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The Journal of Immunology, 2003, 171: 1148-1155.
Copyright © 2003 by The American Association of Immunologists

Macrophages of the Splenic Marginal Zone Are Essential for Trapping of Blood-Borne Particulate Antigen but Dispensable for Induction of Specific T Cell Responses

Peter Aichele*,{dagger}, Jana Zinke*, Leander Grode*, Reto A. Schwendener{dagger},{ddagger}, Stefan H. E. Kaufmann1,* and Peter Seiler2,*

* Abteilung Immunologie, Max-Planck-Institut für Infektionsbiologie, Berlin, Germany; {dagger} Institut fur Medizinische Mikrobiologie Hygiene, Universitatsklinikum Freiburg, Freiburg, Germany; and {ddagger} Paul Scherrer Institute, Villingen, Switzerland

Rapid removal of pathogens from the circulation by secondary lymphoid organs is prerequisite for successful control of infection. Blood-borne Ags are trapped mainly in the splenic marginal zone. To identify the cell populations responsible for Ag trapping in the marginal zone, mice were selectively depleted of marginal zone macrophages and marginal metallophilic macrophages. In the absence of these cells, trapping of microspheres and Listeria monocytogenes organisms was lost, and early control of infection was impaired. Depletion of marginal zone macrophages and marginal metallophilic macrophages, however, did not limit Ag presentation because Listeria-specific protective T cell immunity was induced. Therefore, marginal zone macrophages and marginal metallophilic macrophages are crucial for trapping of particulate Ag but dispensable for Ag presentation.




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