HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Novotny, L. A. Articles by Bakaletz, L. O. Search for Related Content PubMed PubMed Citation Articles by Novotny, L. A. Articles by Bakaletz, L. O.

The Fourth Surface-Exposed Region of the Outer Membrane Protein P5-Homologous Adhesin of Nontypable Haemophilus influenzae Is an Immunodominant But Nonprotective Decoying Epitope¹

Division of Molecular Medicine, Department of Pediatrics, Columbus Children’s Research Institute, Ohio State University College of Medicine and Public Health, Columbus, OH 43205

Nontypable Haemophilus influenzae is a major cause of otitis media and other mucosal infections. After natural disease in children and experimental disease in chinchillas, we found a hierarchical pattern of immunodominance among the four surface-exposed regions of the P5-homologous adhesin, with the greatest response directed to region 4. However, Ab to region 4 is not protective. When this natural but biased response was refocused to region 3 by immunization, augmented bacterial clearance and protection from ascending otitis media was observed. Collectively, the data indicate that region 4 contains a highly immunodominant but nonprotective decoying epitope, the presence of which dampens the immune response to a subdominant but protective epitope in region 3.

This article has been cited by other articles:

				M. A. Mullins, K. B. Register, D. O. Bayles, C. L. Loving, T. L. Nicholson, S. L. Brockmeier, D. W. Dyer, and G. J. Phillips Characterization and Comparative Analysis of the Genes Encoding Haemophilus parasuis Outer Membrane Proteins P2 and P5 J. Bacteriol., October 1, 2009; 191(19): 5988 - 6002. [Abstract] [Full Text] [PDF]

				J. M. Schwingel, K. J. Edwards, A. D. Cox, H. Masoud, J. C. Richards, F. St. Michael, C. D. Tekwe, S. Sethi, T. F. Murphy, and A. A. Campagnari Use of Moraxella catarrhalis Lipooligosaccharide Mutants To Identify Specific Oligosaccharide Epitopes Recognized by Human Serum Antibodies Infect. Immun., October 1, 2009; 77(10): 4548 - 4558. [Abstract] [Full Text] [PDF]

				A. Harrison, D. W. Dyer, A. Gillaspy, W. C. Ray, R. Mungur, M. B. Carson, H. Zhong, J. Gipson, M. Gipson, L. S. Johnson, et al. Genomic Sequence of an Otitis Media Isolate of Nontypeable Haemophilus influenzae: Comparative Study with H. influenzae Serotype d, Strain KW20 J. Bacteriol., July 1, 2005; 187(13): 4627 - 4636. [Abstract] [Full Text] [PDF]