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CUTTING EDGE |
* University of California San Francisco Diabetes Center, University of California, San Francisco, CA 94143;
Committee on Immunology, University of Chicago, Chicago, IL 60637; and
Division of Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215
CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4+CD25+ regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.
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K. Loser, A. Scherer, M. B. W. Krummen, G. Varga, T. Higuchi, T. Schwarz, A. H. Sharpe, S. Grabbe, J. A. Bluestone, and S. Beissert An Important Role of CD80/CD86-CTLA-4 Signaling during Photocarcinogenesis in Mice J. Immunol., May 1, 2005; 174(9): 5298 - 5305. [Abstract] [Full Text] [PDF]
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H. Kataoka, S. Takahashi, K. Takase, S. Yamasaki, T. Yokosuka, T. Koike, and T. Saito CD25+CD4+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4 Int. Immunol., April 1, 2005; 17(4): 421 - 427. [Abstract] [Full Text] [PDF]
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B. Valzasina, C. Guiducci, H. Dislich, N. Killeen, A. D. Weinberg, and M. P. Colombo Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR Blood, April 1, 2005; 105(7): 2845 - 2851. [Abstract] [Full Text] [PDF]
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S. Liang, P. Alard, Y. Zhao, S. Parnell, S. L. Clark, and M. M. Kosiewicz Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus J. Exp. Med., January 3, 2005; 201(1): 127 - 137. [Abstract] [Full Text] [PDF]
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J. L. Riley and C. H. June The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation Blood, January 1, 2005; 105(1): 13 - 21. [Abstract] [Full Text] [PDF]
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G. L. Stephens, R. S. McHugh, M. J. Whitters, D. A. Young, D. Luxenberg, B. M. Carreno, M. Collins, and E. M. Shevach Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells J. Immunol., October 15, 2004; 173(8): 5008 - 5020. [Abstract] [Full Text] [PDF]
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J. Lohr, B. Knoechel, E. C. Kahn, and A. K. Abbas Role of B7 in T Cell Tolerance J. Immunol., October 15, 2004; 173(8): 5028 - 5035. [Abstract] [Full Text] [PDF]
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J. A. Bluestone and Q. Tang Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells PNAS, October 5, 2004; 101(suppl_2): 14622 - 14626. [Abstract] [Full Text] [PDF]
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J. Machen, J. Harnaha, R. Lakomy, A. Styche, M. Trucco, and N. Giannoukakis Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells J. Immunol., October 1, 2004; 173(7): 4331 - 4341. [Abstract] [Full Text] [PDF]
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K. A. Hagen, C. T. Moses, E. F. Drasler, K. M. Podetz-Pedersen, S. C. Jameson, and A. Khoruts A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells J. Immunol., September 15, 2004; 173(6): 3909 - 3915. [Abstract] [Full Text] [PDF]
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G. Zheng, B. Wang, and A. Chen The 4-1BB Costimulation Augments the Proliferation of CD4+CD25+ Regulatory T Cells J. Immunol., August 15, 2004; 173(4): 2428 - 2434. [Abstract] [Full Text] [PDF]
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H. Shao, S. L. Sun, H. J. Kaplan, and D. Sun Characterization of Rat CD8+ Uveitogenic T Cells Specific for Interphotoreceptor Retinal-Binding Protein 1177-1191 J. Immunol., August 15, 2004; 173(4): 2849 - 2854. [Abstract] [Full Text] [PDF]
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C. Vasu, B. S. Prabhakar, and M. J. Holterman Targeted CTLA-4 Engagement Induces CD4+CD25+CTLA-4high T Regulatory Cells with Target (Allo)antigen Specificity J. Immunol., August 15, 2004; 173(4): 2866 - 2876. [Abstract] [Full Text] [PDF]
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P. Hoffmann, R. Eder, L. A. Kunz-Schughart, R. Andreesen, and M. Edinger Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells Blood, August 1, 2004; 104(3): 895 - 903. [Abstract] [Full Text] [PDF]
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E. A. Wohlfert, M. K. Callahan, and R. B. Clark Resistance to CD4+CD25+ Regulatory T Cells and TGF-{beta} in Cbl-b-/- Mice J. Immunol., July 15, 2004; 173(2): 1059 - 1065. [Abstract] [Full Text] [PDF]
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M. Mamura, W. Lee, T. J. Sullivan, A. Felici, A. L. Sowers, J. P. Allison, and J. J. Letterio CD28 disruption exacerbates inflammation in Tgf-{beta}1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-{beta}1 Blood, June 15, 2004; 103(12): 4594 - 4601. [Abstract] [Full Text] [PDF]
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Q. Tang, K. J. Henriksen, M. Bi, E. B. Finger, G. Szot, J. Ye, E. L. Masteller, H. McDevitt, M. Bonyhadi, and J. A. Bluestone In Vitro-expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes J. Exp. Med., June 7, 2004; 199(11): 1455 - 1465. [Abstract] [Full Text] [PDF]
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A. M. Thornton, E. E. Donovan, C. A. Piccirillo, and E. M. Shevach Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function J. Immunol., June 1, 2004; 172(11): 6519 - 6523. [Abstract] [Full Text] [PDF]
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