The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brown, C. R.
Right arrow Articles by Loiacono, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, C. R.
Right arrow Articles by Loiacono, C. M.
The Journal of Immunology, 2003, 171: 893-901.
Copyright © 2003 by The American Association of Immunologists

Susceptibility to Experimental Lyme Arthritis Correlates with KC and Monocyte Chemoattractant Protein-1 Production in Joints and Requires Neutrophil Recruitment Via CXCR21

Charles R. Brown2,*,{dagger}, Victoria A. Blaho* and Christie M. Loiacono{dagger}

Departments of * Molecular Microbiology and Immunology and {dagger} Veterinary Pathobiology, University of Missouri, Columbia, MO 65211

The development of experimental Lyme arthritis has been correlated with the expression of a number of chemokines and cytokines, however, none of these have been measured directly from the arthritic joint. We examined the temporal expression of IL-1{beta}, IL-4, IL-6, IL-10, IL-12p70, GM-CSF, IFN-{gamma}, TNF-{alpha}, macrophage inflammatory protein-2, KC, macrophage inflammatory protein-1{alpha}, and monocyte chemoattractant protein-1 directly from the tibiotarsal joint in arthritis-resistant C57BL/6 (B6) and -susceptible C3H/He (C3H) mice. Only the chemokines KC and monocyte chemoattractant protein-1 were differentially expressed in joints of B6 and C3H mice and correlated with the development of Lyme arthritis. Infection of CXCR2-/- mice on either genetic background resulted in a significant decrease in the development of pathology, although infection of CCR2-/- mice had little or no effect. Neutrophils in CXCR2-/- mice were marginalized within blood vessels and could not enter the joint tissue. These results suggest that chemokine-mediated recruitment of neutrophils into the infected joint is a key requirement for the development of experimental Lyme arthritis.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
G. Wang, M. M. Petzke, R. Iyer, H. Wu, and I. Schwartz
Pattern of Proinflammatory Cytokine Induction in RAW264.7 Mouse Macrophages Is Identical for Virulent and Attenuated Borrelia burgdorferi
J. Immunol., June 15, 2008; 180(12): 8306 - 8315.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
D. T. Nardelli, S. M. Callister, and R. F. Schell
Lyme Arthritis: Current Concepts and a Change in Paradigm
Clin. Vaccine Immunol., January 1, 2008; 15(1): 21 - 34.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. R. Mullegger, T. K. Means, J. J. Shin, M. Lee, K. L. Jones, L. J. Glickstein, A. D. Luster, and A. C. Steere
Chemokine Signatures in the Skin Disorders of Lyme Borreliosis in Europe: Predominance of CXCL9 and CXCL10 in Erythema Migrans and Acrodermatitis and CXCL13 in Lymphocytoma
Infect. Immun., September 1, 2007; 75(9): 4621 - 4628.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Q. Xu, S. V. Seemanapalli, K. E. Reif, C. R. Brown, and F. T. Liang
Increasing the Recruitment of Neutrophils to the Site of Infection Dramatically Attenuates Borrelia burgdorferi Infectivity
J. Immunol., April 15, 2007; 178(8): 5109 - 5115.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
T.A. Silva, G.P. Garlet, S.Y. Fukada, J.S. Silva, and F.Q. Cunha
Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease
J. Dent. Res., April 1, 2007; 86(4): 306 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. S. Di Genaro, D. E. Cargnelutti, J. R. Elicabe, M. G. Lacoste, S. Valdez, N. Gomez, and A. M. S. de Guzman
Role of TNFRp55 in Yersinia enterocolitica O:3-induced arthritis: triggering bacterial antigens and articular immune response
Rheumatology, April 1, 2007; 46(4): 590 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. R. Montgomery, C. J. Booth, X. Wang, V. A. Blaho, S. E. Malawista, and C. R. Brown
Recruitment of Macrophages and Polymorphonuclear Leukocytes in Lyme Carditis
Infect. Immun., February 1, 2007; 75(2): 613 - 620.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. M. Dame, B. L. Orenzoff, L. E. Palmer, and M. B. Furie
IFN-{gamma} Alters the Response of Borrelia burgdorferi-Activated Endothelium to Favor Chronic Inflammation
J. Immunol., January 15, 2007; 178(2): 1172 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Khan, N. Cole, E. B. Hume, L. Garthwaite, T. C. R. Conibear, D. H. Miles, Y. Aliwaga, M. B. Krockenberger, and M. D. P. Willcox
The role of CXC chemokine receptor 2 in Pseudomonas aeruginosa corneal infection
J. Leukoc. Biol., January 1, 2007; 81(1): 315 - 318.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Crandall, D. M. Dunn, Y. Ma, R. M. Wooten, J. F. Zachary, J. H. Weis, R. B. Weiss, and J. J. Weis
Gene Expression Profiling Reveals Unique Pathways Associated with Differential Severity of Lyme Arthritis
J. Immunol., December 1, 2006; 177(11): 7930 - 7942.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. J. Lazarus, M. J. Meadows, R. E. Lintner, and R. M. Wooten
IL-10 Deficiency Promotes Increased Borrelia burgdorferi Clearance Predominantly through Enhanced Innate Immune Responses
J. Immunol., November 15, 2006; 177(10): 7076 - 7085.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. P. de Lema, H. Maier, T. J. Franz, M. Escribese, S. Chilla, S. Segerer, N. Camarasa, H. Schmid, B. Banas, S. Kalaydjiev, et al.
Chemokine Receptor Ccr2 Deficiency Reduces Renal Disease and Prolongs Survival in MRL/lpr Lupus-Prone Mice
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3592 - 3601.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Guerau-de-Arellano, J. Alroy, D. Bullard, and B. T. Huber
Aggravated Lyme Carditis in CD11a-/- and CD11c-/- Mice
Infect. Immun., November 1, 2005; 73(11): 7637 - 7643.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Glasner, H. Blum, V. Wehner, H. U. Stilz, J. D. Humphries, G. P. Curley, A. P. Mould, M. J. Humphries, R. Hallmann, M. Rollinghoff, et al.
A Small Molecule {alpha}4{beta}1 Antagonist Prevents Development of Murine Lyme Arthritis without Affecting Protective Immunity
J. Immunol., October 1, 2005; 175(7): 4724 - 4734.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Iyoda, K. Nagata, M. Akashi, and Y. Kobayashi
Neutrophils Accelerate Macrophage-Mediated Digestion of Apoptotic Cells In Vivo as Well as In Vitro
J. Immunol., September 15, 2005; 175(6): 3475 - 3483.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. Chen, Y. Wei, A. Alter, G. C. Sharp, and H. Braley-Mullen
Chemokine expression during development of fibrosis versus resolution in a murine model of granulomatous experimental autoimmune thyroiditis
J. Leukoc. Biol., September 1, 2005; 78(3): 716 - 724.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Crandall, Y. Ma, D. M. Dunn, R. S. Sundsbak, J. F. Zachary, P. Olofsson, R. Holmdahl, J. H. Weis, R. B. Weiss, C. Teuscher, et al.
Bb2Bb3 Regulation of Murine Lyme Arthritis Is Distinct from Ncf1 and Independent of the Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase
Am. J. Pathol., September 1, 2005; 167(3): 775 - 785.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Guerau-de-Arellano, J. Alroy, and B. T. Huber
{beta}2 Integrins Control the Severity of Murine Lyme Carditis
Infect. Immun., June 1, 2005; 73(6): 3242 - 3250.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. R.-E.-I. Benhnia, D. Wroblewski, M. N. Akhtar, R. A. Patel, W. Lavezzi, S. C. Gangloff, S. M. Goyert, M. J. Caimano, J. D. Radolf, and T. J. Sellati
Signaling through CD14 Attenuates the Inflammatory Response to Borrelia burgdorferi, the Agent of Lyme Disease
J. Immunol., February 1, 2005; 174(3): 1539 - 1548.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Ray, D. Kumar, A. Shakya, C. R. Brown, J. L. Cook, and B. K. Ray
Serum Amyloid A-Activating Factor-1 (SAF-1) Transgenic Mice Are Prone to Develop a Severe Form of Inflammation-Induced Arthritis
J. Immunol., October 1, 2004; 173(7): 4684 - 4691.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. R. Brown, V. A. Blaho, and C. M. Loiacono
Treatment of Mice with the Neutrophil-Depleting Antibody RB6-8C5 Results in Early Development of Experimental Lyme Arthritis via the Recruitment of Gr-1- Polymorphonuclear Leukocyte-Like Cells
Infect. Immun., September 1, 2004; 72(9): 4956 - 4965.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. L. Galindo, A. A. Fadl, J. Sha, and A. K. Chopra
Microarray Analysis of Aeromonas hydrophila Cytotoxic Enterotoxin-Treated Murine Primary Macrophages
Infect. Immun., September 1, 2004; 72(9): 5439 - 5445.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. D. Bolz, R. S. Sundsbak, Y. Ma, S. Akira, C. J. Kirschning, J. F. Zachary, J. H. Weis, and J. J. Weis
MyD88 Plays a Unique Role in Host Defense but Not Arthritis Development in Lyme Disease
J. Immunol., August 1, 2004; 173(3): 2003 - 2010.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. L. Lomas-Neira, C.-S. Chung, P. S. Grutkoski, E. J. Miller, and A. Ayala
CXCR2 inhibition suppresses hemorrhage-induced priming for acute lung injury in mice
J. Leukoc. Biol., July 1, 2004; 76(1): 58 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Liu, R. R. Montgomery, S. W. Barthold, and L. K. Bockenstedt
Myeloid Differentiation Antigen 88 Deficiency Impairs Pathogen Clearance but Does Not Alter Inflammation in Borrelia burgdorferi-Infected Mice
Infect. Immun., June 1, 2004; 72(6): 3195 - 3203.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. I. Medeiros, A. Sa-Nunes, E. G. Soares, C. M. Peres, C. L. Silva, and L. H. Faccioli
Blockade of Endogenous Leukotrienes Exacerbates Pulmonary Histoplasmosis
Infect. Immun., March 1, 2004; 72(3): 1637 - 1644.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.