The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuh, W.
Right arrow Articles by Jäck, H.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuh, W.
Right arrow Articles by Jäck, H.-M.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*UniGene
*Substance via MeSH
The Journal of Immunology, 2003, 171: 3343-3347.
Copyright © 2003 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Signaling and Cell Surface Expression of a µH Chain in the Absence of {lambda}5: A Paradigm Revisited1

Wolfgang Schuh2, Silke Meister2, Edith Roth and Hans-Martin Jäck3

Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus-Fiebiger Center, University of Erlangen-Nürnberg, Erlangen, Germany

Pre-B cell receptor (pre-BCR) signals are essential for pro-B cells to mature efficiently into pre-B cells. The pre-BCR is an Ig-like transmembrane complex that is assembled from two µH chains (µHC) and two surrogate L chains consisting of the non-covalently associated polypeptides VpreB and {lambda}5. In {lambda}5-/- mice, pro-B cell maturation is impaired, but not completely blocked, implying that a µHC induces differentiation signals in the absence of {lambda}5. Using a mouse model, in which transgenic µHC expression can be controlled by tetracycline, we show that in the absence of {lambda}5, the transgenic µHC promotes in vivo differentiation of pro-B cells, induces IL-7-dependent cell growth, and is expressed on the surface of pre-B cells. Our findings not only show that an incomplete pre-BCR can initiate signals, but also challenge the paradigm that an IgHC must associate with an IgLC or a SLC to gain transport and signaling competency.




This article has been cited by other articles:


Home page
 RNAHome page
A. B. Eberle, K. Herrmann, H.-M. Jack, and O. Muhlemann
Equal transcription rates of productively and nonproductively rearranged immunoglobulin {micro} heavy chain alleles in a pro-B cell line
RNA, June 1, 2009; 15(6): 1021 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. B. Nakajima, K. Kiefer, A. Price, G. C. Bosma, and M. J. Bosma
Two Distinct Populations of H Chain-Edited B Cells Show Differential Surrogate L Chain Dependence
J. Immunol., March 15, 2009; 182(6): 3583 - 3596.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Vettermann, K. Herrmann, C. Albert, E. Roth, M. R. Bosl, and H.-M. Jack
A Unique Role for the {lambda}5 Nonimmunoglobulin Tail in Early B Lymphocyte Development
J. Immunol., September 1, 2008; 181(5): 3232 - 3242.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Achour, P. Cavelier, M. Tichit, C. Bouchier, P. Lafaye, and F. Rougeon
Tetrameric and Homodimeric Camelid IgGs Originate from the Same IgH Locus
J. Immunol., August 1, 2008; 181(3): 2001 - 2009.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Geraldes, M. Rebrovich, K. Herrmann, J. Wong, H.-M. Jack, M. Wabl, and M. Cascalho
Ig Heavy Chain Promotes Mature B Cell Survival in the Absence of Light Chain
J. Immunol., August 1, 2007; 179(3): 1659 - 1668.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Meister, U. Schubert, K. Neubert, K. Herrmann, R. Burger, M. Gramatzki, S. Hahn, S. Schreiber, S. Wilhelm, M. Herrmann, et al.
Extensive Immunoglobulin Production Sensitizes Myeloma Cells for Proteasome Inhibition
Cancer Res., February 15, 2007; 67(4): 1783 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. M. Fuentes-Panana, G. Bannish, F. G. Karnell, J. F. Treml, and J. G. Monroe
Analysis of the Individual Contributions of Ig{alpha} (CD79a)- and Igbeta (CD79b)-Mediated Tonic Signaling for Bone Marrow B Cell Development and Peripheral B Cell Maturation
J. Immunol., December 1, 2006; 177(11): 7913 - 7922.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zou, J. A. Smith, V. K. Nguyen, L. Ren, K. Luyten, S. Muyldermans, and M. Bruggemann
Expression of a Dromedary Heavy Chain-Only Antibody and B Cell Development in the Mouse
J. Immunol., September 15, 2005; 175(6): 3769 - 3779.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. B. Guloglu, E. Bajor, B. P. Smith, and C. A. J. Roman
The Unique Region of Surrogate Light Chain Component {lambda}5 Is a Heavy Chain-Specific Regulator of Precursor B Cell Receptor Signaling
J. Immunol., July 1, 2005; 175(1): 358 - 366.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. A. J. Vosshenrich, A. Cumano, W. Muller, J. P. Di Santo, and P. Vieira
Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment
PNAS, July 27, 2004; 101(30): 11070 - 11075.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Corcos, H.-M. Jack, W. Schuh, S. Meister, and E. Roth
Signaling and Cell Surface Expression of {micro}H Chains in the Absence of Light Chains
J. Immunol., January 1, 2004; 172(1): 4 - 5.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.