HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bayley, J.-P. Articles by Verweij, C. L. Search for Related Content PubMed PubMed Citation Articles by Bayley, J.-P. Articles by Verweij, C. L. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Genetics Home Reference

Allele-Specific Expression of the IL-1 Gene in Human CD4⁺ T Cell Clones ¹

Jean-Pierre Bayley^*, Johanna G. I. van Rietschoten, Aleida M. Bakker^*, Lisa van Baarsen, Eric L. Kaijzel, Eddy A. Wierenga, Tineke C. T. M. van der Pouw Kraan, Tom W. J. Huizinga^* and Cornelis L. Verweij^2,

^* Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands; Toegepast Natuurwetenschappelk Onderzoek Prevention and Health, Leiden, The Netherlands; and Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

A number of reports have described the monoallelic expression of murine cytokine genes. Here we describe the monoallelic expression of the human IL-1 gene in CD4⁺ T cells. Analysis of peripheral blood T cell clones derived from healthy individuals revealed that the IL-1 gene shows predominantly monoallelic expression. Monoallelic expression was observed in Th0, Th1, and Th2 cell clones. In addition, we demonstrate monoallelic expression in T cell clones from rheumatoid arthritis patients derived from synovial fluid of the knee joint, suggesting that the occurrence of this phenomenon is not different from that in clones derived from healthy individuals. The finding of monoallelic expression of a cytokine gene in human CD4⁺ T cell clones provides evidence for allele-specific silencing/activation as another layer of regulation of IL-1 gene expression.

This article has been cited by other articles:

				D. P. Calado, T. Paixao, D. Holmberg, and M. Haury Stochastic Monoallelic Expression of IL-10 in T Cells J. Immunol., October 15, 2006; 177(8): 5358 - 5364. [Abstract] [Full Text] [PDF]

				J. G. I. van Rietschoten, K. F. Verzijlbergen, S. I. Gringhuis, T. C. T. M. v. d. P. Kraan, J.-P. Bayley, E. A. Wierenga, P. A. Jones, J. M. Kooter, and C. L. Verweij Differentially methylated alleles in a distinct region of the human interleukin-1{alpha} promoter are associated with allele-specific expression of IL-1{alpha} in CD4+ T cells Blood, October 1, 2006; 108(7): 2143 - 2149. [Abstract] [Full Text] [PDF]