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The Selection of Marginal Zone B Cells Differs from That of B-1a Cells ¹

Karsten Kretschmer^2,*, Anke Jungebloud^*, Jana Stopkowicz^*, Tanja Kleinke^*, Reinhard Hoffmann^3, and Siegfried Weiss^*

^* Molecular Immunology, Gesellschaft für Biotechnologishe Forschung, German Research Centre for Biotechnology, Braunschweig, Germany; and Basel Institute for Immunology, Basel, Switzerland

Transgenic (Tg) L2 mice expressing high levels of the 2 (315) L chain contain only B cell populations involved in the first line of defense, i.e., B-1 and marginal zone (MZ) B cells. The strongly oligoclonal IgH chain repertoire of Tg B-1a cells in such mice was attributed to strong positive selection by autoantigens. In this study, we show that the MZ B cells of L2 mice correspond very closely to MZ B cells of normal mice, as revealed by surface marker expression and gene expression profiling. We demonstrate that the IgH chain repertoire of these Tg MZ B cells is extremely heterogeneous. This is in sharp contrast to the oligoclonality found in B-1a cells of the same mice, which was attributed to strong positive selection mediated by autoantigens. Therefore, the strong positive selection of the IgH chain repertoire in L2 mice is B-1a specific. Thus, our data demonstrate that despite common functional properties, MZ B and B-1a cells exhibit striking differences in their selection and/or maintenance requirements.

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