| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Immunology and
Central Support Unit Microscopy, Max-Planck- Institute for Infection Biology, Berlin, Germany; and
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
LFA-1 (CD11a/CD18) plays a key role in various inflammatory responses. Here we show that the acquired immune response to Listeria monocytogenes is highly biased toward type 1 in the absence of LFA-1. At the early stage of listeriosis, numbers of IFN-
producers in the liver and spleen of LFA-1-/- mice were markedly increased compared with heterozygous littermates and V
14+NKT cell-deficient mice, and NK cells were major IFN- producers. Numbers of IL-12 producers were also markedly elevated in LFA-1-/- mice compared with heterozygous littermates, and endogenous IL-12 neutralization impaired IFN- production by NK cells. Granulocyte depletion diminished numbers of IL-12 producers and IFN--secreting NK cells in the liver of LFA-1-/- mice. Granulocytes from the liver of L. monocytogenes-infected LFA-1-/- mice were potent IL-12 producers. Thus, in the absence of LFA-1, granulocytes are a major source of IL-12 at the early stage of listeriosis. We assume that highly biased type 1 immune responses in LFA-1-/- mice are caused by increased levels of IL-12 from granulocytes and that granulocytes play a major role in IFN- secretion by NK cells. In conclusion, LFA-1 regulates type 1 immune responses by controlling prompt infiltration of IL-12-producing granulocytes into sites of inflammation.
This article has been cited by other articles:
|
|
 |
|
  S.-H. Lee, J. E. Prince, M. Rais, F. Kheradmand, C. M. Ballantyne, G. Weitz-Schmidt, C. W. Smith, and D. B. Corry Developmental Control of Integrin Expression Regulates Th2 Effector Homing J. Immunol., April 1, 2008; 180(7): 4656 - 4667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kesteman, G. Vansanten, B. Pajak, S. M. Goyert, and M. Moser Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines J. Leukoc. Biol., March 1, 2008; 83(3): 640 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Graf, T. Bushnell, and J. Miller LFA-1-Mediated T Cell Costimulation through Increased Localization of TCR/Class II Complexes to the Central Supramolecular Activation Cluster and Exclusion of CD45 from the Immunological Synapse J. Immunol., August 1, 2007; 179(3): 1616 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ghosh, A. A. Chackerian, C. M. Parker, C. M. Ballantyne, and S. M. Behar The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. J. Immunol., April 15, 2006; 176(8): 4914 - 4922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Park, M. T. Wiekowski, S. A. Lira, and B. Mehrad Neutrophils Regulate Airway Responses in a Model of Fungal Allergic Airways Disease J. Immunol., February 15, 2006; 176(4): 2538 - 2545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Duthie, M. Kahn, M. White, R. P. Kapur, and S. J. Kahn Critical Proinflammatory and Anti-Inflammatory Functions of Different Subsets of CD1d-Restricted Natural Killer T Cells during Trypanosoma cruzi Infection Infect. Immun., January 1, 2005; 73(1): 181 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matsumoto, E. Kubota, Y. Omi, U. Lee, and J. M. Penninger Essential Role of LFA-1 in Activating Th2-Like Responses by {alpha}-Galactosylceramide-Activated NKT Cells J. Immunol., October 15, 2004; 173(8): 4976 - 4984. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
