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Cutting Edge: T Cells from Aged Mice Are Resistant to Depletion Early During Virus Infection¹

Jiu Jiang^*, Farvardin Anaraki^*, Kenneth J. Blank and Donna M. Murasko^2,*,

Departments of ^* Microbiology and Immunology, and Pathology, College of Medicine, and Department of Bioscience and Biotechnology, College of Arts and Sciences, Drexel University, Philadelphia, PA 19129

Aging is associated with decreased expansion of T cells upon stimulation. In young mice, infection induces a transient T cell depletion followed by the development of an Ag-specific T cell response that controls the infection. We found that T cells were depleted early after infection with E55 + murine leukemia retrovirus in young, but not aged, mice. Adoptive transfer experiments showed donor T cells of young, but not aged, mice were depleted due to apoptosis in various tissues of young recipients. However, T cells of neither young nor aged donors were depleted in aged recipients. These results indicate that both environmental and intrinsic cellular properties limit depletion of T cells of aged mice and suggest a novel explanation for the decreased T cell response associated with aging.

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