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Regulation of the Human High Affinity IgE Receptor -Chain Gene Expression Via an Intronic Element

Kyoko Takahashi^*, Chiharu Nishiyama, Masanari Hasegawa, Yushiro Akizawa and Chisei Ra^1,*

^* Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, Tokyo, Japan; Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan; Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan; and Taiho Pharmaceutical Co. Ltd., Saitama, Japan

The high affinity IgE receptor, FcRI, is a key regulatory molecule in the allergic reaction. By screening for cis-acting elements over the entire region of the human FcRI -chain gene, a sequence located in the fourth intron was revealed to serve as a repressor element. This element was recognized by a transcription factor, myeloid zinc finger protein 1 (MZF-1). Introduction of MZF-1 antisense inhibited the suppressive effect of the element on the -chain promoter and increased the mRNA for the -chain in KU812 cells, indicating that MZF-1 repressed human FcRI -chain gene expression via the element in the fourth intron. Furthermore, it was suggested that a cofactor binding with MZF-1, whose expression level was different among the cell types, was required for transcriptional repression by MZF-1.

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