| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
* Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan;
Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan;
Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; and
Division of Cell Regeneration, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
We have previously shown that the earliest thymic progenitors retain the potential to generate T and NK cells and that they lose the bipotentiality to give rise to unipotent T and NK progenitors during the progression of intrathymic developmental stages. The present study examines the ability of these thymic progenitors for generation of dendritic cells (DC) with a new clonal assay that is capable of determining the developmental potential for DC in addition to T cells and NK cells. We found that the large majority of the T/NK bipotential progenitors in the earliest population of fetal thymus was able to generate DC. Although the DC potential is lost with the progression of the differentiation stage, some of the T/NK bipotential progenitors still retain their DC potential even at the CD44+CD25+ stage.
Related articles in The JI:
This article has been cited by other articles:
|
|
 |
|
  U. I. Chaudhry, G. Plitas, B. M. Burt, T. P. Kingham, J. R. Raab, and R. P. DeMatteo NK Dendritic Cells Expanded in IL-15 Exhibit Antitumor Responses In Vivo J. Immunol., October 1, 2007; 179(7): 4654 - 4660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Masuda, K. Kakugawa, T. Nakayama, N. Minato, Y. Katsura, and H. Kawamoto T Cell Lineage Determination Precedes the Initiation of TCRbeta Gene Rearrangement J. Immunol., September 15, 2007; 179(6): 3699 - 3706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Tydell, E.-S. David-Fung, J. E. Moore, L. Rowen, T. Taghon, and E. V. Rothenberg Molecular Dissection of Prethymic Progenitor Entry into the T Lymphocyte Developmental Pathway J. Immunol., July 1, 2007; 179(1): 421 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Tsukumo, K. Hirose, Y. Maekawa, K. Kishihara, and K. Yasutomo Lunatic Fringe Controls T Cell Differentiation through Modulating Notch Signaling J. Immunol., December 15, 2006; 177(12): 8365 - 8371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. I. Chaudhry, T. P. Kingham, G. Plitas, S. C. Katz, J. R. Raab, and R. P. DeMatteo Combined Stimulation with Interleukin-18 and CpG Induces Murine Natural Killer Dendritic Cells to Produce IFN-{gamma} and Inhibit Tumor Growth Cancer Res., November 1, 2006; 66(21): 10497 - 10504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ito, E. Esashi, T. Akiyama, J.-i. Inoue, and A. Miyajima IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymus Int. Immunol., August 1, 2006; 18(8): 1253 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. I. Chaudhry, S. C. Katz, T. P. Kingham, V. G. Pillarisetty, J. R. Raab, A. B. Shah, and R. P. DeMatteo In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells FASEB J, May 1, 2006; 20(7): 982 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Freud, A. Yokohama, B. Becknell, M. T. Lee, H. C. Mao, A. K. Ferketich, and M. A. Caligiuri Evidence for discrete stages of human natural killer cell differentiation in vivo J. Exp. Med., April 17, 2006; 203(4): 1033 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Dontje, R. Schotte, T. Cupedo, M. Nagasawa, F. Scheeren, R. Gimeno, H. Spits, and B. Blom Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B Blood, March 15, 2006; 107(6): 2446 - 2452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lu, R. Tayu, T. Ikawa, K. Masuda, I. Matsumoto, H. Mugishima, H. Kawamoto, and Y. Katsura The Earliest Thymic Progenitors in Adults Are Restricted to T, NK, and Dendritic Cell Lineage and Have a Potential to Form More Diverse TCR{beta} Chains than Fetal Progenitors J. Immunol., November 1, 2005; 175(9): 5848 - 5856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Masuda, M. Itoi, T. Amagai, N. Minato, Y. Katsura, and H. Kawamoto Thymic Anlage Is Colonized by Progenitors Restricted to T, NK, and Dendritic Cell Lineages J. Immunol., March 1, 2005; 174(5): 2525 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. G. Pillarisetty, S. C. Katz, J. I. Bleier, A. B. Shah, and R. P. DeMatteo Natural Killer Dendritic Cells Have Both Antigen Presenting and Lytic Function and in Response to CpG Produce IFN-{gamma} via Autocrine IL-12 J. Immunol., March 1, 2005; 174(5): 2612 - 2618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Schmitt, M. Ciofani, H. T. Petrie, and J. C. Zuniga-Pflucker Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor-Ligand Interactions J. Exp. Med., August 16, 2004; 200(4): 469 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Perry, H. Wang, L. J. Pierce, A. M. Yang, S. Tsai, and G. J. Spangrude L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor Blood, April 15, 2004; 103(8): 2990 - 2996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ikawa, K. Masuda, M. Lu, N. Minato, Y. Katsura, and H. Kawamoto Identification of the earliest prethymic T-cell progenitors in murine fetal blood Blood, January 15, 2004; 103(2): 530 - 537. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
