| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
The activation of dendritic cells (DC) leads to increased costimulatory activity (termed DC maturation) and, in some instances, production of immunomodulatory cytokines such as IL-12. Both innate and T cell-derived signals can promote DC activation but it is unclear to what extent the two classes of stimuli are interchangeable or regulate distinct aspects of DC function. In this study, we show that signals from newly activated CD4+ T cells cannot initiate IL-12 synthesis although they can amplify secretion of bioactive IL-12 p70 by DC exposed to an appropriate innate stimulus. This occurs exclusively in cis and does not influence IL-12 synthesis by bystander DC that do not present Ag. In marked contrast, signals from newly activated CD4+ T cells can induce an increase in DC costimulatory activity in the absence of any innate priming. This occurs both in cis and in trans, affecting all DC in the microenvironment, including those that do not bear specific Ag. Consistent with the latter, we show that newly activated CD4+ T cells in vivo can deliver "help" in trans, effectively lowering the number of MHC/peptide complexes required for proliferation of third-party naive CD4+ T cells recognizing Ag on bystander DC. These results demonstrate that DC maturation and cytokine production are regulated distinctly by innate stimuli vs signals from CD4+ T cells and reveal a process of trans activation of DC without secretion of polarizing cytokines that takes place during T cell priming and may be involved in amplifying immune responses.
This article has been cited by other articles:
|
|
 |
|
  N. Zietara, M. Lyszkiewicz, N. Gekara, J. Puchalka, V. A. P. M. Dos Santos, C. R. Hunt, T. K. Pandita, S. Lienenklaus, and S. Weiss Absence of IFN-{beta} Impairs Antigen Presentation Capacity of Splenic Dendritic Cells via Down-Regulation of Heat Shock Protein 70 J. Immunol., July 15, 2009; 183(2): 1099 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Bucks, J. A. Norton, A. C. Boesteanu, Y. M. Mueller, and P. D. Katsikis Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion J. Immunol., June 1, 2009; 182(11): 6697 - 6708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. LeibundGut-Landmann, F. Osorio, G. D. Brown, and C. Reis e Sousa Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses Blood, December 15, 2008; 112(13): 4971 - 4980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nobile, M. Lind, F. Miro, K. Chemin, M. Tourret, G. Occhipinti, S. Dogniaux, S. Amigorena, and C. Hivroz Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes Blood, April 1, 2008; 111(7): 3579 - 3590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cools, P. Ponsaerts, V. F. I. Van Tendeloo, and Z. N. Berneman Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells J. Leukoc. Biol., December 1, 2007; 82(6): 1365 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. F. Hermans, J. D. Silk, U. Gileadi, S. H. Masri, D. Shepherd, K. J. Farrand, M. Salio, and V. Cerundolo Dendritic Cell Function Can Be Modulated through Cooperative Actions of TLR Ligands and Invariant NKT Cells J. Immunol., March 1, 2007; 178(5): 2721 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yadav, D. J. Zammit, L. Lefrancois, and A. T. Vella Effects of LPS-mediated bystander activation in the innate immune system J. Leukoc. Biol., December 1, 2006; 80(6): 1251 - 1261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Miro, C. Nobile, N. Blanchard, M. Lind, O. Filipe-Santos, C. Fieschi, A. Chapgier, G. Vogt, L. de Beaucoudrey, D. S. Kumararatne, et al. T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN-{gamma} Signaling in T Cells J. Immunol., September 15, 2006; 177(6): 3625 - 3634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Devilder, S. Maillet, I. Bouyge-Moreau, E. Donnadieu, M. Bonneville, and E. Scotet Potentiation of Antigen-Stimulated V{gamma}9V{delta}2 T Cell Cytokine Production by Immature Dendritic Cells (DC) and Reciprocal Effect on DC Maturation J. Immunol., February 1, 2006; 176(3): 1386 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mallone, S. A. Kochik, H. Reijonen, B. Carson, S. F. Ziegler, W. W. Kwok, and G. T. Nepom Functional avidity directs T-cell fate in autoreactive CD4+ T cells Blood, October 15, 2005; 106(8): 2798 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Segura, C. Nicco, B. Lombard, P. Veron, G. Raposo, F. Batteux, S. Amigorena, and C. Thery ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming Blood, July 1, 2005; 106(1): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Fujii, K. Liu, C. Smith, A. J. Bonito, and R. M. Steinman The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation J. Exp. Med., June 21, 2004; 199(12): 1607 - 1618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Misra, J. Bayry, S. Lacroix-Desmazes, M. D. Kazatchkine, and S. V. Kaveri Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells J. Immunol., April 15, 2004; 172(8): 4676 - 4680. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
