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The Journal of Immunology, 2003, 171: 2453-2460.
Copyright © 2003 by The American Association of Immunologists

Adenoviral Infection Decreases Mortality from Lipopolysaccharide-Induced Liver Failure Via Induction of TNF-{alpha} Tolerance 1

Timur O. Yarovinsky2, Linda S. Powers, Noah S. Butler, Mary A. Bradford, Martha M. Monick and Gary W. Hunninghake

Department of Internal Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa and Veteran Affairs Medical Center, Iowa City, IA 52242

Effects of adenoviral infection on in vivo responses to LPS mediated by TNF-{alpha} were evaluated in a murine model. Adenovirus-infected mice showed decreased mortality from fulminant hepatitis induced by administration of LPS or staphylococcal enterotoxin B in the presence of D-galactosamine. Importantly, TNF-{alpha} resistance genes within adenoviral E3 region were not required, because E1,E3-deleted vectors showed similar effects. Adenovirus-infected mice exhibited higher TNF-{alpha} levels after LPS stimulation, no difference in TNFR1 expression, and similar mortality from Fas-induced fulminant hepatitis. Decreased production of IL-6 and KC in response to exogenous TNF-{alpha}, in addition to protection from TNF-{alpha}, suggested that adenoviral infection results in TNF-{alpha} tolerance.




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