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The Journal of Immunology, 2003, 171: 6466-6477.
Copyright © 2003 by The American Association of Immunologists

Mouse Strain Differences in Plasmacytoid Dendritic Cell Frequency and Function Revealed by a Novel Monoclonal Antibody

Carine Asselin-Paturel1, Géraldine Brizard, Jean-Jacques Pin, Francine Brière and Giorgio Trinchieri

Laboratory for Immunological Research, Schering-Plough Research Institute, Dardilly, France

We report in this study the generation of a novel rat mAb that recognizes mouse plasmacytoid dendritic cells (pDC). This Ab, named 120G8, stains a small subset of CD11clow spleen cell with high specificity. This population produces high amounts of IFN-{alpha} upon in vitro viral stimulation. Both ex vivo- and in vitro-derived 120G8+ cells display a phenotype identical with that of the previously described mouse pDC (B220highLy6ChighGr1lowCD11b-CD11clow). Mice treated with 120G8 mAb are depleted of B220highLy6ChighCD11clow cells and have a much-reduced ability to produce IFN-{alpha} in response to in vivo CpG stimulation. The mAb 120G8 stains all and only B220highLy6ChighCD11clow pDC in all lymphoid organs. Immunohistochemical studies performed with this mAb indicate that pDC are located in the T cell area of spleen, lymph nodes, and Peyer’s patches. Although the Ag recognized by 120G8 is not yet known, we show that its expression is up-regulated by type I IFN on B cells and DC. Using this mAb in immunofluorescence studies demonstrates strain- and organ-specific differences in the frequency of pDC and other DC subsets. 129Sv mice have a much higher frequency of pDC, together with a lower frequency of conventional CD8{alpha}+CD11chigh DC, compared with C57BL/6 mice, both in spleen and blood. The higher ability of 129Sv mice to produce IFN-{alpha} in vivo is related to a higher number of pDC, but also to a higher ability of pDC from 129Sv mice to produce IFN-{alpha} in vitro in response to viral stimulation.




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Development of Murine Plasmacytoid Dendritic Cells Defined by Increased Expression of an Inhibitory NK Receptor, Ly49Q
J. Immunol., June 1, 2005; 174(11): 6657 - 6662.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
N. Toyama-Sorimachi, Y. Omatsu, A. Onoda, Y. Tsujimura, T. Iyoda, A. Kikuchi-Maki, H. Sorimachi, T. Dohi, S. Taki, K. Inaba, et al.
Inhibitory NK Receptor Ly49Q Is Expressed on Subsets of Dendritic Cells in a Cellular Maturation- and Cytokine Stimulation-Dependent Manner
J. Immunol., April 15, 2005; 174(8): 4621 - 4629.
[Abstract] [Full Text] [PDF]

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 JEMHome page
C. Asselin-Paturel, G. Brizard, K. Chemin, A. Boonstra, A. O'Garra, A. Vicari, and G. Trinchieri
Type I interferon dependence of plasmacytoid dendritic cell activation and migration
J. Exp. Med., April 4, 2005; 201(7): 1157 - 1167.
[Abstract] [Full Text] [PDF]

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 BloodHome page
Y. Kamogawa-Schifter, J. Ohkawa, S. Namiki, N. Arai, K.-i. Arai, and Y. Liu
Ly49Q defines 2 pDC subsets in mice
Blood, April 1, 2005; 105(7): 2787 - 2792.
[Abstract] [Full Text] [PDF]

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 Int ImmunolHome page
A. L. Mellor, P. Chandler, B. Baban, A. M. Hansen, B. Marshall, J. Pihkala, H. Waldmann, S. Cobbold, E. Adams, and D. H. Munn
Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
Int. Immunol., October 1, 2004; 16(10): 1391 - 1401.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
F. Fallarino, C. Asselin-Paturel, C. Vacca, R. Bianchi, S. Gizzi, M. C. Fioretti, G. Trinchieri, U. Grohmann, and P. Puccetti
Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement
J. Immunol., September 15, 2004; 173(6): 3748 - 3754.
[Abstract] [Full Text] [PDF]

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J. Diao, E. Winter, W. Chen, C. Cantin, and M. S. Cattral
Characterization of Distinct Conventional and Plasmacytoid Dendritic Cell-Committed Precursors in Murine Bone Marrow
J. Immunol., August 1, 2004; 173(3): 1826 - 1833.
[Abstract] [Full Text] [PDF]

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 JEMHome page
H. J. de Heer, H. Hammad, T. Soullie, D. Hijdra, N. Vos, M. A.M. Willart, H. C. Hoogsteden, and B. N. Lambrecht
Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen
J. Exp. Med., July 6, 2004; 200(1): 89 - 98.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
F.-X. Hubert, C. Voisine, C. Louvet, M. Heslan, and R. Josien
Rat Plasmacytoid Dendritic Cells Are an Abundant Subset of MHC Class II+ CD4+CD11b-OX62- and Type I IFN-Producing Cells That Exhibit Selective Expression of Toll-Like Receptors 7 and 9 and Strong Responsiveness to CpG
J. Immunol., June 15, 2004; 172(12): 7485 - 7494.
[Abstract] [Full Text] [PDF]

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 BloodHome page
A. Blasius, W. Vermi, A. Krug, F. Facchetti, M. Cella, and M. Colonna
A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha
Blood, June 1, 2004; 103(11): 4201 - 4206.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. M. Lund, L. Alexopoulou, A. Sato, M. Karow, N. C. Adams, N. W. Gale, A. Iwasaki, and R. A. Flavell
Recognition of single-stranded RNA viruses by Toll-like receptor 7
PNAS, April 13, 2004; 101(15): 5598 - 5603.
[Abstract] [Full Text] [PDF]


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