| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
4+ 
T Cells Regulate Airway Hyperreactivity to Methacholine in Ovalbumin-Sensitized and Challenged Mice 1
* Department of Immunology,
Division of Cell Biology, Department of Pediatrics at National Jewish Medical and Research Center, Denver, CO 80206; and
Department of Pediatrics, Chungbuk National University and College of Medicine, Cheongju, Korea
The V
4+ pulmonary subset of 
T cells regulates innate airway responsiveness in the absence of 
T cells. We now have examined the same subset in a model of allergic airway disease, OVA-sensitized and challenged mice that exhibit Th2 responses, pulmonary inflammation, and airway hyperreactivity (AHR). In sensitized mice, V4+ cells preferentially increased in number following airway challenge. Depletion of V4+ cells before the challenge substantially increased AHR in these mice, but had no effect on airway responsiveness in normal, nonchallenged mice. Depletion of V1+ cells had no effect on AHR, and depletion of all TCR-+ cells was no more effective than depletion of V4+ cells alone. Adoptively transferred pulmonary lymphocytes containing V4+ cells inhibited AHR, but lost this ability when V4+ cells were depleted, indicating that these cells actively suppress AHR. Eosinophilic infiltration of the lung and airways, or goblet cell hyperplasia, was not affected by depletion of V4+ cells, although cytokine-producing T cells in the lung increased. These findings establish V4+ T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR.
This article has been cited by other articles:
|
|
 |
|
  Y. Huang, N. Jin, C. L. Roark, M. K. Aydintug, J. M. Wands, H. Huang, R. L. O'Brien, and W. K. Born The Influence of IgE-Enhancing and IgE-Suppressive {gamma}{delta} T Cells Changes with Exposure to Inhaled Ovalbumin J. Immunol., July 15, 2009; 183(2): 849 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. O'Brien, M. A. Taylor, J. Hartley, T. Nuhsbaum, S. Dugan, K. Lahmers, M. K. Aydintug, J. M. Wands, C. L. Roark, and W. K. Born Protective Role of {gamma}{delta} T Cells in Spontaneous Ocular Inflammation Invest. Ophthalmol. Vis. Sci., July 1, 2009; 50(7): 3266 - 3274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Matsubara, K. Takeda, N. Jin, M. Okamoto, H. Matsuda, Y. Shiraishi, J. W. Park, G. McConville, A. Joetham, R. L. O'Brien, et al. V{gamma}1+ T Cells and Tumor Necrosis Factor-Alpha in Ozone-Induced Airway Hyperresponsiveness Am. J. Respir. Cell Mol. Biol., April 1, 2009; 40(4): 454 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jin, C. L. Roark, N. Miyahara, C. Taube, M. K. Aydintug, J. M. Wands, Y. Huang, Y.-S. Hahn, E. W. Gelfand, R. L. O'Brien, et al. Allergic Airway Hyperresponsiveness-Enhancing {gamma}{delta} T Cells Develop in Normal Untreated Mice and Fail to Produce IL-4/13, Unlike Th2 and NKT Cells J. Immunol., February 15, 2009; 182(4): 2002 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Kim, D. A. Witherden, and W. L. Havran Characterization and TCR variable region gene use of mouse resident nasal {gamma}{delta} T lymphocytes J. Leukoc. Biol., November 1, 2008; 84(5): 1259 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cook, N. Miyahara, N. Jin, J. M. Wands, C. Taube, C. L. Roark, T. A. Potter, E. W. Gelfand, R. L. O'Brien, and W. K. Born Evidence That CD8+ Dendritic Cells Enable the Development of {gamma}{delta} T Cells That Modulate Airway Hyperresponsiveness J. Immunol., July 1, 2008; 181(1): 309 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Penido, M. F. S. Costa, M. C. Souza, K. A. Costa, A. L. P. Candea, C. F. Benjamim, and M. d. G. M. O. Henriques Involvement of CC chemokines in {gamma}{delta} T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway Int. Immunol., January 1, 2008; 20(1): 129 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Roark, J. D. French, M. A. Taylor, A. M. Bendele, W. K. Born, and R. L. O'Brien Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing {gamma}{delta} T Cells J. Immunol., October 15, 2007; 179(8): 5576 - 5583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jin, N. Miyahara, C. L. Roark, J. D. French, M. K. Aydintug, J. L. Matsuda, L. Gapin, R. L. O'Brien, E. W. Gelfand, and W. K. Born Airway Hyperresponsiveness through Synergy of {gamma}{delta} T Cells and NKT Cells J. Immunol., September 1, 2007; 179(5): 2961 - 2968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Wands, C. L. Roark, M. K. Aydintug, N. Jin, Y.-S. Hahn, L. Cook, X. Yin, J. Dal Porto, M. Lahn, D. M. Hyde, et al. Distribution and leukocyte contacts of {gamma}{delta} T cells in the lung J. Leukoc. Biol., November 1, 2005; 78(5): 1086 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jin, C. Taube, L. Sharp, Y.-S. Hahn, X. Yin, J. M. Wands, C. L. Roark, R. L. O'Brien, E. W. Gelfand, and W. K. Born Mismatched Antigen Prepares {gamma}{delta} T Cells for Suppression of Airway Hyperresponsiveness J. Immunol., March 1, 2005; 174(5): 2671 - 2679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-S. Hahn, C. Taube, N. Jin, L. Sharp, J. M. Wands, M. K. Aydintug, M. Lahn, S. A. Huber, R. L. O'Brien, E. W. Gelfand, et al. Different Potentials of {gamma}{delta} T Cell Subsets in Regulating Airway Responsiveness: V{gamma}1+ Cells, but Not V{gamma}4+ Cells, Promote Airway Hyperreactivity, Th2 Cytokines, and Airway Inflammation J. Immunol., March 1, 2004; 172(5): 2894 - 2902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-H. Cui, A. Joetham, M. K. Aydintug, Y.-S. Hahn, W. K. Born, and E. W. Gelfand Reversal of Allergic Airway Hyperreactivity after Long-term Allergen Challenge Depends on {gamma}{delta} T Cells Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1324 - 1332. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
