| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
,,
Departments of
*
Medicine and
Pathology and Laboratory Medicine,
Institute for Medicine and Engineering,
The Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104; and
¶ Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115
Notch receptors signal through a highly conserved pathway to influence cell fate decisions. Notch1 is required for T lineage commitment; however, a role for Notch signaling has not been clearly defined for the peripheral T cell response. Notch gene expression is induced, and Notch1 is activated in primary CD4+ T cells following specific peptide-Ag stimulation. Notch activity contributes to the peripheral T cell response, as inhibition of endogenous Notch activation decreases the proliferation of activated T cells in a manner associated with the diminished production of IL-2 and the expression of the high affinity IL-2R (CD25). Conversely, forced expression of a constitutively active Notch1 in primary T cells results in increased surface expression of CD25, and renders these cells more sensitive to both cognate Ag and IL-2, as measured by cell division. These data suggest an important role for Notch signaling during CD4+ T cell responses, which operates through augmenting a positive feedback loop involving IL-2 and its high affinity receptor.
This article has been cited by other articles:
|
|
 |
|
  K. Laky, W. Annaert, and B. J. Fowlkes Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development Int. Immunol., October 1, 2009; 21(10): 1163 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Okamoto, H. Matsuda, A. Joetham, J. J. Lucas, J. Domenico, K. Yasutomo, K. Takeda, and E. W. Gelfand Jagged1 on Dendritic Cells and Notch on CD4+ T Cells Initiate Lung Allergic Responsiveness by Inducing IL-4 Production J. Immunol., September 1, 2009; 183(5): 2995 - 3003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. H. Cho, H. M. Shin, L. Miele, T. E. Golde, A. Fauq, L. M. Minter, and B. A. Osborne Notch Regulates Cytolytic Effector Function in CD8+ T Cells J. Immunol., March 15, 2009; 182(6): 3380 - 3389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Scheinman and O. Avni Transcriptional Regulation of Gata3 in T Helper Cells by the Integrated Activities of Transcription Factors Downstream of the Interleukin-4 Receptor and T Cell Receptor J. Biol. Chem., January 30, 2009; 284(5): 3037 - 3048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chari and S. Winandy Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes J. Immunol., November 1, 2008; 181(9): 6265 - 6274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Guo, I. Maillard, S. Chakraborti, E. V. Rothenberg, and N. A. Speck Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification Blood, August 1, 2008; 112(3): 480 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Krawczyk, J. Sun, and E. J. Pearce Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells J. Immunol., June 15, 2008; 180(12): 7931 - 7937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Okamoto, K. Takeda, A. Joetham, H. Ohnishi, H. Matsuda, C. H. Swasey, B. J. Swanson, K. Yasutomo, A. Dakhama, and E. W. Gelfand Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation J. Exp. Med., May 12, 2008; 205(5): 1087 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rutz, M. Janke, N. Kassner, T. Hohnstein, M. Krueger, and A. Scheffold Notch regulates IL-10 production by T helper 1 cells PNAS, March 4, 2008; 105(9): 3497 - 3502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Asano, T. Watanabe, A. Kitani, I. J. Fuss, and W. Strober Notch1 Signaling and Regulatory T Cell Function J. Immunol., March 1, 2008; 180(5): 2796 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jurynczyk, A. Jurewicz, C. S. Raine, and K. Selmaj Notch3 Inhibition in Myelin-Reactive T Cells Down-Regulates Protein Kinase C{theta} and Attenuates Experimental Autoimmune Encephalomyelitis J. Immunol., February 15, 2008; 180(4): 2634 - 2640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, C. J. Krawczyk, and E. J. Pearce Suppression of Th2 Cell Development by Notch Ligands Delta1 and Delta4 J. Immunol., February 1, 2008; 180(3): 1655 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Teachey, A. E. Seif, V. I. Brown, M. Bruno, R. M. Bunte, Y. J. Chang, J. K. Choi, J. D. Fish, J. Hall, G. S. Reid, et al. Targeting Notch signaling in autoimmune and lymphoproliferative disease Blood, January 15, 2008; 111(2): 705 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Michie, A. C. Chan, M. Ciofani, M. Carleton, J. M. Lefebvre, Y. He, D. M. Allman, D. L. Wiest, J. C. Zuniga-Pflucker, and D. J. Izon Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals Int. Immunol., December 1, 2007; 19(12): 1421 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Elyaman, E. M. Bradshaw, Y. Wang, M. Oukka, P. Kivisakk, S. Chiba, H. Yagita, and S. J. Khoury Jagged1 and Delta1 Differentially Regulate the Outcome of Experimental Autoimmune Encephalomyelitis J. Immunol., November 1, 2007; 179(9): 5990 - 5998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Laky and B.J. Fowlkes Presenilins regulate {alpha}{beta} T cell development by modulating TCR signaling J. Exp. Med., September 3, 2007; 204(9): 2115 - 2129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Munroe and G. A. Bishop A Costimulatory Function for T Cell CD40 J. Immunol., January 15, 2007; 178(2): 671 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Sharma, J. A. Calvo, K. M. Draheim, L. A. Cunningham, N. Hermance, L. Beverly, V. Krishnamoorthy, M. Bhasin, A. J. Capobianco, and M. A. Kelliher Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc Mol. Cell. Biol., November 1, 2006; 26(21): 8022 - 8031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bheeshmachar, D. Purushotaman, H. Sade, V. Gunasekharan, A. Rangarajan, and A. Sarin Evidence for a Role for Notch Signaling in the Cytokine-Dependent Survival of Activated T Cells J. Immunol., October 15, 2006; 177(8): 5041 - 5050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pejawar-Gaddy and M. A. Alexander-Miller Ligation of CD80 Is Critical for High-Level CD25 Expression on CD8+ T Lymphocytes J. Immunol., October 1, 2006; 177(7): 4495 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Stallwood, E. Briend, K. M. Ray, G. A. Ward, B. J. Smith, E. Nye, B. R. Champion, and G. J. McKenzie Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4+ T Cells and Dendritic Cells Enhances Cytokine Production J. Immunol., July 15, 2006; 177(2): 885 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Monsalve, M. A. Perez, A. Rubio, M. J. Ruiz-Hidalgo, V. Baladron, J. J. Garcia-Ramirez, J. C. Gomez, J. Laborda, and M. J. M. Diaz-Guerra Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity J. Immunol., May 1, 2006; 176(9): 5362 - 5373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dumortier, R. Jeannet, P. Kirstetter, E. Kleinmann, M. Sellars, N. R. dos Santos, C. Thibault, J. Barths, J. Ghysdael, J. A. Punt, et al. Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice Mol. Cell. Biol., January 1, 2006; 26(1): 209 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tu, T. C. Fang, D. Artis, O. Shestova, S. E. Pross, I. Maillard, and W. S. Pear Notch signaling is an important regulator of type 2 immunity J. Exp. Med., October 17, 2005; 202(8): 1037 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. de La Coste, E. Six, N. Fazilleau, L. Mascarell, N. Legrand, M.-P. Mailhe, A. Cumano, Y. Laabi, and A. A. Freitas In Vivo and in Absence of a Thymus, the Enforced Expression of the Notch Ligands Delta-1 or Delta-4 Promotes T Cell Development with Specific Unique Effects J. Immunol., March 1, 2005; 174(5): 2730 - 2737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Anderson, E. A. Kitchens, S. W. Chan, C. St. Hill, Y. N. Jan, W. Zhong, and E. A. Robey The Notch Regulator Numb Links the Notch and TCR Signaling Pathways J. Immunol., January 15, 2005; 174(2): 890 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Tsukumo and K. Yasutomo Notch Governing Mature T Cell Differentiation J. Immunol., December 15, 2004; 173(12): 7109 - 7113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Puthier, F. Joly, M. Irla, M. Saade, G. Victorero, B. Loriod, and C. Nguyen A General Survey of Thymocyte Differentiation by Transcriptional Analysis of Knockout Mouse Models J. Immunol., November 15, 2004; 173(10): 6109 - 6118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Back, A. Dierich, C. Bronn, P. Kastner, and S. Chan PU.1 determines the self-renewal capacity of erythroid progenitor cells Blood, May 15, 2004; 103(10): 3615 - 3623. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
