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The Journal of Immunology, 2003, 171: 1978-1983.
Copyright © 2003 by The American Association of Immunologists

The Fourth Surface-Exposed Region of the Outer Membrane Protein P5-Homologous Adhesin of Nontypable Haemophilus influenzae Is an Immunodominant But Nonprotective Decoying Epitope1

Laura A. Novotny and Lauren O. Bakaletz2

Division of Molecular Medicine, Department of Pediatrics, Columbus Children’s Research Institute, Ohio State University College of Medicine and Public Health, Columbus, OH 43205

Nontypable Haemophilus influenzae is a major cause of otitis media and other mucosal infections. After natural disease in children and experimental disease in chinchillas, we found a hierarchical pattern of immunodominance among the four surface-exposed regions of the P5-homologous adhesin, with the greatest response directed to region 4. However, Ab to region 4 is not protective. When this natural but biased response was refocused to region 3 by immunization, augmented bacterial clearance and protection from ascending otitis media was observed. Collectively, the data indicate that region 4 contains a highly immunodominant but nonprotective decoying epitope, the presence of which dampens the immune response to a subdominant but protective epitope in region 3.




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Genomic Sequence of an Otitis Media Isolate of Nontypeable Haemophilus influenzae: Comparative Study with H. influenzae Serotype d, Strain KW20
J. Bacteriol., July 1, 2005; 187(13): 4627 - 4636.
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