The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dorsam, G.
Right arrow Articles by Goetzl, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dorsam, G.
Right arrow Articles by Goetzl, E. J.
The Journal of Immunology, 2003, 171: 3500-3507.
Copyright © 2003 by The American Association of Immunologists

Transduction of Multiple Effects of Sphingosine 1-Phosphate (S1P) on T Cell Functions by the S1P1 G Protein-Coupled Receptor 1

Glenn Dorsam2,*, Markus H. Graeler2,*, Christine Seroogy{dagger}, Yvonne Kong*, Julia K. Voice* and Edward J. Goetzl3,*

* Departments of Medicine and Immunology, University of California, San Francisco, CA 94143; and {dagger} Stanford University Medical Center, Stanford, CA 94305

Sphingosine 1-phosphate (S1P) in blood, lymph, and immune tissues stimulates and regulates T cell migration through their S1P1 (endothelial differentiation gene encoded receptor-1) G protein-coupled receptors. We show now that S1P1Rs also mediate suppression of T cell proliferation and cytokine production. Uptake of [3H]thymidine by mouse CD4 T cells stimulated with anti-CD3 mAbs plus either anti-CD28 or IL-7 was inhibited up to 50% by 10-9–10-6 M S1P. Suppression by S1P required Ca2+ signaling and was reduced by intracellular cAMP. S1P decreased CD4 T cell generation of IFN-{gamma} and IL-4, without affecting IL-2. A Th1 line from D011.10 TCR transgenic mice without detectable S1P1 was refractory to S1P until introduction of S1P1 by retroviral transduction. S1P then evoked chemotaxis, inhibited chemotaxis to CCL-5 and CCL-21, and suppressed Ag-stimulated proliferation and IFN-{gamma} production. Thus, S1P1 signals multiple immune functions of T cells as well as migration and tissue distribution.




This article has been cited by other articles:


Home page
 FASEB J.Home page
J.-J. Liao, M.-C. Huang, K. Fast, K. Gundling, M. Yadav, J. R. Van Brocklyn, M. R. Wabl, and E. J. Goetzl
Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor
FASEB J, June 1, 2009; 23(6): 1786 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
C. Zhao, M. J. Fernandes, M. Turgeon, S. Tancrede, J. Di Battista, P. E. Poubelle, and S. G. Bourgoin
Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-{alpha}
J. Lipid Res., November 1, 2008; 49(11): 2323 - 2337.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Sekiguchi, T. Iwasaki, M. Kitano, H. Kuno, N. Hashimoto, Y. Kawahito, M. Azuma, T. Hla, and H. Sano
Role of Sphingosine 1-Phosphate in the Pathogenesis of Sjogren's Syndrome
J. Immunol., February 1, 2008; 180(3): 1921 - 1928.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Srinivasan, D. T. Bolick, D. Lukashev, C. Lappas, M. Sitkovsky, K. R. Lynch, and C. C. Hedrick
Sphingosine-1-Phosphate Reduces CD4+ T-Cell Activation in Type 1 Diabetes Through Regulation of Hypoxia-Inducible Factor Short Isoform I.1 and CD69
Diabetes, February 1, 2008; 57(2): 484 - 493.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
K. M. Argraves and W. S. Argraves
HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects
J. Lipid Res., November 1, 2007; 48(11): 2325 - 2333.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-C. Huang, S. R. Watson, J.-J. Liao, and E. J. Goetzl
Th17 Augmentation in OTII TCR Plus T Cell-Selective Type 1 Sphingosine 1-Phosphate Receptor Double Transgenic Mice
J. Immunol., June 1, 2007; 178(11): 6806 - 6813.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-J. Liao, M.-C. Huang, and E. J. Goetzl
Cutting Edge: Alternative Signaling of Th17 Cell Development by Sphingosine 1-Phosphate
J. Immunol., May 1, 2007; 178(9): 5425 - 5428.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Wang, M.-C. Huang, and E. J. Goetzl
Type 1 Sphingosine 1-Phosphate G Protein-Coupled Receptor (S1P1) Mediation of Enhanced IL-4 Generation by CD4 T Cells from S1P1 Transgenic Mice
J. Immunol., April 15, 2007; 178(8): 4885 - 4890.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J.-R. Nofer, M. Bot, M. Brodde, P. J. Taylor, P. Salm, V. Brinkmann, T. van Berkel, G. Assmann, and E. A.L. Biessen
FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-Density Lipoprotein Receptor Deficient Mice
Circulation, January 30, 2007; 115(4): 501 - 508.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-J. Liao, M.-C. Huang, M. Graler, Y. Huang, H. Qiu, and E. J. Goetzl
Distinctive T Cell-suppressive Signals from Nuclearized Type 1 Sphingosine 1-Phosphate G Protein-coupled Receptors
J. Biol. Chem., January 19, 2007; 282(3): 1964 - 1972.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Yang, B. E. Castle, A. Hanidu, L. Stevens, Y. Yu, X. Li, C. Stearns, V. Papov, D. Rajotte, and J. Li
Sphingosine Kinase 1 Is a Negative Regulator of CD4+ Th1 Cells
J. Immunol., November 15, 2005; 175(10): 6580 - 6588.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Chi and R. A. Flavell
Cutting Edge: Regulation of T Cell Trafficking and Primary Immune Responses by Sphingosine 1-Phosphate Receptor 1
J. Immunol., March 1, 2005; 174(5): 2485 - 2488.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. H. Graler, M.-C. Huang, S. Watson, and E. J. Goetzl
Immunological Effects of Transgenic Constitutive Expression of the Type 1 Sphingosine 1-Phosphate Receptor by Mouse Lymphocytes
J. Immunol., February 15, 2005; 174(4): 1997 - 2003.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Roviezzo, F. Del Galdo, G. Abbate, M. Bucci, B. D'Agostino, E. Antunes, G. De Dominicis, L. Parente, F. Rossi, G. Cirino, et al.
Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate
PNAS, July 27, 2004; 101(30): 11170 - 11175.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
E. J. Goetzl and M. H. Graler
Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T Lymphocytes
J. Leukoc. Biol., July 1, 2004; 76(1): 30 - 35.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Forrest, S.-Y. Sun, R. Hajdu, J. Bergstrom, D. Card, G. Doherty, J. Hale, C. Keohane, C. Meyers, J. Milligan, et al.
Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes
J. Pharmacol. Exp. Ther., May 1, 2004; 309(2): 758 - 768.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. L. Allende, J. L. Dreier, S. Mandala, and R. L. Proia
Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration
J. Biol. Chem., April 9, 2004; 279(15): 15396 - 15401.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.