| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia;
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
La Jolla Institute for Allergy and Immunology, San Diego, CA 92121;
Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia;
¶ Centenary Institute, Sydney, Australia; and
|| Comparative Genomics Centre, James Cook University, Townsville, Australia
Natural killer T cells are an immunoregulatory population of lymphocytes that plays a critical role in controlling the adaptive immune system and contributes to the regulation of autoimmune responses. We have previously reported deficiencies in the numbers and function of NKT cells in the nonobese diabetic (NOD) mouse strain, a well-validated model of type 1 diabetes and systemic lupus erythematosus. In this study, we report the results of a genetic linkage analysis of the genes controlling NKT cell numbers in a first backcross (BC1) from C57BL/6 to NOD.Nkrp1b mice. The numbers of thymic NKT cells of 320 BC1 mice were determined by fluorescence-activated cell analysis using anti-TCR Ab and CD1/
-galactosylceramide tetramer. Tail DNA of 138 female BC1 mice was analyzed for PCR product length polymorphisms at 181 simple sequence repeats, providing greater than 90% coverage of the autosomal genome with an average marker separation of 8 cM. Two loci exhibiting significant linkage to NKT cell numbers were identified; the most significant (Nkt1) was on distal chromosome 1, in the same region as the NOD mouse lupus susceptibility gene Babs2/Bana3. The second most significant locus (Nkt2) mapped to the same region as Idd13, a NOD-derived diabetes susceptibility gene on chromosome 2.
This article has been cited by other articles:
|
|
 |
|
  J. M. Fletcher, M. A. Jordan, S. L. Snelgrove, R. M. Slattery, F. D. Dufour, K. Kyparissoudis, G. S. Besra, D. I. Godfrey, and A. G. Baxter Congenic Analysis of the NKT Cell Control Gene Nkt2 Implicates the Peroxisomal Protein Pxmp4 J. Immunol., September 1, 2008; 181(5): 3400 - 3412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vallois, M.-C. Gagnerault, P. Avner, U. C. Rogner, C. Boitard, K. Benlagha, A. Herbelin, and F. Lepault Influence of a Non-NK Complex Region of Chromosome 6 on CD4+ Invariant NK T Cell Homeostasis J. Immunol., August 1, 2008; 181(3): 1753 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Jordan, J. M. Fletcher, D. Pellicci, and A. G. Baxter Slamf1, the NKT Cell Control Gene Nkt1 J. Immunol., February 1, 2007; 178(3): 1618 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-C. Rocha-Campos, R. Melki, R. Zhu, N. Deruytter, D. Damotte, M. Dy, A. Herbelin, and H.-J. Garchon Genetic and Functional Analysis of the Nkt1 Locus Using Congenic NOD Mice: Improved V{alpha}14-NKT Cell Performance but Failure to Protect Against Type 1 Diabetes. Diabetes, April 1, 2006; 55(4): 1163 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lundholm, V. Motta, A. Lofgren-Burstrom, N. Duarte, M.-L. Bergman, S. Mayans, and D. Holmberg Defective Induction of CTLA-4 in the NOD Mouse Is Controlled by the NOD Allele of Idd3/IL-2 and a Novel Locus (Ctex) Telomeric on Chromosome 1 Diabetes, February 1, 2006; 55(2): 538 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Brodnicki, A. L. Fletcher, D. G. Pellicci, S. P. Berzins, P. McClive, F. Quirk, K. E. Webster, H. S. Scott, R. L. Boyd, D. I. Godfrey, et al. Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice Diabetes, December 1, 2005; 54(12): 3453 - 3457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Wei, H. Lee, S.-H. Park, L. Beaudoin, L. Teyton, A. Lehuen, and A. Bendelac Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes J. Exp. Med., July 18, 2005; 202(2): 239 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rolf, V. Motta, N. Duarte, M. Lundholm, E. Berntman, M.-L. Bergman, L. Sorokin, S. L. Cardell, and D. Holmberg The Enlarged Population of Marginal Zone/CD1dhigh B Lymphocytes in Nonobese Diabetic Mice Maps to Diabetes Susceptibility Region Idd11 J. Immunol., April 15, 2005; 174(8): 4821 - 4827. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
