The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van der Velden, A. W. M.
Right arrow Articles by Starnbach, M. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van der Velden, A. W. M.
Right arrow Articles by Starnbach, M. N.
The Journal of Immunology, 2003, 171: 6742-6749.
Copyright © 2003 by The American Association of Immunologists

Salmonella Rapidly Kill Dendritic Cells via a Caspase-1- Dependent Mechanism1

Adrianus W. M. van der Velden, Marisela Velasquez and Michael N. Starnbach2

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115

Dendritic cells provide a critical link between innate and acquired immunity. In this study, we demonstrate that the bacterial pathogen Salmonella enterica serovar Typhimurium can efficiently kill these professional phagocytes via a mechanism that is dependent on sipB and the Salmonella pathogenicity island 1-encoded type III protein secretion system. Rapid phosphatidylserine redistribution, caspase activation, and loss of plasma membrane integrity were characteristic of dendritic cells infected with wild-type Salmonella, but not sipB mutant bacteria. Caspase-1 was particularly important in this process because Salmonella-induced dendritic cell death was dramatically reduced in the presence of a caspase-1-specific inhibitor. Furthermore, dendritic cells obtained from caspase-1-deficient mice, but not heterozygous littermate control mice, were resistant to Salmonella-induced cytotoxicity. We hypothesize that Salmonella have evolved the ability to selectively kill professional APCs to combat, exploit, or evade immune defense mechanisms.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. W. M. van der Velden, J. T. Dougherty, and M. N. Starnbach
Down-Modulation of TCR Expression by Salmonella enterica serovar Typhimurium
J. Immunol., April 15, 2008; 180(8): 5569 - 5574.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. L. Fink, T. Bergsbaken, and B. T. Cookson
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
PNAS, March 18, 2008; 105(11): 4312 - 4317.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. C. Alaniz, B. L. Deatherage, J. C. Lara, and B. T. Cookson
Membrane Vesicles Are Immunogenic Facsimiles of Salmonella typhimurium That Potently Activate Dendritic Cells, Prime B and T Cell Responses, and Stimulate Protective Immunity In Vivo
J. Immunol., December 1, 2007; 179(11): 7692 - 7701.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-H. Sun, H. G. Rolan, and R. M. Tsolis
Injection of Flagellin into the Host Cell Cytosol by Salmonella enterica Serotype Typhimurium
J. Biol. Chem., November 23, 2007; 282(47): 33897 - 33901.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Ravindran, L. Rusch, A. Itano, M. K. Jenkins, and S. J. McSorley
CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection
PNAS, July 17, 2007; 104(29): 12075 - 12080.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
A. Guo, M. A. Lasaro, J.-C. Sirard, J.-P. Kraehenbuhl, and D. M. Schifferli
Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells
Microbiology, April 1, 2007; 153(4): 1059 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. A. Tobar, L. J. Carreno, S. M. Bueno, P. A. Gonzalez, J. E. Mora, S. A. Quezada, and A. M. Kalergis
Virulent Salmonella enterica Serovar Typhimurium Evades Adaptive Immunity by Preventing Dendritic Cells from Activating T Cells.
Infect. Immun., November 1, 2006; 74(11): 6438 - 6448.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Sarkar, M. W. Hall, M. Exline, J. Hart, N. Knatz, N. T. Gatson, and M. D. Wewers
Caspase-1 Regulates Escherichia coli Sepsis and Splenic B Cell Apoptosis Independently of Interleukin-1beta and Interleukin-18
Am. J. Respir. Crit. Care Med., November 1, 2006; 174(9): 1003 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Raupach, S.-K. Peuschel, D. M. Monack, and A. Zychlinsky
Caspase-1-Mediated Activation of Interleukin-1{beta} (IL-1{beta}) and IL-18 Contributes to Innate Immune Defenses against Salmonella enterica Serovar Typhimurium Infection.
Infect. Immun., August 1, 2006; 74(8): 4922 - 4926.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Pei, J. E. Turse, Q. Wu, and T. A. Ficht
Brucella abortus Rough Mutants Induce Macrophage Oncosis That Requires Bacterial Protein Synthesis and Direct Interaction with the Macrophage.
Infect. Immun., May 1, 2006; 74(5): 2667 - 2675.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. Hu, M. D. Bray, M. Osorio, and D. J. Kopecko
Campylobacter jejuni Induces Maturation and Cytokine Production in Human Dendritic Cells.
Infect. Immun., May 1, 2006; 74(5): 2697 - 2705.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. W. M. van der Velden, M. K. Copass, and M. N. Starnbach
Salmonella inhibit T cell proliferation by a direct, contact-dependent immunosuppressive effect
PNAS, December 6, 2005; 102(49): 17769 - 17774.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Sha, L. Pillai, A. A. Fadl, C. L. Galindo, T. E. Erova, and A. K. Chopra
The Type III Secretion System and Cytotoxic Enterotoxin Alter the Virulence of Aeromonas hydrophila
Infect. Immun., October 1, 2005; 73(10): 6446 - 6457.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. E. Pietila, V. Veckman, P. Kyllonen, K. Lahteenmaki, T. K. Korhonen, and I. Julkunen
Activation, cytokine production, and intracellular survival of bacteria in Salmonella-infected human monocyte-derived macrophages and dendritic cells
J. Leukoc. Biol., October 1, 2005; 78(4): 909 - 920.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Valle and D. G. Guiney
Characterization of Salmonella-Induced Cell Death in Human Macrophage-Like THP-1 Cells
Infect. Immun., May 1, 2005; 73(5): 2835 - 2840.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. A. Knodler, B. B. Finlay, and O. Steele-Mortimer
The Salmonella Effector Protein SopB Protects Epithelial Cells from Apoptosis by Sustained Activation of Akt
J. Biol. Chem., March 11, 2005; 280(10): 9058 - 9064.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Hapfelmeier, B. Stecher, M. Barthel, M. Kremer, A. J. Muller, M. Heikenwalder, T. Stallmach, M. Hensel, K. Pfeffer, S. Akira, et al.
The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms
J. Immunol., February 1, 2005; 174(3): 1675 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Tobar, P. A. Gonzalez, and A. M. Kalergis
Salmonella Escape from Antigen Presentation Can Be Overcome by Targeting Bacteria to Fc{gamma} Receptors on Dendritic Cells
J. Immunol., September 15, 2004; 173(6): 4058 - 4065.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.