G274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kanai, K. Tanimoto, Y. Nemoto, R. Fujii, S. Makita, T. Totsuka, and M. Watanabe Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L- effector memory T cells Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G1051 - G1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Kim, H. Guan, G. Zu, H. Li, L. Wu, X. Feng, C. Elmets, Y. Fu, and H. Xu High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals J. Leukoc. Biol., April 1, 2006; 79(4): 686 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakae, H. Suto, M. Iikura, M. Kakurai, J. D. Sedgwick, M. Tsai, and S. J. Galli Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF J. Immunol., February 15, 2006; 176(4): 2238 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saudemont, N. Jouy, D. Hetuin, and B. Quesnel NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells Blood, March 15, 2005; 105(6): 2428 - 2435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hirano, K. Kaneko, H. Tamura, H. Dong, S. Wang, M. Ichikawa, C. Rietz, D. B. Flies, J. S. Lau, G. Zhu, et al. Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity Cancer Res., February 1, 2005; 65(3): 1089 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saudemont and B. Quesnel In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis Blood, October 1, 2004; 104(7): 2124 - 2133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Oei, T. Kalb, P. Beuria, M. Allez, A. Nakazawa, M. Azuma, M. Timony, Z. Stuart, H. Chen, and K. Sperber Accessory cell function of airway epithelial cells Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L318 - L331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Prokunina and M. Alarcon-Riquelme The genetic basis of systemic lupus erythematosus--knowledge of today and thoughts for tomorrow Hum. Mol. Genet., April 1, 2004; 13(90001): R143 - 148. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
